Tags

Type your tag names separated by a space and hit enter

Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility.
Reprod Biomed Online. 2019 Nov; 39(5):785-794.RB

Abstract

RESEARCH QUESTION

Does systemic oxidative stress occur during the early follicular phase of the menstrual cycle in infertile women with minimal (stage I) or mild (stage II) endometriosis? Are serum oxidative stress markers during the early follicular phase of the menstrual cycle good predictors of successful gestation in these women who undergo ovarian stimulation for intracytoplasmic sperm injection (ICSI)?

MATERIALS AND METHODS

A pilot study (prospective case-control study) was conducted in a University Hospital. Serum samples were obtained during the early follicular phase of the natural cycle preceding ovarian stimulation for ICSI of infertile women (with and without stage I and II endometriosis, the latter having male factor infertility). Total hydroperoxides (FOX1), malondialdehyde, advanced oxidation protein products, reduced glutathione, superoxide dismutase, total antioxidant capacity (TAC), 8-hydroxy-2'-deoxyguanosine (8OHdG) and vitamin E were analysed in serum from 35 women with stage I or II endometriosis and 60 control women. The accuracy of oxidative stress markers for predicting clinical pregnancy and live births was determined by receiver operator characteristic curves.

RESULTS

Women with stage I and II endometriosis showed lower serum 8OHdG concentrations (16.02 ng/ml) compared with the control group (22.08 ng/ml). The best predictor for clinical pregnancy and live births was TAC, whereas FOX1 was the best predictor of clinical pregnancy in the control group.

CONCLUSIONS

Infertile women with stage I and II endometriosis present systemic oxidative stress during the early follicular phase of the menstrual cycle. Some oxidative stress markers were good predictors of clinical pregnancy and live births after ICSI. Serum TAC was predictive of clinical pregnancy and live births after ICSI in women with stage I or II endometriosis.

Authors+Show Affiliations

Human Reproduction Division, Department of Obstetrics and Gynecology, Faculty of Medicine of RibeirãoPreto, University of São Paulo, Ribeirão Preto SP 14048-900, Brazil.Human Reproduction Division, Department of Obstetrics and Gynecology, Faculty of Medicine of RibeirãoPreto, University of São Paulo, Ribeirão Preto SP 14048-900, Brazil.Human Reproduction Division, Department of Obstetrics and Gynecology, Faculty of Medicine of RibeirãoPreto, University of São Paulo, Ribeirão Preto SP 14048-900, Brazil.Human Reproduction Division, Department of Obstetrics and Gynecology, Faculty of Medicine of RibeirãoPreto, University of São Paulo, Ribeirão Preto SP 14048-900, Brazil.Nutrition and Metabolism Laboratory, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto SP 14048-900, Brazil.Human Reproduction Division, Department of Obstetrics and Gynecology, Faculty of Medicine of RibeirãoPreto, University of São Paulo, Ribeirão Preto SP 14048-900, Brazil; National Institute of Hormones and Women's Health CNPq, Brazil. Electronic address: pnavarro@fmrp.usp.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31540845

Citation

Ferreira, Elisa Melo, et al. "Systemic Oxidative Stress as a Possible Mechanism Underlying the Pathogenesis of Mild Endometriosis-related Infertility." Reproductive Biomedicine Online, vol. 39, no. 5, 2019, pp. 785-794.
Ferreira EM, Giorgi VSI, Rodrigues JK, et al. Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility. Reprod Biomed Online. 2019;39(5):785-794.
Ferreira, E. M., Giorgi, V. S. I., Rodrigues, J. K., de Andrade, A. Z., Junior, A. A. J., & Navarro, P. A. (2019). Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility. Reproductive Biomedicine Online, 39(5), 785-794. https://doi.org/10.1016/j.rbmo.2019.06.011
Ferreira EM, et al. Systemic Oxidative Stress as a Possible Mechanism Underlying the Pathogenesis of Mild Endometriosis-related Infertility. Reprod Biomed Online. 2019;39(5):785-794. PubMed PMID: 31540845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility. AU - Ferreira,Elisa Melo, AU - Giorgi,Vanessa Silvestre Innocenti, AU - Rodrigues,Jhenifer Kliemchen, AU - de Andrade,Aline Zyman, AU - Junior,Alceu Afonso Jordão, AU - Navarro,Paula Andrea, Y1 - 2019/06/26/ PY - 2019/01/15/received PY - 2019/05/30/revised PY - 2019/06/21/accepted PY - 2019/9/22/pubmed PY - 2019/9/22/medline PY - 2019/9/22/entrez KW - Endometriosis KW - Infertility KW - Live births KW - Oxidative stress KW - Serum markers SP - 785 EP - 794 JF - Reproductive biomedicine online JO - Reprod. Biomed. Online VL - 39 IS - 5 N2 - RESEARCH QUESTION: Does systemic oxidative stress occur during the early follicular phase of the menstrual cycle in infertile women with minimal (stage I) or mild (stage II) endometriosis? Are serum oxidative stress markers during the early follicular phase of the menstrual cycle good predictors of successful gestation in these women who undergo ovarian stimulation for intracytoplasmic sperm injection (ICSI)? MATERIALS AND METHODS: A pilot study (prospective case-control study) was conducted in a University Hospital. Serum samples were obtained during the early follicular phase of the natural cycle preceding ovarian stimulation for ICSI of infertile women (with and without stage I and II endometriosis, the latter having male factor infertility). Total hydroperoxides (FOX1), malondialdehyde, advanced oxidation protein products, reduced glutathione, superoxide dismutase, total antioxidant capacity (TAC), 8-hydroxy-2'-deoxyguanosine (8OHdG) and vitamin E were analysed in serum from 35 women with stage I or II endometriosis and 60 control women. The accuracy of oxidative stress markers for predicting clinical pregnancy and live births was determined by receiver operator characteristic curves. RESULTS: Women with stage I and II endometriosis showed lower serum 8OHdG concentrations (16.02 ng/ml) compared with the control group (22.08 ng/ml). The best predictor for clinical pregnancy and live births was TAC, whereas FOX1 was the best predictor of clinical pregnancy in the control group. CONCLUSIONS: Infertile women with stage I and II endometriosis present systemic oxidative stress during the early follicular phase of the menstrual cycle. Some oxidative stress markers were good predictors of clinical pregnancy and live births after ICSI. Serum TAC was predictive of clinical pregnancy and live births after ICSI in women with stage I or II endometriosis. SN - 1472-6491 UR - https://www.unboundmedicine.com/medline/citation/31540845/Systemic_oxidative_stress_as_a_possible_mechanism_underlying_the_pathogenesis_of_mild_endometriosis_related_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(19)30598-X DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.