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Giant hepatic hemangioma in the fetus: case reports and updated review of the literature.
J Matern Fetal Neonatal Med. 2019 Oct 03 [Online ahead of print]JM

Abstract

Objectives:

To describe three cases of giant fetal hepatic hemangioma detected by prenatal ultrasound in the third trimester of pregnancy and further confirmed by fetal magnetic resonance imaging (MRI). An updated review of the literature was also carried out.

Results:

In one case, there was an unexpected intrauterine demise at 35 weeks. The other two women delivered liveborn infants at term. The first of these two neonates had a stormy neonatal course and underwent endovascular embolization with limited clinical success. The infant presented multiple medical complications and was discharged home at five months of age. The second infant had an uneventful postnatal course. Subsequent follow-up scans showed progressive shrinkage of the lesion with no associated complications. A review of the English literature revealed a total of 42 cases prenatally diagnosed by ultrasound. The most relevant clinical and ultrasound findings are presented and the diverse perinatal outcomes related to this condition are discussed.

Conclusions:

Fetal hepatic hemangiomas are exceedingly rare vascular tumors; however, they can be associated with several life-threatening conditions. They are usually detected by ultrasound, either incidentally or in the context of nonimmune hydrops secondary to high-output cardiac failure. Our review documents the increasing role of fetal MRI in the prenatal diagnosis and management of these cases. However, the improvement in prenatal diagnostic imaging techniques has not been associated with a better perinatal prognosis in the reported cases.

Authors+Show Affiliations

Fetal Imaging Unit, FETALMED - Maternal Fetal Diagnostic Center , Santiago , Chile.Fetal Imaging Unit, FETALMED - Maternal Fetal Diagnostic Center , Santiago , Chile.Ultrasound Unit, Department of Obstetrics and Gynecology, Regional Hospital, University Diego Portales School of Medicine , Rancagua , Chile.Ultrasound Unit, Department of Obstetrics and Gynecology, Clinica Indisa , Santiago , Chile.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31530056

Citation

Sepulveda, Waldo, et al. "Giant Hepatic Hemangioma in the Fetus: Case Reports and Updated Review of the Literature." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019, pp. 1-13.
Sepulveda W, Sepulveda F, Corral E, et al. Giant hepatic hemangioma in the fetus: case reports and updated review of the literature. J Matern Fetal Neonatal Med. 2019.
Sepulveda, W., Sepulveda, F., Corral, E., & Gutierrez, J. (2019). Giant hepatic hemangioma in the fetus: case reports and updated review of the literature. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 1-13. https://doi.org/10.1080/14767058.2019.1669555
Sepulveda W, et al. Giant Hepatic Hemangioma in the Fetus: Case Reports and Updated Review of the Literature. J Matern Fetal Neonatal Med. 2019 Oct 3;1-13. PubMed PMID: 31530056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Giant hepatic hemangioma in the fetus: case reports and updated review of the literature. AU - Sepulveda,Waldo, AU - Sepulveda,Francisco, AU - Corral,Edgardo, AU - Gutierrez,Jorge, Y1 - 2019/10/03/ PY - 2019/9/19/pubmed PY - 2019/9/19/medline PY - 2019/9/19/entrez KW - Fetal hemangioma KW - fetal tumor KW - fetal ultrasound KW - hepatic hemangioma KW - magnetic resonance imaging KW - prenatal diagnosis SP - 1 EP - 13 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. N2 - Objectives: To describe three cases of giant fetal hepatic hemangioma detected by prenatal ultrasound in the third trimester of pregnancy and further confirmed by fetal magnetic resonance imaging (MRI). An updated review of the literature was also carried out. Results: In one case, there was an unexpected intrauterine demise at 35 weeks. The other two women delivered liveborn infants at term. The first of these two neonates had a stormy neonatal course and underwent endovascular embolization with limited clinical success. The infant presented multiple medical complications and was discharged home at five months of age. The second infant had an uneventful postnatal course. Subsequent follow-up scans showed progressive shrinkage of the lesion with no associated complications. A review of the English literature revealed a total of 42 cases prenatally diagnosed by ultrasound. The most relevant clinical and ultrasound findings are presented and the diverse perinatal outcomes related to this condition are discussed. Conclusions: Fetal hepatic hemangiomas are exceedingly rare vascular tumors; however, they can be associated with several life-threatening conditions. They are usually detected by ultrasound, either incidentally or in the context of nonimmune hydrops secondary to high-output cardiac failure. Our review documents the increasing role of fetal MRI in the prenatal diagnosis and management of these cases. However, the improvement in prenatal diagnostic imaging techniques has not been associated with a better perinatal prognosis in the reported cases. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/31530056/Giant_hepatic_hemangioma_in_the_fetus:_case_reports_and_updated_review_of_the_literature_ L2 - http://www.tandfonline.com/doi/full/10.1080/14767058.2019.1669555 DB - PRIME DP - Unbound Medicine ER -
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