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Ambient air pollution exposure and gestational diabetes mellitus in Guangzhou, China: A prospective cohort study.
Sci Total Environ. 2020 Jan 10; 699:134390.ST

Abstract

BACKGROUND

Evidence concerning the effect of ambient air pollution exposure on gestational diabetes mellitus (GDM) is limited. No published studies have examined maternal weekly air pollution exposure and GDM, and the possible effect modification by folic acid supplementation has not been assessed.

OBJECTIVES

To evaluate the association between air pollution exposure and GDM at trimester and weekly levels, and to explore the potential effect modification by folic acid supplementation.

METHODS

A total of 5421 pregnant women were recruited during 2011-2014 in Guangzhou, China. Daily PM2.5, PM10, SO2 and NO2 levels were collected from 10 monitoring stations. Individual's exposure during pregnancy was estimated using inverse-distance weighting approach. Binary logistic regression was used to examine the trimester-specific association between air pollution exposure and GDM. Distributed lag models (DLMs) were applied to estimate maternal weekly air pollution exposure and GDM. Stratified analyses by folic acid supplementation and interaction test were performed.

RESULTS

The GDM incidence was 11.69%. An interquartile range (IQR) increase in first trimester SO2 was associated with increased GDM risk in the single pollutant model, the adjusted odds ratio (aOR) and 95% confidence interval (CI) was 1.22 (1.02-1.47). In DLMs, an IQR increase in SO2 during 4th to 10th gestational weeks was associated with increased GDM risk, with the strongest effect in the 7th gestational week. When stratified by maternal folic acid supplementation, first trimester exposure to SO2 was associated with increased GDM risk among women taking folic acid supplements (aOR = 1.25, 95% CI: 1.03-1.53) and P value for interaction was 0.13. No significant effects were observed for PM2.5, PM10 and NO2.

CONCLUSION

First trimester exposure to SO2 was associated with increased GDM risk, especially during the 4th to 10th gestational weeks. The effect might be stronger among women taking folic acid supplements.

Authors+Show Affiliations

School of Public Health, Sun Yat-sen University, Guangzhou, China; Shanghai Typhoon Institute, China Meteorological Administration, Shanghai 200030, China; Laboratory of Meteorology and Health, Shanghai Meteorological Service, Shanghai 200030, China.School of Public Health, Sun Yat-sen University, Guangzhou, China.School of Public Health, Sun Yat-sen University, Guangzhou, China.Department of Ultrasound, Panyu Maternal and Child Care Service Center of Guangzhou.Center for Reproductive Medicine, The first Affiliated Hospital of Sun Yat-sen University, China.Department of Emergency, Guangzhou Women and Children's Medical Center, Guangzhou.Department of Pediatrics in Traditional Chinese Medicine, Guangzhou Women and Children's Medical Center.Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.Department of Obstetrics, Panyu Maternal and Child Care Service Center of Guangzhou, China.Department of Obstetrics, Panyu Maternal and Child Care Service Center of Guangzhou, China.School of Public Health, The University of Queensland, Herston, Australia.School of Public Health and Community Medicine, University of New South Wales, Sydney, New South Wales, Australia.School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: wangqiong@mail.sysu.edu.cn.School of Public Health, Sun Yat-sen University, Guangzhou, China; Shanghai Typhoon Institute, China Meteorological Administration, Shanghai 200030, China; Laboratory of Meteorology and Health, Shanghai Meteorological Service, Shanghai 200030, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31525546

Citation

Zhang, Huanhuan, et al. "Ambient Air Pollution Exposure and Gestational Diabetes Mellitus in Guangzhou, China: a Prospective Cohort Study." The Science of the Total Environment, vol. 699, 2020, p. 134390.
Zhang H, Dong H, Ren M, et al. Ambient air pollution exposure and gestational diabetes mellitus in Guangzhou, China: A prospective cohort study. Sci Total Environ. 2020;699:134390.
Zhang, H., Dong, H., Ren, M., Liang, Q., Shen, X., Wang, Q., Yu, L., Lin, H., Luo, Q., Chen, W., Knibbs, L. D., Jalaludin, B., Wang, Q., & Huang, C. (2020). Ambient air pollution exposure and gestational diabetes mellitus in Guangzhou, China: A prospective cohort study. The Science of the Total Environment, 699, 134390. https://doi.org/10.1016/j.scitotenv.2019.134390
Zhang H, et al. Ambient Air Pollution Exposure and Gestational Diabetes Mellitus in Guangzhou, China: a Prospective Cohort Study. Sci Total Environ. 2020 Jan 10;699:134390. PubMed PMID: 31525546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ambient air pollution exposure and gestational diabetes mellitus in Guangzhou, China: A prospective cohort study. AU - Zhang,Huanhuan, AU - Dong,Haotian, AU - Ren,Meng, AU - Liang,Qianhong, AU - Shen,Xiaoting, AU - Wang,Qiang, AU - Yu,Le, AU - Lin,Hualiang, AU - Luo,Qiwei, AU - Chen,Weiyi, AU - Knibbs,Luke D, AU - Jalaludin,Bin, AU - Wang,Qiong, AU - Huang,Cunrui, Y1 - 2019/09/10/ PY - 2019/05/30/received PY - 2019/09/08/revised PY - 2019/09/09/accepted PY - 2019/9/17/pubmed PY - 2019/12/21/medline PY - 2019/9/17/entrez KW - Air pollution KW - Folic acid supplementation KW - Gestational diabetes mellitus KW - Pregnancy SP - 134390 EP - 134390 JF - The Science of the total environment JO - Sci. Total Environ. VL - 699 N2 - BACKGROUND: Evidence concerning the effect of ambient air pollution exposure on gestational diabetes mellitus (GDM) is limited. No published studies have examined maternal weekly air pollution exposure and GDM, and the possible effect modification by folic acid supplementation has not been assessed. OBJECTIVES: To evaluate the association between air pollution exposure and GDM at trimester and weekly levels, and to explore the potential effect modification by folic acid supplementation. METHODS: A total of 5421 pregnant women were recruited during 2011-2014 in Guangzhou, China. Daily PM2.5, PM10, SO2 and NO2 levels were collected from 10 monitoring stations. Individual's exposure during pregnancy was estimated using inverse-distance weighting approach. Binary logistic regression was used to examine the trimester-specific association between air pollution exposure and GDM. Distributed lag models (DLMs) were applied to estimate maternal weekly air pollution exposure and GDM. Stratified analyses by folic acid supplementation and interaction test were performed. RESULTS: The GDM incidence was 11.69%. An interquartile range (IQR) increase in first trimester SO2 was associated with increased GDM risk in the single pollutant model, the adjusted odds ratio (aOR) and 95% confidence interval (CI) was 1.22 (1.02-1.47). In DLMs, an IQR increase in SO2 during 4th to 10th gestational weeks was associated with increased GDM risk, with the strongest effect in the 7th gestational week. When stratified by maternal folic acid supplementation, first trimester exposure to SO2 was associated with increased GDM risk among women taking folic acid supplements (aOR = 1.25, 95% CI: 1.03-1.53) and P value for interaction was 0.13. No significant effects were observed for PM2.5, PM10 and NO2. CONCLUSION: First trimester exposure to SO2 was associated with increased GDM risk, especially during the 4th to 10th gestational weeks. The effect might be stronger among women taking folic acid supplements. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/31525546/Ambient_air_pollution_exposure_and_gestational_diabetes_mellitus_in_Guangzhou_China:_A_prospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(19)34381-5 DB - PRIME DP - Unbound Medicine ER -