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Radiographic changes in TMJ in relation to serology and disease activity in RA patients.
Dentomaxillofac Radiol 2020; 49(1):20190186DR

Abstract

OBJECTIVES

This study was undertaken as an attempt to assess radiographic temporomandibular joint (TMJ) changes in relation to rheumatoid factor (RF), anticitrullinated protein (ACCP) antibodies and disease activity score 28 (DAS28) in rheumatoid arthritis (RA) patients to find the best predictor of rheumatoid affection of the TMJ with the ultimate goal of maintaining TMJ function and preventing joint damage.

METHODS

20 Rheumatoid Arthritis patients as well as 20 volunteers were included in this study. RA group were assessed for RF, ACCP, DAS28. Both groups were assessed by CBCT for TMJ dimensions and radiographic osteoarthritic changes. All data were statistically analyzed.

RESULTS

Rheumatoid Arthritis group showed significantly less condylar height and more radiographic osteoarthritic changes than the control group. RF showed no significant correlation with either TMJ measurements or TMJ radiographic osteoarthritic changes. ACCP showed significant inverse correlation with condylar height and anteroposterior (AP) dimensions, but non-significant relation with mediolateral dimension and radiographic osteoarthritic changes. DAS28 showed significant inverse correlation with condylar AP and mediolateral dimensions. It also showed significant correlation with flattening of the TMJ condylar head and flattening of the articular fossa. Patients with high and moderate disease activity showed significantly smaller AP TMJ dimension than patients with low disease activity. Disease activity showed statistically significant direct correlation with all osteoarthritic changes except for erosions of the glenoid fossa and condyle.

CONCLUSION

Disease Activity Score28 score and disease activity are strong indicators of TMJ affection in RA patients when compared to RF and ACCP. ACCP is a better indicator of changes in condylar measurements than TMJ osteoarthritic changes. While RF is the least efficient indicator of TMJ involvement in RA patients.

Authors+Show Affiliations

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Assuit University, Assuit, Egypt.Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Cairo University, Cairo, Egypt.Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Ain-Shams University, Cairo, Egypt.Department of Rheumatology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31530023

Citation

Youssef Mohamed, Mostafa Mahmoud, et al. "Radiographic Changes in TMJ in Relation to Serology and Disease Activity in RA Patients." Dento Maxillo Facial Radiology, vol. 49, no. 1, 2020, p. 20190186.
Youssef Mohamed MM, Dahaba MM, Farid MM, et al. Radiographic changes in TMJ in relation to serology and disease activity in RA patients. Dentomaxillofac Radiol. 2020;49(1):20190186.
Youssef Mohamed, M. M., Dahaba, M. M., Farid, M. M., & Ali Elsayed, A. M. (2020). Radiographic changes in TMJ in relation to serology and disease activity in RA patients. Dento Maxillo Facial Radiology, 49(1), p. 20190186. doi:10.1259/dmfr.20190186.
Youssef Mohamed MM, et al. Radiographic Changes in TMJ in Relation to Serology and Disease Activity in RA Patients. Dentomaxillofac Radiol. 2020;49(1):20190186. PubMed PMID: 31530023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiographic changes in TMJ in relation to serology and disease activity in RA patients. AU - Youssef Mohamed,Mostafa Mahmoud, AU - Dahaba,Mushira M, AU - Farid,Mary Medhat, AU - Ali Elsayed,Adel Mahmoud, Y1 - 2019/09/20/ PY - 2021/01/01/pmc-release PY - 2019/9/19/pubmed PY - 2019/12/31/medline PY - 2019/9/19/entrez KW - Anti CitrullinatedProtein Antibodies KW - Arthritis KW - Cone-Beam Computed Tomography KW - Disability Evaluation KW - Disease Activity Score KW - Disease Progression KW - Predictive Value of Tests KW - Rheumatoid Arthritis KW - Rheumatoid Factor KW - Rheumatoid/diagnosis KW - Rheumatology/methods KW - Temporomandibular Joint SP - 20190186 EP - 20190186 JF - Dento maxillo facial radiology JO - Dentomaxillofac Radiol VL - 49 IS - 1 N2 - OBJECTIVES: This study was undertaken as an attempt to assess radiographic temporomandibular joint (TMJ) changes in relation to rheumatoid factor (RF), anticitrullinated protein (ACCP) antibodies and disease activity score 28 (DAS28) in rheumatoid arthritis (RA) patients to find the best predictor of rheumatoid affection of the TMJ with the ultimate goal of maintaining TMJ function and preventing joint damage. METHODS: 20 Rheumatoid Arthritis patients as well as 20 volunteers were included in this study. RA group were assessed for RF, ACCP, DAS28. Both groups were assessed by CBCT for TMJ dimensions and radiographic osteoarthritic changes. All data were statistically analyzed. RESULTS: Rheumatoid Arthritis group showed significantly less condylar height and more radiographic osteoarthritic changes than the control group. RF showed no significant correlation with either TMJ measurements or TMJ radiographic osteoarthritic changes. ACCP showed significant inverse correlation with condylar height and anteroposterior (AP) dimensions, but non-significant relation with mediolateral dimension and radiographic osteoarthritic changes. DAS28 showed significant inverse correlation with condylar AP and mediolateral dimensions. It also showed significant correlation with flattening of the TMJ condylar head and flattening of the articular fossa. Patients with high and moderate disease activity showed significantly smaller AP TMJ dimension than patients with low disease activity. Disease activity showed statistically significant direct correlation with all osteoarthritic changes except for erosions of the glenoid fossa and condyle. CONCLUSION: Disease Activity Score28 score and disease activity are strong indicators of TMJ affection in RA patients when compared to RF and ACCP. ACCP is a better indicator of changes in condylar measurements than TMJ osteoarthritic changes. While RF is the least efficient indicator of TMJ involvement in RA patients. SN - 0250-832X UR - https://www.unboundmedicine.com/medline/citation/31530023/Radiographic_changes_in_TMJ_in_relation_to_serology_and_disease_activity_in_RA_patients L2 - http://www.birpublications.org/doi/full/10.1259/dmfr.20190186?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -