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Association between coffee consumption and risk of bladder cancer in a meta-analysis of 16 prospective studies.
Nutr Metab (Lond). 2019; 16:66.NM

Abstract

BACKGROUND

Current evidence remains equivocal as to whether and how consumption of coffee may be associated with risk of bladder cancer, and potential influence of confounding by smoking on this association is yet to be elucidated. We conducted an updated meta-analysis of prospective studies to address these issues.

METHODS

Relevant studies were identified by searching PubMed and EMBASE databases from inception to April 2019. A random-effects model was used to estimate summary relative risk (RR) with corresponding 95% confidence interval (CI) of bladder cancer associated with coffee consumption.

RESULTS

The final analysis included 16 prospective studies comprising 2,122,816 participants and 11,848 bladder cancer cases. Overall, coffee consumption was not associated with risk of bladder cancer (RR high-vs-low = 1.07, 95% CI: 0.96-1.20). The lack of association persisted in the strata defined by sex or participants' smoking status. Meta-regression analyses identified the number cases (P difference = 0.06) and the degree of adjustment for smoking (P difference = 0.04) as potential sources of heterogeneity. There was an increased risk of bladder cancer related to higher coffee consumption among studies with fewer cases (RR high-vs-low = 1.38, 95% CI: 1.05-1.81) and among those with poorer adjustment for smoking (RR high-vs-low = 1.48, 95% CI: 1.14-1.93). Results were similar in the dose-response analyses (RR 1 cup/d = 1.01, 95% CI: 0.98-1.03).

CONCLUSION

Best evidence available to date does not support an independent association between coffee consumption and bladder cancer risk. Some direct associations observed in individual studies may be a result of residual confounding by smoking.

SUPPLEMENTARY INFORMATION

Supplementary information accompanies this paper at 10.1186/s12986-019-0390-3.

Authors+Show Affiliations

Department of Nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, 315010 China.Department of Nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, 315010 China.2Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, 510000 China.2Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, 510000 China.3Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31528185

Citation

Dai, Zhi-Wei, et al. "Association Between Coffee Consumption and Risk of Bladder Cancer in a Meta-analysis of 16 Prospective Studies." Nutrition & Metabolism, vol. 16, 2019, p. 66.
Dai ZW, Cai KD, Li FR, et al. Association between coffee consumption and risk of bladder cancer in a meta-analysis of 16 prospective studies. Nutr Metab (Lond). 2019;16:66.
Dai, Z. W., Cai, K. D., Li, F. R., Wu, X. B., & Chen, G. C. (2019). Association between coffee consumption and risk of bladder cancer in a meta-analysis of 16 prospective studies. Nutrition & Metabolism, 16, 66. https://doi.org/10.1186/s12986-019-0390-3
Dai ZW, et al. Association Between Coffee Consumption and Risk of Bladder Cancer in a Meta-analysis of 16 Prospective Studies. Nutr Metab (Lond). 2019;16:66. PubMed PMID: 31528185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between coffee consumption and risk of bladder cancer in a meta-analysis of 16 prospective studies. AU - Dai,Zhi-Wei, AU - Cai,Ke-Dan, AU - Li,Fu-Rong, AU - Wu,Xian-Bo, AU - Chen,Guo-Chong, Y1 - 2019/09/13/ PY - 2019/06/16/received PY - 2019/09/06/accepted PY - 2019/9/19/entrez PY - 2019/9/19/pubmed PY - 2019/9/19/medline KW - Bladder cancer KW - Coffee KW - Cohort studies KW - Meta-analysis SP - 66 EP - 66 JF - Nutrition & metabolism JO - Nutr Metab (Lond) VL - 16 N2 - BACKGROUND: Current evidence remains equivocal as to whether and how consumption of coffee may be associated with risk of bladder cancer, and potential influence of confounding by smoking on this association is yet to be elucidated. We conducted an updated meta-analysis of prospective studies to address these issues. METHODS: Relevant studies were identified by searching PubMed and EMBASE databases from inception to April 2019. A random-effects model was used to estimate summary relative risk (RR) with corresponding 95% confidence interval (CI) of bladder cancer associated with coffee consumption. RESULTS: The final analysis included 16 prospective studies comprising 2,122,816 participants and 11,848 bladder cancer cases. Overall, coffee consumption was not associated with risk of bladder cancer (RR high-vs-low = 1.07, 95% CI: 0.96-1.20). The lack of association persisted in the strata defined by sex or participants' smoking status. Meta-regression analyses identified the number cases (P difference = 0.06) and the degree of adjustment for smoking (P difference = 0.04) as potential sources of heterogeneity. There was an increased risk of bladder cancer related to higher coffee consumption among studies with fewer cases (RR high-vs-low = 1.38, 95% CI: 1.05-1.81) and among those with poorer adjustment for smoking (RR high-vs-low = 1.48, 95% CI: 1.14-1.93). Results were similar in the dose-response analyses (RR 1 cup/d = 1.01, 95% CI: 0.98-1.03). CONCLUSION: Best evidence available to date does not support an independent association between coffee consumption and bladder cancer risk. Some direct associations observed in individual studies may be a result of residual confounding by smoking. SUPPLEMENTARY INFORMATION: Supplementary information accompanies this paper at 10.1186/s12986-019-0390-3. SN - 1743-7075 UR - https://www.unboundmedicine.com/medline/citation/31528185/Association_between_coffee_consumption_and_risk_of_bladder_cancer_in_a_meta_analysis_of_16_prospective_studies_ DB - PRIME DP - Unbound Medicine ER -
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