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Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 1.

Abstract

Multiple Sclerosis (MS) is chronic, inflammatory, a neurologic disorder of the central nervous system (CNS). Although the exact mechanisms of MS have not been yet discovered some drugs are found helpful for its treatment. These drugs which are divided into the first line, second line and third-line therapies, have demonstrated to be helpful for MS patients based on immune basic of the disease. Previous studies have been indicated that deterioration of MS condition is associated with a stronger immune system. Most of these therapies impact on the immune system and immune cells including shifting immune cell populations toward a Th2 dominant population or suppression of the immune system so that auto-reactive immune cells cannot attack myelin sheath of neurons. Beside many beneficial effects of these drugs, some adverse effects (AE) have been reported in many experiments and clinical trials among patients suffering from MS. In this review, we conclude some AEs of beta interferon, mitoxantrone, natalizumab and fingolimod, reported in different papers and we continue the rest of the drugs in second part of our review article.

Authors+Show Affiliations

School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.Department of Pharmacy, Rajiv Gandhi University of Health Sciences Bengaluru, India.Department of Neurology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.Department of Midwifery, School of Nursing and Midwifery, Islamic Azad University Shahrekord Branch Shahrekord, Iran.School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31523357

Citation

Rafiee Zadeh, Aryan, et al. "Mechanism and Adverse Effects of Multiple Sclerosis Drugs: a Review Article. Part 1." International Journal of Physiology, Pathophysiology and Pharmacology, vol. 11, no. 4, 2019, pp. 95-104.
Rafiee Zadeh A, Askari M, Azadani NN, et al. Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 1. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):95-104.
Rafiee Zadeh, A., Askari, M., Azadani, N. N., Ataei, A., Ghadimi, K., Tavoosi, N., & Falahatian, M. (2019). Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 1. International Journal of Physiology, Pathophysiology and Pharmacology, 11(4), pp. 95-104.
Rafiee Zadeh A, et al. Mechanism and Adverse Effects of Multiple Sclerosis Drugs: a Review Article. Part 1. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):95-104. PubMed PMID: 31523357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism and adverse effects of multiple sclerosis drugs: a review article. Part 1. AU - Rafiee Zadeh,Aryan, AU - Askari,Mozhde, AU - Azadani,Niloufar Nasr, AU - Ataei,Akram, AU - Ghadimi,Keyvan, AU - Tavoosi,Nooshin, AU - Falahatian,Masih, Y1 - 2019/08/15/ PY - 2019/06/09/received PY - 2019/06/17/accepted PY - 2019/9/17/entrez PY - 2019/9/17/pubmed PY - 2019/9/17/medline KW - Mechanism KW - adverse effect KW - drug KW - multiple sclerosis SP - 95 EP - 104 JF - International journal of physiology, pathophysiology and pharmacology JO - Int J Physiol Pathophysiol Pharmacol VL - 11 IS - 4 N2 - Multiple Sclerosis (MS) is chronic, inflammatory, a neurologic disorder of the central nervous system (CNS). Although the exact mechanisms of MS have not been yet discovered some drugs are found helpful for its treatment. These drugs which are divided into the first line, second line and third-line therapies, have demonstrated to be helpful for MS patients based on immune basic of the disease. Previous studies have been indicated that deterioration of MS condition is associated with a stronger immune system. Most of these therapies impact on the immune system and immune cells including shifting immune cell populations toward a Th2 dominant population or suppression of the immune system so that auto-reactive immune cells cannot attack myelin sheath of neurons. Beside many beneficial effects of these drugs, some adverse effects (AE) have been reported in many experiments and clinical trials among patients suffering from MS. In this review, we conclude some AEs of beta interferon, mitoxantrone, natalizumab and fingolimod, reported in different papers and we continue the rest of the drugs in second part of our review article. SN - 1944-8171 UR - https://www.unboundmedicine.com/medline/citation/31523357/Mechanism_and_adverse_effects_of_multiple_sclerosis_drugs:_a_review_article._Part_1 L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31523357/ DB - PRIME DP - Unbound Medicine ER -