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RNA (C5-cytosine) Methyltransferases.
Biochemistry (Mosc) 2019; 84(8):851-869B

Abstract

The review summarizes the data on pro- and eukaryotic RNA (C5-cytosine) methyltransferases. The structure, intracellular location, RNA targets, and catalytic mechanisms of these enzymes, as well as the functional role of methylated cytosine residues in RNA are presented. The functions of RNA (C5-cytosine) methyltransferases unassociated with their methylation activity are discussed. Special attention is given to the similarities and differences in the structures and mechanisms of action of RNA and DNA methyltransferases. The data on the association of mutations in the RNA (C5-cytosine) methyltransferases genes and human diseases are presented.

Authors+Show Affiliations

Lomonosov Moscow State University, Institute of Functional Genomics, Moscow, 119234, Russia. svetlana@belozersky.msu.ru.Lomonosov Moscow State University, Faculty of Chemistry, Moscow, 119991, Russia.Lomonosov Moscow State University, Faculty of Chemistry, Moscow, 119991, Russia. Skolkovo Institute of Science and Technology, Skolkovo, 121205, Moscow Region, Russia. Institute of Bioorganic Chemistry, Moscow, 117997, Russia.Lomonosov Moscow State University, Institute of Functional Genomics, Moscow, 119234, Russia. Lomonosov Moscow State University, Faculty of Chemistry, Moscow, 119991, Russia. Skolkovo Institute of Science and Technology, Skolkovo, 121205, Moscow Region, Russia. Petrov National Medical Research Center of Oncology, St. Petersburg, 197758, Russia.Lomonosov Moscow State University, Faculty of Chemistry, Moscow, 119991, Russia. Skolkovo Institute of Science and Technology, Skolkovo, 121205, Moscow Region, Russia. Institute of Bioorganic Chemistry, Moscow, 117997, Russia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31522668

Citation

Kuznetsova, S A., et al. "RNA (C5-cytosine) Methyltransferases." Biochemistry. Biokhimiia, vol. 84, no. 8, 2019, pp. 851-869.
Kuznetsova SA, Petrukov KS, Pletnev FI, et al. RNA (C5-cytosine) Methyltransferases. Biochemistry Mosc. 2019;84(8):851-869.
Kuznetsova, S. A., Petrukov, K. S., Pletnev, F. I., Sergiev, P. V., & Dontsova, O. A. (2019). RNA (C5-cytosine) Methyltransferases. Biochemistry. Biokhimiia, 84(8), pp. 851-869. doi:10.1134/S0006297919080029.
Kuznetsova SA, et al. RNA (C5-cytosine) Methyltransferases. Biochemistry Mosc. 2019;84(8):851-869. PubMed PMID: 31522668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - RNA (C5-cytosine) Methyltransferases. AU - Kuznetsova,S A, AU - Petrukov,K S, AU - Pletnev,F I, AU - Sergiev,P V, AU - Dontsova,O A, PY - 2019/9/17/entrez SP - 851 EP - 869 JF - Biochemistry. Biokhimiia JO - Biochemistry Mosc. VL - 84 IS - 8 N2 - The review summarizes the data on pro- and eukaryotic RNA (C5-cytosine) methyltransferases. The structure, intracellular location, RNA targets, and catalytic mechanisms of these enzymes, as well as the functional role of methylated cytosine residues in RNA are presented. The functions of RNA (C5-cytosine) methyltransferases unassociated with their methylation activity are discussed. Special attention is given to the similarities and differences in the structures and mechanisms of action of RNA and DNA methyltransferases. The data on the association of mutations in the RNA (C5-cytosine) methyltransferases genes and human diseases are presented. SN - 1608-3040 UR - https://www.unboundmedicine.com/medline/citation/31522668/RNA_(C5-cytosine)_Methyltransferases L2 - https://dx.doi.org/10.1134/S0006297919080029 DB - PRIME DP - Unbound Medicine ER -