Tags

Type your tag names separated by a space and hit enter

Alcohol or Gut Microbiota: Who Is the Guilty?
Int J Mol Sci 2019; 20(18)IJ

Abstract

Alcoholic liver disease (ALD), a disorder caused by excessive alcohol intake represents a global health care burden. ALD encompasses a broad spectrum of hepatic injuries including asymptomatic steatosis, alcoholic steatohepatitis (ASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The susceptibility of alcoholic patients to develop ALD is highly variable and its progression to more advanced stages is strongly influenced by several hits (i.e., amount and duration of alcohol abuse). Among them, the intestinal microbiota and its metabolites have been recently identified as paramount in ALD pathophysiology. Ethanol abuse triggers qualitative and quantitative modifications in intestinal flora taxonomic composition, mucosal inflammation, and intestinal barrier derangement. Intestinal hypermeability results in the translocation of viable pathogenic bacteria, Gram-negative microbial products, and pro-inflammatory luminal metabolites into the bloodstream, further corroborating the alcohol-induced liver damage. Thus, the premise of this review is to discuss the beneficial effect of gut microbiota modulation as a novel therapeutic approach in ALD management.

Authors+Show Affiliations

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy. maricameroni11@gmail.com. General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. maricameroni11@gmail.com.General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. longo.miriam92@gmail.com.General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. paola.dongiovanni@policlinico.mi.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31540133

Citation

Meroni, Marica, et al. "Alcohol or Gut Microbiota: Who Is the Guilty?" International Journal of Molecular Sciences, vol. 20, no. 18, 2019.
Meroni M, Longo M, Dongiovanni P. Alcohol or Gut Microbiota: Who Is the Guilty? Int J Mol Sci. 2019;20(18).
Meroni, M., Longo, M., & Dongiovanni, P. (2019). Alcohol or Gut Microbiota: Who Is the Guilty? International Journal of Molecular Sciences, 20(18), doi:10.3390/ijms20184568.
Meroni M, Longo M, Dongiovanni P. Alcohol or Gut Microbiota: Who Is the Guilty. Int J Mol Sci. 2019 Sep 14;20(18) PubMed PMID: 31540133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol or Gut Microbiota: Who Is the Guilty? AU - Meroni,Marica, AU - Longo,Miriam, AU - Dongiovanni,Paola, Y1 - 2019/09/14/ PY - 2019/08/21/received PY - 2019/09/11/revised PY - 2019/09/12/accepted PY - 2019/9/22/entrez PY - 2019/9/22/pubmed PY - 2019/9/22/medline KW - alcoholic liver disease KW - fecal microbiota transplantation KW - gut microbiota KW - gut-liver axis KW - intestinal permeability KW - leaky gut KW - target therapy KW - tight junctions JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 18 N2 - Alcoholic liver disease (ALD), a disorder caused by excessive alcohol intake represents a global health care burden. ALD encompasses a broad spectrum of hepatic injuries including asymptomatic steatosis, alcoholic steatohepatitis (ASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The susceptibility of alcoholic patients to develop ALD is highly variable and its progression to more advanced stages is strongly influenced by several hits (i.e., amount and duration of alcohol abuse). Among them, the intestinal microbiota and its metabolites have been recently identified as paramount in ALD pathophysiology. Ethanol abuse triggers qualitative and quantitative modifications in intestinal flora taxonomic composition, mucosal inflammation, and intestinal barrier derangement. Intestinal hypermeability results in the translocation of viable pathogenic bacteria, Gram-negative microbial products, and pro-inflammatory luminal metabolites into the bloodstream, further corroborating the alcohol-induced liver damage. Thus, the premise of this review is to discuss the beneficial effect of gut microbiota modulation as a novel therapeutic approach in ALD management. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/31540133/Alcohol_or_Gut_Microbiota:_Who_Is_the_Guilty L2 - http://www.mdpi.com/resolver?pii=ijms20184568 DB - PRIME DP - Unbound Medicine ER -