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Efficacy of an Antiaging Treatment Against Environmental Factors: Deschampsia antarctica Extract and High-tolerance Retinoids Combination.
J Clin Aesthet Dermatol 2019; 12(7):E65-E70JC

Abstract

Background.

Effects of environmental contaminents, such as air pollution and cigarette smoking on skin include increased oxidation, subclinical inflammation, and degradation of the dermal matrix, which can accelerate the skin aging process.

Objective.

An open-label, prospective study was conducted to assess the efficacy and tolerability of a topical anti-aging regimen comprising high-concentration retinoids, Deschampsia antarctica extract, and niacinamide in participants living in a heavily polluted (Level III, World Health Organization) city. Methods. Twenty-two female Caucasian volunteers with Fitzpatrick Skin Types III and IV were treated for 90 days with the topical anti-aging regimen. Subjective clinical assessments using the Rao-Goldman Scoring for Facial Aging, Patient's Global Assessment (PGA), and Investigator's Global Assessment (IGA). Additionally, objective instrumental assessments for wrinkles using Visia® (Canfield Scientific, Parsippany, New Jersey) and Visioline® (Courage+Khazaka Electronic GmbH, Cologne, Germany) and viscoelasticity and firmness using Cutometer® (Courage+Khazaka Electronic GmbH) were completed at baseline, Day 30, and Day 90.

Results.

At Day 30, wrinkles in the periocular area significantly improved by 35.7 percent (p=0.003) compared to baseline. At the end of the study (Day 90), a significant improvement in firmness (41.7%) and viscoelasticity (12.8%) were observed. Tolerance for treatment was assessed as "good" or "very good" in 86.5 percent of the volunteers.

Conclusion.

This novel antiaging treatment regimen could potentially serve as an effective and long-term topical treatment option for improving signs of facial aging and protecting the skin from external factors associated with acceleration of the skin aging process, such exposure to UV radiation, air pollution, and cigarette smoke. Larger and longer-term, randomized, controlled clinical trials in more diverse population samples are needed to confirm our results.

Authors+Show Affiliations

Dr. Perez-Davó is with the Medical Affairs Department at Cantabria Labs in Madrid, Spain. Dr. Truchuelo is with the Vithas Nuestra Señora de América Hospital in Madrid, Spain. Dr. Vitale is with the Medical Department of Cantabria Labs in Madrid, Spain. Dr. Gonzalez-Castro is with IDERMA-Quirón Dexeus Hospital, Methodex, in Barcelona, Spain.Dr. Perez-Davó is with the Medical Affairs Department at Cantabria Labs in Madrid, Spain. Dr. Truchuelo is with the Vithas Nuestra Señora de América Hospital in Madrid, Spain. Dr. Vitale is with the Medical Department of Cantabria Labs in Madrid, Spain. Dr. Gonzalez-Castro is with IDERMA-Quirón Dexeus Hospital, Methodex, in Barcelona, Spain.Dr. Perez-Davó is with the Medical Affairs Department at Cantabria Labs in Madrid, Spain. Dr. Truchuelo is with the Vithas Nuestra Señora de América Hospital in Madrid, Spain. Dr. Vitale is with the Medical Department of Cantabria Labs in Madrid, Spain. Dr. Gonzalez-Castro is with IDERMA-Quirón Dexeus Hospital, Methodex, in Barcelona, Spain.Dr. Perez-Davó is with the Medical Affairs Department at Cantabria Labs in Madrid, Spain. Dr. Truchuelo is with the Vithas Nuestra Señora de América Hospital in Madrid, Spain. Dr. Vitale is with the Medical Department of Cantabria Labs in Madrid, Spain. Dr. Gonzalez-Castro is with IDERMA-Quirón Dexeus Hospital, Methodex, in Barcelona, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31531164

Citation

Pérez Davó, Azahara, et al. "Efficacy of an Antiaging Treatment Against Environmental Factors: Deschampsia Antarctica Extract and High-tolerance Retinoids Combination." The Journal of Clinical and Aesthetic Dermatology, vol. 12, no. 7, 2019, pp. E65-E70.
Pérez Davó A, Truchuelo MT, Vitale M, et al. Efficacy of an Antiaging Treatment Against Environmental Factors: Deschampsia antarctica Extract and High-tolerance Retinoids Combination. J Clin Aesthet Dermatol. 2019;12(7):E65-E70.
Pérez Davó, A., Truchuelo, M. T., Vitale, M., & Gonzalez-Castro, J. (2019). Efficacy of an Antiaging Treatment Against Environmental Factors: Deschampsia antarctica Extract and High-tolerance Retinoids Combination. The Journal of Clinical and Aesthetic Dermatology, 12(7), pp. E65-E70.
Pérez Davó A, et al. Efficacy of an Antiaging Treatment Against Environmental Factors: Deschampsia Antarctica Extract and High-tolerance Retinoids Combination. J Clin Aesthet Dermatol. 2019;12(7):E65-E70. PubMed PMID: 31531164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of an Antiaging Treatment Against Environmental Factors: Deschampsia antarctica Extract and High-tolerance Retinoids Combination. AU - Pérez Davó,Azahara, AU - Truchuelo,Maria Teresa, AU - Vitale,Maria, AU - Gonzalez-Castro,J, Y1 - 2019/07/01/ PY - 2019/9/19/entrez PY - 2019/9/19/pubmed PY - 2019/9/19/medline KW - Antiaging KW - cosmetic formula KW - photoaging KW - pollution KW - retinol KW - topical SP - E65 EP - E70 JF - The Journal of clinical and aesthetic dermatology JO - J Clin Aesthet Dermatol VL - 12 IS - 7 N2 - Background. Effects of environmental contaminents, such as air pollution and cigarette smoking on skin include increased oxidation, subclinical inflammation, and degradation of the dermal matrix, which can accelerate the skin aging process. Objective. An open-label, prospective study was conducted to assess the efficacy and tolerability of a topical anti-aging regimen comprising high-concentration retinoids, Deschampsia antarctica extract, and niacinamide in participants living in a heavily polluted (Level III, World Health Organization) city. Methods. Twenty-two female Caucasian volunteers with Fitzpatrick Skin Types III and IV were treated for 90 days with the topical anti-aging regimen. Subjective clinical assessments using the Rao-Goldman Scoring for Facial Aging, Patient's Global Assessment (PGA), and Investigator's Global Assessment (IGA). Additionally, objective instrumental assessments for wrinkles using Visia® (Canfield Scientific, Parsippany, New Jersey) and Visioline® (Courage+Khazaka Electronic GmbH, Cologne, Germany) and viscoelasticity and firmness using Cutometer® (Courage+Khazaka Electronic GmbH) were completed at baseline, Day 30, and Day 90. Results. At Day 30, wrinkles in the periocular area significantly improved by 35.7 percent (p=0.003) compared to baseline. At the end of the study (Day 90), a significant improvement in firmness (41.7%) and viscoelasticity (12.8%) were observed. Tolerance for treatment was assessed as "good" or "very good" in 86.5 percent of the volunteers. Conclusion. This novel antiaging treatment regimen could potentially serve as an effective and long-term topical treatment option for improving signs of facial aging and protecting the skin from external factors associated with acceleration of the skin aging process, such exposure to UV radiation, air pollution, and cigarette smoke. Larger and longer-term, randomized, controlled clinical trials in more diverse population samples are needed to confirm our results. SN - 1941-2789 UR - https://www.unboundmedicine.com/medline/citation/31531164/Efficacy_of_an_Antiaging_Treatment_Against_Environmental_Factors:_Deschampsia_antarctica_Extract_and_High-tolerance_Retinoids_Combination L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31531164/ DB - PRIME DP - Unbound Medicine ER -