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Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice.
Eur J Pharmacol 2019; 863:172666EJ

Abstract

Incidence and prevalence of cancer is an alarming situation globally. For the treatment of cancer many anticancer drugs have been developed but, unfortunately, their potential cardiotoxic side effects raised serious concerns about their use among clinicians. Cyclophosphamide is a potent anticancer and immunosuppressant drug but its use is limited due to cardiotoxic side effect. Thus, there is a need for the development of certain drug which can reduce cardiotoxicity and can be used as an adjuvant therapy in cancer patients. In this direction we, therefore planned to evaluate nerolidol (NER) for its cardioprotective potential against cyclophosphamide-induced cardiotoxicity in Swiss Albino mice. Animals were divided into 6 groups. Vehicle control; Cyclophosphamide (CP 200); NER 400 per se; NER 200 + CP 200; NER 400 + CP 200; and fenofibrate (FF 80) + CP 200. Dosing was done for 14 days along with a single dose of CP 200 on the 7th day. On 15th day animals were sacrificed and various biochemical parameters pertaining to oxidative stress, nitrative stress, inflammation, apoptosis and fibrosis were estimated in the blood and heart tissues. Histopathological analysis (H & E and Masson's trichrome staining); ultrastructural analysis (transmission electron microscopy) and immunohistochemical analysis were also performed along with mRNA expression and molecular docking to establish the cardioprotective potential of nerolidol. Nerolidol acted as a potent cardioprotective molecule and attenuated CP-induced cardiotoxicity.

Authors+Show Affiliations

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.Department of Biotechnology, Jamia Millia Islamia, New Delhi, 110025, India.Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.Department of Biotechnology, Jamia Millia Islamia, New Delhi, 110025, India.Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. Electronic address: sehaq@jamiahamdard.ac.in.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31541628

Citation

Iqubal, Ashif, et al. "Nerolidol Attenuates Cyclophosphamide-induced Cardiac Inflammation, Apoptosis and Fibrosis in Swiss Albino Mice." European Journal of Pharmacology, vol. 863, 2019, p. 172666.
Iqubal A, Sharma S, Ansari MA, et al. Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice. Eur J Pharmacol. 2019;863:172666.
Iqubal, A., Sharma, S., Ansari, M. A., Najmi, A. K., Syed, M. A., Ali, J., ... Haque, S. E. (2019). Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice. European Journal of Pharmacology, 863, p. 172666. doi:10.1016/j.ejphar.2019.172666.
Iqubal A, et al. Nerolidol Attenuates Cyclophosphamide-induced Cardiac Inflammation, Apoptosis and Fibrosis in Swiss Albino Mice. Eur J Pharmacol. 2019 Sep 18;863:172666. PubMed PMID: 31541628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice. AU - Iqubal,Ashif, AU - Sharma,Sumit, AU - Ansari,Mohd Asif, AU - Najmi,Abul Kalam, AU - Syed,Mansoor Ali, AU - Ali,Javed, AU - Alam,M Mumtaz, AU - Ahmad,Shaniya, AU - Haque,Syed Ehtaishamul, Y1 - 2019/09/18/ PY - 2019/05/13/received PY - 2019/09/06/revised PY - 2019/09/17/accepted PY - 2019/9/22/pubmed PY - 2019/9/22/medline PY - 2019/9/22/entrez KW - BNP KW - Cardioprotection KW - Cleaved caspase 3 KW - Molecular docking KW - Oxidative stress KW - p-NF-κB p65 SP - 172666 EP - 172666 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 863 N2 - Incidence and prevalence of cancer is an alarming situation globally. For the treatment of cancer many anticancer drugs have been developed but, unfortunately, their potential cardiotoxic side effects raised serious concerns about their use among clinicians. Cyclophosphamide is a potent anticancer and immunosuppressant drug but its use is limited due to cardiotoxic side effect. Thus, there is a need for the development of certain drug which can reduce cardiotoxicity and can be used as an adjuvant therapy in cancer patients. In this direction we, therefore planned to evaluate nerolidol (NER) for its cardioprotective potential against cyclophosphamide-induced cardiotoxicity in Swiss Albino mice. Animals were divided into 6 groups. Vehicle control; Cyclophosphamide (CP 200); NER 400 per se; NER 200 + CP 200; NER 400 + CP 200; and fenofibrate (FF 80) + CP 200. Dosing was done for 14 days along with a single dose of CP 200 on the 7th day. On 15th day animals were sacrificed and various biochemical parameters pertaining to oxidative stress, nitrative stress, inflammation, apoptosis and fibrosis were estimated in the blood and heart tissues. Histopathological analysis (H & E and Masson's trichrome staining); ultrastructural analysis (transmission electron microscopy) and immunohistochemical analysis were also performed along with mRNA expression and molecular docking to establish the cardioprotective potential of nerolidol. Nerolidol acted as a potent cardioprotective molecule and attenuated CP-induced cardiotoxicity. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/31541628/Nerolidol_attenuates_cyclophosphamide-induced_cardiac_inflammation,_apoptosis_and_fibrosis_in_Swiss_Albino_mice L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(19)30618-1 DB - PRIME DP - Unbound Medicine ER -