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Bilateral Thyroid Carcinosarcoma in a Cat.
J Comp Pathol 2019; 171:24-29JC

Abstract

A neutered female domestic shorthaired cat was presented for a rapidly growing left cervical mass and a 6-month history of primary hyperthyroidism. Cytological examination of the mass was consistent with a sarcoma. Due to poor clinical response the cat was humanely destroyed and a post-mortem examination was performed. This revealed a markedly enlarged, irregularly shaped left thyroid gland with signs of infiltration of the trachea. The contralateral (right) thyroid was also moderately enlarged and irregularly shaped. Histopathological examination of the cervical masses indicated bilateral thyroid carcinosarcomas, evidenced by positive immunohistochemical labelling for vimentin, pan-cytokeratin and thyroid transcription factor-1 of the appropriate cell populations. The cat also had a concurrent pulmonary adenocarcinoma (papillary-lepidic type), unrelated to the thyroid neoplasm. Thyroid carcinosarcoma is an uncommonly recorded canine and human neoplasm and this is the first case of this entity to be reported in a cat.

Authors+Show Affiliations

Department of Veterinary Pathology and Public Health, University of Liverpool, Chester High Road, Neston, UK.Small Animal Teaching Hospital, University of Liverpool, Chester High Road, Neston, UK.Small Animal Teaching Hospital, University of Liverpool, Chester High Road, Neston, UK.Small Animal Teaching Hospital, University of Liverpool, Chester High Road, Neston, UK.Department of Veterinary Pathology and Public Health, University of Liverpool, Chester High Road, Neston, UK. Electronic address: r.j.blundell@liverpool.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31540622

Citation

Rich, A F., et al. "Bilateral Thyroid Carcinosarcoma in a Cat." Journal of Comparative Pathology, vol. 171, 2019, pp. 24-29.
Rich AF, Piviani M, Swales H, et al. Bilateral Thyroid Carcinosarcoma in a Cat. J Comp Pathol. 2019;171:24-29.
Rich, A. F., Piviani, M., Swales, H., Finotello, R., & Blundell, R. (2019). Bilateral Thyroid Carcinosarcoma in a Cat. Journal of Comparative Pathology, 171, pp. 24-29. doi:10.1016/j.jcpa.2019.07.001.
Rich AF, et al. Bilateral Thyroid Carcinosarcoma in a Cat. J Comp Pathol. 2019;171:24-29. PubMed PMID: 31540622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bilateral Thyroid Carcinosarcoma in a Cat. AU - Rich,A F, AU - Piviani,M, AU - Swales,H, AU - Finotello,R, AU - Blundell,R, Y1 - 2019/08/06/ PY - 2019/04/08/received PY - 2019/06/07/revised PY - 2019/07/04/accepted PY - 2019/9/22/entrez KW - carcinosarcoma KW - cat KW - immunohistochemistry KW - thyroid gland SP - 24 EP - 29 JF - Journal of comparative pathology JO - J. Comp. Pathol. VL - 171 N2 - A neutered female domestic shorthaired cat was presented for a rapidly growing left cervical mass and a 6-month history of primary hyperthyroidism. Cytological examination of the mass was consistent with a sarcoma. Due to poor clinical response the cat was humanely destroyed and a post-mortem examination was performed. This revealed a markedly enlarged, irregularly shaped left thyroid gland with signs of infiltration of the trachea. The contralateral (right) thyroid was also moderately enlarged and irregularly shaped. Histopathological examination of the cervical masses indicated bilateral thyroid carcinosarcomas, evidenced by positive immunohistochemical labelling for vimentin, pan-cytokeratin and thyroid transcription factor-1 of the appropriate cell populations. The cat also had a concurrent pulmonary adenocarcinoma (papillary-lepidic type), unrelated to the thyroid neoplasm. Thyroid carcinosarcoma is an uncommonly recorded canine and human neoplasm and this is the first case of this entity to be reported in a cat. SN - 1532-3129 UR - https://www.unboundmedicine.com/medline/citation/31540622/Bilateral_Thyroid_Carcinosarcoma_in_a_Cat L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9975(19)30101-X DB - PRIME DP - Unbound Medicine ER -