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Coordinating septum formation and the actomyosin ring during cytokinesis in Schizosaccharomyces pombe.

Abstract

During cytokinesis, animal and fungal cells form a membrane furrow via actomyosin ring constriction. Our understanding of actomyosin ring-driven cytokinesis stems extensively from the fission yeast model system. However, unlike animal cells, actomyosin ring constriction occurs simultaneously with septum formation in fungi. While the formation of an actomyosin ring is essential for cytokinesis in fission yeast, proper furrow formation also requires septum deposition. The molecular mechanisms of spatiotemporal coordination of septum deposition with actomyosin ring constriction are poorly understood. Although the role of the actomyosin ring as a mechanical structure driving furrow formation is better understood, its role as a spatiotemporal landmark for septum deposition is not widely discussed. Here we review and discuss the recent advances describing how the actomyosin ring spatiotemporally regulates membrane traffic to promote septum-driven cytokinesis in fission yeast. Finally, we explore emerging questions in cytokinesis, and discuss the role of extracellular matrix during cytokinesis in other organisms.

Authors+Show Affiliations

Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 37996, USA.Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 37996, USA.Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 37996, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31533197

Citation

Hercyk, Brian S., et al. "Coordinating Septum Formation and the Actomyosin Ring During Cytokinesis in Schizosaccharomyces Pombe." Molecular Microbiology, 2019.
Hercyk BS, Onwubiko UN, Das ME. Coordinating septum formation and the actomyosin ring during cytokinesis in Schizosaccharomyces pombe. Mol Microbiol. 2019.
Hercyk, B. S., Onwubiko, U. N., & Das, M. E. (2019). Coordinating septum formation and the actomyosin ring during cytokinesis in Schizosaccharomyces pombe. Molecular Microbiology, doi:10.1111/mmi.14387.
Hercyk BS, Onwubiko UN, Das ME. Coordinating Septum Formation and the Actomyosin Ring During Cytokinesis in Schizosaccharomyces Pombe. Mol Microbiol. 2019 Sep 18; PubMed PMID: 31533197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coordinating septum formation and the actomyosin ring during cytokinesis in Schizosaccharomyces pombe. AU - Hercyk,Brian S, AU - Onwubiko,Udo N, AU - Das,Maitreyi E, Y1 - 2019/09/18/ PY - 2019/09/12/accepted PY - 2019/9/19/pubmed PY - 2019/9/19/medline PY - 2019/9/19/entrez JF - Molecular microbiology JO - Mol. Microbiol. N2 - During cytokinesis, animal and fungal cells form a membrane furrow via actomyosin ring constriction. Our understanding of actomyosin ring-driven cytokinesis stems extensively from the fission yeast model system. However, unlike animal cells, actomyosin ring constriction occurs simultaneously with septum formation in fungi. While the formation of an actomyosin ring is essential for cytokinesis in fission yeast, proper furrow formation also requires septum deposition. The molecular mechanisms of spatiotemporal coordination of septum deposition with actomyosin ring constriction are poorly understood. Although the role of the actomyosin ring as a mechanical structure driving furrow formation is better understood, its role as a spatiotemporal landmark for septum deposition is not widely discussed. Here we review and discuss the recent advances describing how the actomyosin ring spatiotemporally regulates membrane traffic to promote septum-driven cytokinesis in fission yeast. Finally, we explore emerging questions in cytokinesis, and discuss the role of extracellular matrix during cytokinesis in other organisms. SN - 1365-2958 UR - https://www.unboundmedicine.com/medline/citation/31533197/Coordinating_septum_formation_and_the_actomyosin_ring_during_cytokinesis_in_Schizosaccharomyces_pombe L2 - https://doi.org/10.1111/mmi.14387 DB - PRIME DP - Unbound Medicine ER -