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Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus on Choroidal Thickness and Axial Length in Young Myopic Adults.
J Ophthalmol. 2019; 2019:4782536.JO

Abstract

Purpose

To examine the interaction between a short period of hyperopic defocus and low-dose atropine upon the choroidal thickness and ocular biometrics of healthy myopic subjects.

Methods

Twenty young adult myopic subjects had subfoveal choroidal thickness (ChT) and ocular biometry measurements taken before and 30 and 60 min following the introduction of optical blur (0.00 D and -3.00 D) combined with administration of 0.01% atropine or placebo. Each combination of optical blur and drug was tested on different days in a fixed order.

Results

The choroid exhibited significant thinning after imposing hyperopic defocus combined with placebo (mean change of -11 ± 2 μm, p < 0.001). The combination of hyperopic blur and 0.01% atropine led to a significantly smaller magnitude of subfoveal choroidal thinning (-4 ± 8 μm), compared to placebo and hyperopic defocus (p < 0.01). Eyes treated with 0.01% atropine with no defocus exhibited a significant increase in ChT (+6 ± 2 μm, p < 0.01). Axial length also underwent small but significant changes after treatment with hyperopic blur and placebo and 0.01% atropine alone (both p < 0.01), but of opposite direction to the changes in choroidal thickness. However, the 0.01% atropine/hyperopic blur condition did not lead to a significant change in axial length compared to baseline (p > 0.05).

Conclusion

Low-dose atropine does inhibit the short-term effect of hyperopic blur on choroidal thickness and, when used alone, does cause a slight thickening of the choroid in young healthy myopic adults.

Authors+Show Affiliations

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Victoria Park Road, Kelvin Grove 4059, Brisbane, Queensland, Australia.Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Victoria Park Road, Kelvin Grove 4059, Brisbane, Queensland, Australia.Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Victoria Park Road, Kelvin Grove 4059, Brisbane, Queensland, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31531235

Citation

Sander, Beata P., et al. "Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus On Choroidal Thickness and Axial Length in Young Myopic Adults." Journal of Ophthalmology, vol. 2019, 2019, p. 4782536.
Sander BP, Collins MJ, Read SA. Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus on Choroidal Thickness and Axial Length in Young Myopic Adults. Journal of ophthalmology. 2019;2019:4782536.
Sander, B. P., Collins, M. J., & Read, S. A. (2019). Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus on Choroidal Thickness and Axial Length in Young Myopic Adults. Journal of Ophthalmology, 2019, 4782536. https://doi.org/10.1155/2019/4782536
Sander BP, Collins MJ, Read SA. Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus On Choroidal Thickness and Axial Length in Young Myopic Adults. Journal of ophthalmology. 2019;2019:4782536. PubMed PMID: 31531235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus on Choroidal Thickness and Axial Length in Young Myopic Adults. AU - Sander,Beata P, AU - Collins,Michael J, AU - Read,Scott A, Y1 - 2019/08/21/ PY - 2019/02/13/received PY - 2019/04/25/revised PY - 2019/05/28/accepted PY - 2019/9/19/entrez PY - 2019/9/19/pubmed PY - 2019/9/19/medline SP - 4782536 EP - 4782536 JF - Journal of ophthalmology VL - 2019 N2 - Purpose: To examine the interaction between a short period of hyperopic defocus and low-dose atropine upon the choroidal thickness and ocular biometrics of healthy myopic subjects. Methods: Twenty young adult myopic subjects had subfoveal choroidal thickness (ChT) and ocular biometry measurements taken before and 30 and 60 min following the introduction of optical blur (0.00 D and -3.00 D) combined with administration of 0.01% atropine or placebo. Each combination of optical blur and drug was tested on different days in a fixed order. Results: The choroid exhibited significant thinning after imposing hyperopic defocus combined with placebo (mean change of -11 ± 2 μm, p < 0.001). The combination of hyperopic blur and 0.01% atropine led to a significantly smaller magnitude of subfoveal choroidal thinning (-4 ± 8 μm), compared to placebo and hyperopic defocus (p < 0.01). Eyes treated with 0.01% atropine with no defocus exhibited a significant increase in ChT (+6 ± 2 μm, p < 0.01). Axial length also underwent small but significant changes after treatment with hyperopic blur and placebo and 0.01% atropine alone (both p < 0.01), but of opposite direction to the changes in choroidal thickness. However, the 0.01% atropine/hyperopic blur condition did not lead to a significant change in axial length compared to baseline (p > 0.05). Conclusion: Low-dose atropine does inhibit the short-term effect of hyperopic blur on choroidal thickness and, when used alone, does cause a slight thickening of the choroid in young healthy myopic adults. SN - 2090-004X UR - https://www.unboundmedicine.com/medline/citation/31531235/Short_Term_Effect_of_Low_Dose_Atropine_and_Hyperopic_Defocus_on_Choroidal_Thickness_and_Axial_Length_in_Young_Myopic_Adults_ L2 - https://doi.org/10.1155/2019/4782536 DB - PRIME DP - Unbound Medicine ER -
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