Tags

Type your tag names separated by a space and hit enter

Solitary rectal ulcer syndrome: addition of rectal therapies to biofeedback is more effective than biofeedback alone.
Gastroenterol Hepatol Bed Bench 2019; 12(3):197-202GH

Abstract

Aim

We designed this study to evaluate the effectiveness of the combination of topical rectal therapy with biofeedback in treatment of solitary rectal ulcer compared to single biofeedback therapy.

Background

Biofeedback therapy is an appropriate treatment for patients with solitary rectal ulcer syndrome (SRUS) but it seems that it is not effective alone. Topical medical therapies are supposed to have an additive role to biofeedback.

Methods

This randomized, controlled trial was conducted on 63 patients with SRUS. Patients were randomly enrolled into two groups of combination and single therapy. The patients in combination group (n=31) received biofeedback plus a topical therapy (an enema contained dexamethasone, sulfasalazine and bismuth) and the patients in single therapy group (n=32) were treated with biofeedback alone.

Results

Endoscopic responses to treatment in the combination and single groups were 80% and 50%, respectively (P<0.05). Clinical improvement in symptoms such as difficulty to evacuate, digitation to evacuate, feeling of incomplete evacuation, time to need to evacuation and life style alternation were significantly better in treated group by combination therapy than single therapy. Regarding to the mean total score based on all subjective parameters, the results were also significantly better in the treated group by combination therapy.

Conclusion

Topical anti-inflammatory therapies in combination with biofeedback is an efficient treatment for patients with SRUS.

Authors+Show Affiliations

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Departments of Sociocultural, Tehran University of Medical Sciences, Tehran, Iran.Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31528302

Citation

Abdi, Saeed, et al. "Solitary Rectal Ulcer Syndrome: Addition of Rectal Therapies to Biofeedback Is More Effective Than Biofeedback Alone." Gastroenterology and Hepatology From Bed to Bench, vol. 12, no. 3, 2019, pp. 197-202.
Abdi S, Tavakolikia N, Yamini M, et al. Solitary rectal ulcer syndrome: addition of rectal therapies to biofeedback is more effective than biofeedback alone. Gastroenterol Hepatol Bed Bench. 2019;12(3):197-202.
Abdi, S., Tavakolikia, N., Yamini, M., Bagheri, M., Sadeghi, A., Pourhoseingholi, M. A., ... Aghajanpoor Pasha, M. (2019). Solitary rectal ulcer syndrome: addition of rectal therapies to biofeedback is more effective than biofeedback alone. Gastroenterology and Hepatology From Bed to Bench, 12(3), pp. 197-202.
Abdi S, et al. Solitary Rectal Ulcer Syndrome: Addition of Rectal Therapies to Biofeedback Is More Effective Than Biofeedback Alone. Gastroenterol Hepatol Bed Bench. 2019;12(3):197-202. PubMed PMID: 31528302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solitary rectal ulcer syndrome: addition of rectal therapies to biofeedback is more effective than biofeedback alone. AU - Abdi,Saeed, AU - Tavakolikia,Narjes, AU - Yamini,Mehdi, AU - Bagheri,Mohammad, AU - Sadeghi,Amir, AU - Pourhoseingholi,Mohamad Amin, AU - Shahrokh,Shabnam, AU - Aghajanpoor Pasha,Morteza, PY - 2019/9/19/entrez PY - 2019/9/19/pubmed PY - 2019/9/19/medline KW - Biofeedback KW - Endoscopic responses KW - SRUS SP - 197 EP - 202 JF - Gastroenterology and hepatology from bed to bench JO - Gastroenterol Hepatol Bed Bench VL - 12 IS - 3 N2 - Aim: We designed this study to evaluate the effectiveness of the combination of topical rectal therapy with biofeedback in treatment of solitary rectal ulcer compared to single biofeedback therapy. Background: Biofeedback therapy is an appropriate treatment for patients with solitary rectal ulcer syndrome (SRUS) but it seems that it is not effective alone. Topical medical therapies are supposed to have an additive role to biofeedback. Methods: This randomized, controlled trial was conducted on 63 patients with SRUS. Patients were randomly enrolled into two groups of combination and single therapy. The patients in combination group (n=31) received biofeedback plus a topical therapy (an enema contained dexamethasone, sulfasalazine and bismuth) and the patients in single therapy group (n=32) were treated with biofeedback alone. Results: Endoscopic responses to treatment in the combination and single groups were 80% and 50%, respectively (P<0.05). Clinical improvement in symptoms such as difficulty to evacuate, digitation to evacuate, feeling of incomplete evacuation, time to need to evacuation and life style alternation were significantly better in treated group by combination therapy than single therapy. Regarding to the mean total score based on all subjective parameters, the results were also significantly better in the treated group by combination therapy. Conclusion: Topical anti-inflammatory therapies in combination with biofeedback is an efficient treatment for patients with SRUS. SN - 2008-2258 UR - https://www.unboundmedicine.com/medline/citation/31528302/Solitary_rectal_ulcer_syndrome:_addition_of_rectal_therapies_to_biofeedback_is_more_effective_than_biofeedback_alone L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31528302/ DB - PRIME DP - Unbound Medicine ER -