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Comparison of low dose versus ultra-low dose hormone therapy in menopausal symptoms and quality of life in perimenopause women.
Gynecol Endocrinol 2019; :1-5GE

Abstract

The study was to compare the efficacy, safety, and tolerability of low dose versus ultra-low dose hormone therapy (HT) in the management of perimenopause symptoms and quality of life. Retrospective analysis of perimenopause patients prescribed for 25 weeks HT in the outpatient clinic of menopause. A total of 132 perimenopause women were included in two treatment regimens: one with low dose HT (LD-HT) and one with ultra-low dose HT (ULD-HT). Changes in serum levels of follicle-stimulating hormone, estradiol as well as transvaginal ultrasound (TVUS), the 36-item Short Form Health Survey (SF-36), the Kupperman Index (KI), and adverse effects were assessed at baseline, 4, 13, and 25 weeks. By the end of 25 weeks of treatment, each score of SF-36 domains for both LD-HT and ULD-HT groups were increased, the KI decreased, and the endometrial thickness increased in both groups and there was no statistical difference between two groups. Both groups have negligible differences in incidence of adverse effects. Low dose and ultra-low dose HT both can serve in improving symptoms of perimenopause, thereby offering a better quality of life with decreased incidence of side effects. Ultra-low dose treatment may have a better advantage on safety and tolerance.

Authors+Show Affiliations

Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Zhejiang Cancer Hospital , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31538509

Citation

Song, Yang, et al. "Comparison of Low Dose Versus Ultra-low Dose Hormone Therapy in Menopausal Symptoms and Quality of Life in Perimenopause Women." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 2019, pp. 1-5.
Song Y, Xu W, Chatooah ND, et al. Comparison of low dose versus ultra-low dose hormone therapy in menopausal symptoms and quality of life in perimenopause women. Gynecol Endocrinol. 2019.
Song, Y., Xu, W., Chatooah, N. D., Chen, J., Huang, Y., Chen, P., ... Zhou, J. (2019). Comparison of low dose versus ultra-low dose hormone therapy in menopausal symptoms and quality of life in perimenopause women. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, pp. 1-5. doi:10.1080/09513590.2019.1666815.
Song Y, et al. Comparison of Low Dose Versus Ultra-low Dose Hormone Therapy in Menopausal Symptoms and Quality of Life in Perimenopause Women. Gynecol Endocrinol. 2019 Sep 20;1-5. PubMed PMID: 31538509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of low dose versus ultra-low dose hormone therapy in menopausal symptoms and quality of life in perimenopause women. AU - Song,Yang, AU - Xu,Wenxian, AU - Chatooah,Namratta Devi, AU - Chen,Jianfang, AU - Huang,Yizhou, AU - Chen,Peiqiong, AU - Lan,Yibing, AU - Li,Chunming, AU - Ying,Qian, AU - Ma,Linjuan, AU - Zhou,Jianhong, Y1 - 2019/09/20/ PY - 2019/9/21/entrez KW - Perimenopause period KW - hormone therapy KW - low dose KW - quality of life KW - ultra-low dose SP - 1 EP - 5 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. N2 - The study was to compare the efficacy, safety, and tolerability of low dose versus ultra-low dose hormone therapy (HT) in the management of perimenopause symptoms and quality of life. Retrospective analysis of perimenopause patients prescribed for 25 weeks HT in the outpatient clinic of menopause. A total of 132 perimenopause women were included in two treatment regimens: one with low dose HT (LD-HT) and one with ultra-low dose HT (ULD-HT). Changes in serum levels of follicle-stimulating hormone, estradiol as well as transvaginal ultrasound (TVUS), the 36-item Short Form Health Survey (SF-36), the Kupperman Index (KI), and adverse effects were assessed at baseline, 4, 13, and 25 weeks. By the end of 25 weeks of treatment, each score of SF-36 domains for both LD-HT and ULD-HT groups were increased, the KI decreased, and the endometrial thickness increased in both groups and there was no statistical difference between two groups. Both groups have negligible differences in incidence of adverse effects. Low dose and ultra-low dose HT both can serve in improving symptoms of perimenopause, thereby offering a better quality of life with decreased incidence of side effects. Ultra-low dose treatment may have a better advantage on safety and tolerance. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/31538509/Comparison_of_low_dose_versus_ultra-low_dose_hormone_therapy_in_menopausal_symptoms_and_quality_of_life_in_perimenopause_women L2 - http://www.tandfonline.com/doi/full/10.1080/09513590.2019.1666815 DB - PRIME DP - Unbound Medicine ER -