Tags

Type your tag names separated by a space and hit enter

RP-HPLC-based phytochemical analysis and diverse pharmacological evaluation of Quercus floribunda Lindl. ex A. Camus nuts extracts.
Nat Prod Res. 2021 Jul; 35(13):2257-2262.NP

Abstract

Quercus floribunda Lindl. ex A. Camus nuts have important folklore uses, assessed for underexplored biological potential. Nuts galls or cores and coats were utilized for the preparation of extracts using 14 solvent systems. Antioxidant, antimicrobial, cytotoxic and enzyme inhibition assays along with phytochemical profiling was carried out. Distilled water cores extract demonstrated maximum percent yield, phenolics content and total antioxidant capacity. Methanol: ethyl acetate cores extract showed maximum flavonoids content, total reducing power and protein kinase inhibition. Highest percentage radical scavenging and brine shrimp lethality was revealed by acetone: distilled water cores extract. Ethyl acetate cores extract indicated maximum α-amylase inhibition. Methanol: water coats extract showed substantial leishmanial growth inhibition. n-Hexane and chloroform coats extracts showed maximum cytotoxicity against HepG2 and THP-1 cell lines, respectively. Polyphenols quantified through RP-HPLC analysis were quercetin, pyrocatechol, gallic acid, catechin and chlorogenic acid ranging from 0.003 ± 0.001 to 1.785 ± 0.5 μg/mg extract.

Authors+Show Affiliations

Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, H 8/4, Islamabad 44000, Pakistan. Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.H.E.J. Research Institute of Chemistry (Biotechnology Wing), International Centre for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.Institute of Sustainable Halophyte Utilization, University of Karachi, Karachi 75270, Pakistan.Institute of Sustainable Halophyte Utilization, University of Karachi, Karachi 75270, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31533474

Citation

Ahmed, Madiha, et al. "RP-HPLC-based Phytochemical Analysis and Diverse Pharmacological Evaluation of Quercus Floribunda Lindl. Ex A. Camus Nuts Extracts." Natural Product Research, vol. 35, no. 13, 2021, pp. 2257-2262.
Ahmed M, Adil M, Haq IU, et al. RP-HPLC-based phytochemical analysis and diverse pharmacological evaluation of Quercus floribunda Lindl. ex A. Camus nuts extracts. Nat Prod Res. 2021;35(13):2257-2262.
Ahmed, M., Adil, M., Haq, I. U., Tipu, M. K., Qasim, M., & Gul, B. (2021). RP-HPLC-based phytochemical analysis and diverse pharmacological evaluation of Quercus floribunda Lindl. ex A. Camus nuts extracts. Natural Product Research, 35(13), 2257-2262. https://doi.org/10.1080/14786419.2019.1667347
Ahmed M, et al. RP-HPLC-based Phytochemical Analysis and Diverse Pharmacological Evaluation of Quercus Floribunda Lindl. Ex A. Camus Nuts Extracts. Nat Prod Res. 2021;35(13):2257-2262. PubMed PMID: 31533474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - RP-HPLC-based phytochemical analysis and diverse pharmacological evaluation of Quercus floribunda Lindl. ex A. Camus nuts extracts. AU - Ahmed,Madiha, AU - Adil,Muhammad, AU - Haq,Ihsan-Ul-, AU - Tipu,Muhammad Khalid, AU - Qasim,Muhammad, AU - Gul,Bilquees, Y1 - 2019/09/19/ PY - 2019/9/20/pubmed PY - 2021/7/8/medline PY - 2019/9/20/entrez KW - Anticancer KW - Q. floribunda KW - antileishmanial KW - antioxidant KW - enzyme inhibition SP - 2257 EP - 2262 JF - Natural product research JO - Nat Prod Res VL - 35 IS - 13 N2 - Quercus floribunda Lindl. ex A. Camus nuts have important folklore uses, assessed for underexplored biological potential. Nuts galls or cores and coats were utilized for the preparation of extracts using 14 solvent systems. Antioxidant, antimicrobial, cytotoxic and enzyme inhibition assays along with phytochemical profiling was carried out. Distilled water cores extract demonstrated maximum percent yield, phenolics content and total antioxidant capacity. Methanol: ethyl acetate cores extract showed maximum flavonoids content, total reducing power and protein kinase inhibition. Highest percentage radical scavenging and brine shrimp lethality was revealed by acetone: distilled water cores extract. Ethyl acetate cores extract indicated maximum α-amylase inhibition. Methanol: water coats extract showed substantial leishmanial growth inhibition. n-Hexane and chloroform coats extracts showed maximum cytotoxicity against HepG2 and THP-1 cell lines, respectively. Polyphenols quantified through RP-HPLC analysis were quercetin, pyrocatechol, gallic acid, catechin and chlorogenic acid ranging from 0.003 ± 0.001 to 1.785 ± 0.5 μg/mg extract. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/31533474/RP_HPLC_based_phytochemical_analysis_and_diverse_pharmacological_evaluation_of_Quercus_floribunda_Lindl__ex_A__Camus_nuts_extracts_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1667347 DB - PRIME DP - Unbound Medicine ER -