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Primary malignant melanoma of the biliary tract: A case report and literature review.
World J Clin Cases 2019; 7(16):2302-2308WJ

Abstract

BACKGROUND

Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another location. This paper reviews the most important characteristics of MBT cases published in the literature and reports a new case. The patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with immunotherapy. This patient remains disease-free 36 mo after the treatment of metastatic lung lesions.

CASE SUMMARY

A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical course. Magnetic resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic duct. Given the suspicion of biliary tract neoplasia, cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of complications. Anatomo-pathological diagnosis was melanoma. After intervention, the patient was referred to the Department of Medical Oncology, where a primary origin was excluded in the skin, mucosa, and eyes. This confirmed diagnosis of primary biliary tract melanoma. Computed tomography was performed 12 mo after the procedure revealed several subcentimetric lung nodules. Wedge resection was performed. After confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract, the patient was started on immunotherapy with nivolumab. Tolerance to treatment was excellent. The patient remains disease-free 36 mo after the treatment of metastatic lung lesions.

CONCLUSION

The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy.

Authors+Show Affiliations

Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain. soledad.cameselle.garcia@sergas.es.Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain.Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain.Department of Digestive, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain.Department of Pathology, Hospital San Rafael, A Coruña 15009, Spain.Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31531323

Citation

Cameselle-García, Soledad, et al. "Primary Malignant Melanoma of the Biliary Tract: a Case Report and Literature Review." World Journal of Clinical Cases, vol. 7, no. 16, 2019, pp. 2302-2308.
Cameselle-García S, Pérez JLF, Areses MC, et al. Primary malignant melanoma of the biliary tract: A case report and literature review. World J Clin Cases. 2019;7(16):2302-2308.
Cameselle-García, S., Pérez, J. L. F., Areses, M. C., de Castro, J. D. F., Mosquera-Reboredo, J., & García-Mata, J. (2019). Primary malignant melanoma of the biliary tract: A case report and literature review. World Journal of Clinical Cases, 7(16), pp. 2302-2308. doi:10.12998/wjcc.v7.i16.2302.
Cameselle-García S, et al. Primary Malignant Melanoma of the Biliary Tract: a Case Report and Literature Review. World J Clin Cases. 2019 Aug 26;7(16):2302-2308. PubMed PMID: 31531323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary malignant melanoma of the biliary tract: A case report and literature review. AU - Cameselle-García,Soledad, AU - Pérez,José Luis Fírvida, AU - Areses,María C, AU - de Castro,Jesús Daniel Fernández, AU - Mosquera-Reboredo,Juan, AU - García-Mata,Jesús, PY - 2019/03/25/received PY - 2019/06/29/revised PY - 2019/07/27/accepted PY - 2019/9/19/entrez PY - 2019/9/19/pubmed PY - 2019/9/19/medline KW - Biliary tract KW - Case report KW - Immunotherapy KW - Malignant melanoma SP - 2302 EP - 2308 JF - World journal of clinical cases JO - World J Clin Cases VL - 7 IS - 16 N2 - BACKGROUND: Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another location. This paper reviews the most important characteristics of MBT cases published in the literature and reports a new case. The patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with immunotherapy. This patient remains disease-free 36 mo after the treatment of metastatic lung lesions. CASE SUMMARY: A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical course. Magnetic resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic duct. Given the suspicion of biliary tract neoplasia, cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of complications. Anatomo-pathological diagnosis was melanoma. After intervention, the patient was referred to the Department of Medical Oncology, where a primary origin was excluded in the skin, mucosa, and eyes. This confirmed diagnosis of primary biliary tract melanoma. Computed tomography was performed 12 mo after the procedure revealed several subcentimetric lung nodules. Wedge resection was performed. After confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract, the patient was started on immunotherapy with nivolumab. Tolerance to treatment was excellent. The patient remains disease-free 36 mo after the treatment of metastatic lung lesions. CONCLUSION: The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy. SN - 2307-8960 UR - https://www.unboundmedicine.com/medline/citation/31531323/Primary_malignant_melanoma_of_the_biliary_tract:_A_case_report_and_literature_review L2 - http://www.wjgnet.com/2307-8960/full/v7/i16/2302.htm DB - PRIME DP - Unbound Medicine ER -