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The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation.
Mol Nutr Food Res 2019; 63(24):e1900399MN

Abstract

SCOPE

A better understanding of factors contributing to interindividual variability in biomarkers of vitamin K can enhance the understanding of the equivocal role of vitamin K in cardiovascular disease. Based on the known biology of phylloquinone, the major form of vitamin K, it is hypothesized that plasma lipids contribute to the variable response of biomarkers of vitamin K metabolism to phylloquinone supplementation.

METHODS AND RESULTS

The association of plasma lipids and 27 lipid-related genetic variants with the response of biomarkers of vitamin K metabolism is examined in a secondary analysis of data from a 3-year phylloquinone supplementation trial in men (n = 66) and women (n = 85). Year 3 plasma triglycerides (TG), but not total cholesterol, LDL-cholesterol, or HDL-cholesterol, are associated with the plasma phylloquinone response (men: β = 1.01, p < 0.001, R2 = 0.34; women: β = 0.61, p = 0.008, R2 = 0.11; sex interaction p = 0.077). Four variants and the TG-weighted genetic risk score are associated with the plasma phylloquinone response in men only. Plasma lipids are not associated with changes in biomarkers of vitamin K function (undercarboxylated osteocalcin and matrix gla protein) in either sex.

CONCLUSION

Plasma TG are an important determinant of the interindividual response of plasma phylloquinone to phylloquinone supplementation, but changes in biomarkers of vitamin K carboxylation are not influenced by lipids.

Authors+Show Affiliations

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA.Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA.Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA.Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA.Molecular Cardiology Research Institute Center for Translational Genomics, Tufts Medical Center and Tufts University, Boston, MA, 02111, USA.Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA.Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, 02111, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31533195

Citation

Kelly, Jennifer M., et al. "The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation." Molecular Nutrition & Food Research, vol. 63, no. 24, 2019, pp. e1900399.
Kelly JM, Ordovas JM, Matuszek G, et al. The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation. Mol Nutr Food Res. 2019;63(24):e1900399.
Kelly, J. M., Ordovas, J. M., Matuszek, G., Smith, C. E., Huggins, G. S., Dashti, H. S., ... Booth, S. L. (2019). The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation. Molecular Nutrition & Food Research, 63(24), pp. e1900399. doi:10.1002/mnfr.201900399.
Kelly JM, et al. The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation. Mol Nutr Food Res. 2019;63(24):e1900399. PubMed PMID: 31533195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation. AU - Kelly,Jennifer M, AU - Ordovas,Jose M, AU - Matuszek,Gregory, AU - Smith,Caren E, AU - Huggins,Gordon S, AU - Dashti,Hassan S, AU - Ichikawa,Reiko, AU - Booth,Sarah L, Y1 - 2019/10/03/ PY - 2019/04/18/received PY - 2019/08/16/revised PY - 2019/9/19/pubmed PY - 2019/9/19/medline PY - 2019/9/19/entrez KW - cardiovascular disease KW - lipids KW - phylloquinone KW - vitamin K SP - e1900399 EP - e1900399 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 63 IS - 24 N2 - SCOPE: A better understanding of factors contributing to interindividual variability in biomarkers of vitamin K can enhance the understanding of the equivocal role of vitamin K in cardiovascular disease. Based on the known biology of phylloquinone, the major form of vitamin K, it is hypothesized that plasma lipids contribute to the variable response of biomarkers of vitamin K metabolism to phylloquinone supplementation. METHODS AND RESULTS: The association of plasma lipids and 27 lipid-related genetic variants with the response of biomarkers of vitamin K metabolism is examined in a secondary analysis of data from a 3-year phylloquinone supplementation trial in men (n = 66) and women (n = 85). Year 3 plasma triglycerides (TG), but not total cholesterol, LDL-cholesterol, or HDL-cholesterol, are associated with the plasma phylloquinone response (men: β = 1.01, p < 0.001, R2 = 0.34; women: β = 0.61, p = 0.008, R2 = 0.11; sex interaction p = 0.077). Four variants and the TG-weighted genetic risk score are associated with the plasma phylloquinone response in men only. Plasma lipids are not associated with changes in biomarkers of vitamin K function (undercarboxylated osteocalcin and matrix gla protein) in either sex. CONCLUSION: Plasma TG are an important determinant of the interindividual response of plasma phylloquinone to phylloquinone supplementation, but changes in biomarkers of vitamin K carboxylation are not influenced by lipids. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/31533195/The_Contribution_of_Lipids_to_the_Interindividual_Response_of_Vitamin_K_Biomarkers_to_Vitamin_K_Supplementation L2 - https://doi.org/10.1002/mnfr.201900399 DB - PRIME DP - Unbound Medicine ER -