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Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer.
Steroids 2019; 152:108498S

Abstract

Laryngeal squamous cell carcinoma (LSCC) has been shown to respond to 17β-estradiol. However, the presence and characterization of estrogen receptors (ER) and other sex hormone receptors in LSCC are still being determined. Sex hormone receptors and the way sex hormones impact LSCC tumors are important for understanding which patients would benefit from hormone therapies, such as anti-estrogen therapies. This information also has prognostic value, as there may be a correlation between ER profiles and LSCC aggression. Recent work by our team and others has shown that the canonical ER, estrogen receptor α (ERα), and its splice variant ERα36, are important modulators of estrogen signaling in LSCC. This review describes some common 17β-estradiol signaling pathways, and explains how these signaling pathways might control LSCC tumor growth. We also show that loss of ERα, but not ERα36, imbues LSCC with enhanced aggression, a pattern which has previously only been observed in breast cancer. We make a case for using ERα as a tumorigenic modulator and pathogenic marker in LSCC on par with the use of ERα as a prognostic marker in breast cancer.

Authors+Show Affiliations

Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.Department of Otolaryngology, Meir Hospital, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Otolaryngology - Head and Neck Surgery and Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA.Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA; Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address: zschwartz@vcu.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31539535

Citation

Verma, Anjali, et al. "Estrogen Signaling and Estrogen Receptors as Prognostic Indicators in Laryngeal Cancer." Steroids, vol. 152, 2019, p. 108498.
Verma A, Schwartz N, Cohen DJ, et al. Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer. Steroids. 2019;152:108498.
Verma, A., Schwartz, N., Cohen, D. J., Boyan, B. D., & Schwartz, Z. (2019). Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer. Steroids, 152, p. 108498. doi:10.1016/j.steroids.2019.108498.
Verma A, et al. Estrogen Signaling and Estrogen Receptors as Prognostic Indicators in Laryngeal Cancer. Steroids. 2019 Sep 17;152:108498. PubMed PMID: 31539535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer. AU - Verma,Anjali, AU - Schwartz,Nofrat, AU - Cohen,D Joshua, AU - Boyan,Barbara D, AU - Schwartz,Zvi, Y1 - 2019/09/17/ PY - 2019/03/18/received PY - 2019/09/03/revised PY - 2019/09/09/accepted PY - 2019/9/21/pubmed PY - 2019/9/21/medline PY - 2019/9/21/entrez KW - ERα36 KW - Estrogen receptor α KW - Laryngeal cancer SP - 108498 EP - 108498 JF - Steroids JO - Steroids VL - 152 N2 - Laryngeal squamous cell carcinoma (LSCC) has been shown to respond to 17β-estradiol. However, the presence and characterization of estrogen receptors (ER) and other sex hormone receptors in LSCC are still being determined. Sex hormone receptors and the way sex hormones impact LSCC tumors are important for understanding which patients would benefit from hormone therapies, such as anti-estrogen therapies. This information also has prognostic value, as there may be a correlation between ER profiles and LSCC aggression. Recent work by our team and others has shown that the canonical ER, estrogen receptor α (ERα), and its splice variant ERα36, are important modulators of estrogen signaling in LSCC. This review describes some common 17β-estradiol signaling pathways, and explains how these signaling pathways might control LSCC tumor growth. We also show that loss of ERα, but not ERα36, imbues LSCC with enhanced aggression, a pattern which has previously only been observed in breast cancer. We make a case for using ERα as a tumorigenic modulator and pathogenic marker in LSCC on par with the use of ERα as a prognostic marker in breast cancer. SN - 1878-5867 UR - https://www.unboundmedicine.com/medline/citation/31539535/Estrogen_signaling_and_estrogen_receptors_as_prognostic_indicators_in_laryngeal_cancer L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-128X(19)30188-6 DB - PRIME DP - Unbound Medicine ER -