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Combined deficiency of coagulation factors II, VII, IX, and X: a case of probable congenital origin.

Abstract

Combined deficiency of coagulant activity of the vitamin K-dependent factors was found in a 14-year-old boy suffering from severe hemorrhages. Immunoassays revealed the presence of acarboxyprothrombin. The bleedings could be controlled, but the coagulation defects persisted during more than 2 years' follow-up and could not be corrected by oral or parenteral vitamin K. No intoxication or underlying disease was found. The abnormality was considered a congenital disorder of the carboxylation of prothrombin.

Authors+Show Affiliations

,

Department of Paediatrics, Ostra Sjukhuset, Göteborg, Sweden.

,

Source

MeSH

Adolescent
Blood Coagulation Factors
Factor VII Deficiency
Factor X Deficiency
Follow-Up Studies
Hemophilia B
Hemorrhagic Disorders
Humans
Hypoprothrombinemias
Male
Protein Processing, Post-Translational
Prothrombin
Vitamin K

Pub Type(s)

Case Reports
Letter

Language

eng

PubMed ID

3153231

Citation

Ekelund, H, et al. "Combined Deficiency of Coagulation Factors II, VII, IX, and X: a Case of Probable Congenital Origin." Pediatric Hematology and Oncology, vol. 3, no. 2, 1986, pp. 187-93.
Ekelund H, Lindeberg L, Wranne L. Combined deficiency of coagulation factors II, VII, IX, and X: a case of probable congenital origin. Pediatr Hematol Oncol. 1986;3(2):187-93.
Ekelund, H., Lindeberg, L., & Wranne, L. (1986). Combined deficiency of coagulation factors II, VII, IX, and X: a case of probable congenital origin. Pediatric Hematology and Oncology, 3(2), pp. 187-93.
Ekelund H, Lindeberg L, Wranne L. Combined Deficiency of Coagulation Factors II, VII, IX, and X: a Case of Probable Congenital Origin. Pediatr Hematol Oncol. 1986;3(2):187-93. PubMed PMID: 3153231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined deficiency of coagulation factors II, VII, IX, and X: a case of probable congenital origin. AU - Ekelund,H, AU - Lindeberg,L, AU - Wranne,L, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 187 EP - 93 JF - Pediatric hematology and oncology JO - Pediatr Hematol Oncol VL - 3 IS - 2 N2 - Combined deficiency of coagulant activity of the vitamin K-dependent factors was found in a 14-year-old boy suffering from severe hemorrhages. Immunoassays revealed the presence of acarboxyprothrombin. The bleedings could be controlled, but the coagulation defects persisted during more than 2 years' follow-up and could not be corrected by oral or parenteral vitamin K. No intoxication or underlying disease was found. The abnormality was considered a congenital disorder of the carboxylation of prothrombin. SN - 0888-0018 UR - https://www.unboundmedicine.com/medline/citation/3153231/Combined_deficiency_of_coagulation_factors_II_VII_IX_and_X:_a_case_of_probable_congenital_origin_ L2 - https://medlineplus.gov/vitamink.html DB - PRIME DP - Unbound Medicine ER -