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Latest Developments in Post-Mortem Fetal Imaging.

Abstract

A sustained decline in parental consent rates for perinatal autopsies has driven the development of less-invasive methods for death investigation. A wide variety of imaging modalities have been developed for this purpose and include post-mortem whole body MRI, ultrasound, CT and micro-focus CT techniques. These are also vital for 'minimally invasive' methods which include potential for tissue sampling, such as image guidance for targeted biopsies and laparoscopic assisted techniques. In this article we address the range of imaging techniques currently in clinical practice, and those under development. Significant advances in high field MRI and micro-focus CT imaging show particular promise for smaller and earlier gestation fetuses. We also review how MRI biomarkers such as diffusion weighted imaging and organ volumetric analysis may aid diagnosis and image interpretation in the absence of autopsy data. 3D printing and augmented reality may help make imaging findings more accessible to parents, colleagues and trainees.

Authors+Show Affiliations

Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. UCL Great Ormond Street Institute of Child Health, London, UK. NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. UCL Great Ormond Street Institute of Child Health, London, UK. NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. UCL Great Ormond Street Institute of Child Health, London, UK. NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. UCL Great Ormond Street Institute of Child Health, London, UK. NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31525275

Citation

Shelmerdine, Susan C., et al. "Latest Developments in Post-Mortem Fetal Imaging." Prenatal Diagnosis, 2019.
Shelmerdine SC, Hutchinson JC, Arthurs OJ, et al. Latest Developments in Post-Mortem Fetal Imaging. Prenat Diagn. 2019.
Shelmerdine, S. C., Hutchinson, J. C., Arthurs, O. J., & Sebire, N. J. (2019). Latest Developments in Post-Mortem Fetal Imaging. Prenatal Diagnosis, doi:10.1002/pd.5562.
Shelmerdine SC, et al. Latest Developments in Post-Mortem Fetal Imaging. Prenat Diagn. 2019 Sep 16; PubMed PMID: 31525275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Latest Developments in Post-Mortem Fetal Imaging. AU - Shelmerdine,Susan C, AU - Hutchinson,John Ciaran, AU - Arthurs,Owen J, AU - Sebire,Neil J, Y1 - 2019/09/16/ PY - 2019/07/18/received PY - 2019/08/29/revised PY - 2019/09/07/accepted PY - 2019/9/17/entrez PY - 2019/9/17/pubmed PY - 2019/9/17/medline JF - Prenatal diagnosis JO - Prenat. Diagn. N2 - A sustained decline in parental consent rates for perinatal autopsies has driven the development of less-invasive methods for death investigation. A wide variety of imaging modalities have been developed for this purpose and include post-mortem whole body MRI, ultrasound, CT and micro-focus CT techniques. These are also vital for 'minimally invasive' methods which include potential for tissue sampling, such as image guidance for targeted biopsies and laparoscopic assisted techniques. In this article we address the range of imaging techniques currently in clinical practice, and those under development. Significant advances in high field MRI and micro-focus CT imaging show particular promise for smaller and earlier gestation fetuses. We also review how MRI biomarkers such as diffusion weighted imaging and organ volumetric analysis may aid diagnosis and image interpretation in the absence of autopsy data. 3D printing and augmented reality may help make imaging findings more accessible to parents, colleagues and trainees. SN - 1097-0223 UR - https://www.unboundmedicine.com/medline/citation/31525275/Latest_Developments_in_Post-Mortem_Fetal_Imaging L2 - https://doi.org/10.1002/pd.5562 DB - PRIME DP - Unbound Medicine ER -