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Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin.
J Cosmet Dermatol. 2020 Jun; 19(6):1399-1403.JC

Abstract

BACKGROUND

The stratum corneum plays an important protective physiological role in providing a barrier to preventing skin desiccation and penetration of external agents. Emollients are used commonly to improve barrier function and skin hydration.

AIMS

The primary objective of this study was to evaluate the effect of an emollient, V0034CR cream, and its active ingredients, to restore the cutaneous barrier. Secondary objectives included assessment of the moisturizing activity of each product and tolerance. The study was not designed to evaluate therapeutic benefit.

METHODS

In this randomized, double-blind, 4-arm crossover, clinical pharmacology study, the full emollient V0034CR, its vehicle formulation alone, or with glycerol, or petrolatum, was applied to the forearms of healthy volunteers (n = 51) with dry skin (Kligman score of 2 or 3). Cutaneous permeability by Trans Epidermal Water Loss (TEWL) and skin moisture content by corneometry were serially measured for 12 hours following application. An analysis of variance with repeated measures was performed on the evolution of TEWL and corneometry.

RESULTS

V0034CR emollient significantly reduced mean TEWL compared to vehicle (P = .0018) and vehicle + glycerol (P = .0001) and significantly increased mean corneometry scores compared to vehicle (P < .0001) and vehicle + petrolatum (P < .0001).

CONCLUSIONS

The emollient V0034CR presented combined effects, with the petrolatum component improving skin barrier function, with a reduction in TEWL, and the glycerol component improving skin hydration.

Authors+Show Affiliations

CHRU Dermatology Department, University of Tours, INSERM U 1253 iBrain, Tours, France.CHRU Dermatology Department, University of Tours, INSERM U 1253 iBrain, Tours, France.Dermatology Department, Hôpital des Peupliers, Paris, France.Pierre Fabre Dermatologie, Lavaur, France.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31532576

Citation

Vaillant, Loïc, et al. "Combined Effects of Glycerol and Petrolatum in an Emollient Cream: a Randomized, Double-blind, Crossover Study in Healthy Volunteers With Dry Skin." Journal of Cosmetic Dermatology, vol. 19, no. 6, 2020, pp. 1399-1403.
Vaillant L, Georgescou G, Rivollier C, et al. Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin. J Cosmet Dermatol. 2020;19(6):1399-1403.
Vaillant, L., Georgescou, G., Rivollier, C., & Delarue, A. (2020). Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin. Journal of Cosmetic Dermatology, 19(6), 1399-1403. https://doi.org/10.1111/jocd.13163
Vaillant L, et al. Combined Effects of Glycerol and Petrolatum in an Emollient Cream: a Randomized, Double-blind, Crossover Study in Healthy Volunteers With Dry Skin. J Cosmet Dermatol. 2020;19(6):1399-1403. PubMed PMID: 31532576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin. AU - Vaillant,Loïc, AU - Georgescou,Gabriela, AU - Rivollier,Constance, AU - Delarue,Alain, Y1 - 2019/09/18/ PY - 2019/06/27/received PY - 2019/09/03/revised PY - 2019/09/05/accepted PY - 2019/9/19/pubmed PY - 2021/2/9/medline PY - 2019/9/19/entrez KW - Trans Epidermal Water Loss KW - corneometry KW - emollient KW - skin barrier function KW - skin hydration SP - 1399 EP - 1403 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 19 IS - 6 N2 - BACKGROUND: The stratum corneum plays an important protective physiological role in providing a barrier to preventing skin desiccation and penetration of external agents. Emollients are used commonly to improve barrier function and skin hydration. AIMS: The primary objective of this study was to evaluate the effect of an emollient, V0034CR cream, and its active ingredients, to restore the cutaneous barrier. Secondary objectives included assessment of the moisturizing activity of each product and tolerance. The study was not designed to evaluate therapeutic benefit. METHODS: In this randomized, double-blind, 4-arm crossover, clinical pharmacology study, the full emollient V0034CR, its vehicle formulation alone, or with glycerol, or petrolatum, was applied to the forearms of healthy volunteers (n = 51) with dry skin (Kligman score of 2 or 3). Cutaneous permeability by Trans Epidermal Water Loss (TEWL) and skin moisture content by corneometry were serially measured for 12 hours following application. An analysis of variance with repeated measures was performed on the evolution of TEWL and corneometry. RESULTS: V0034CR emollient significantly reduced mean TEWL compared to vehicle (P = .0018) and vehicle + glycerol (P = .0001) and significantly increased mean corneometry scores compared to vehicle (P < .0001) and vehicle + petrolatum (P < .0001). CONCLUSIONS: The emollient V0034CR presented combined effects, with the petrolatum component improving skin barrier function, with a reduction in TEWL, and the glycerol component improving skin hydration. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/31532576/Combined_effects_of_glycerol_and_petrolatum_in_an_emollient_cream:_A_randomized_double_blind_crossover_study_in_healthy_volunteers_with_dry_skin_ L2 - https://doi.org/10.1111/jocd.13163 DB - PRIME DP - Unbound Medicine ER -