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Unraveling the steroid hormone response in male marathon runners: Correlation of running time with aldosterone and progesterone.
J Steroid Biochem Mol Biol 2019; 195:105473JS

Abstract

Marathon running is a physical and psychological stressor. We aimed to characterize the response of nine steroid hormones, which include estradiol, progesterone, testosterone, cortisol, aldosterone, 17-hydroxyprogesterone, cortisone, androstenedione, and dehydroepiandrosterone sulfate, to marathon running and their association with performance. Blood samples of sixty men (age: 49.3 ± 5.9 years) who participated in the Berlin marathon were collected within 3 days before, within 30 min and within 58 h after the end of the marathon. The nine steroid hormones in serum were quantified using liquid chromatography-tandem mass spectrometry. The responses of nine steroid hormones to marathon running were characterized. Aldosterone (fold change: 8.5), progesterone (fold change: 6.6), and cortisol (fold change: 3.7) showed significant increases within 30 min after the marathon (all p < 0.0001). Estradiol but not testosterone increased in the male runners. Marathon running time was significantly related to aldosterone increase (beta=-0.238, p = 0.008) and progesterone increase (beta=-0.192, p = 0.036) in addition to body mass index, self-reported training distance, and age. Serum progesterone correlated with aldosterone and cortisol (r = 0.81 and r = 0.92, respectively, p < 0.001). Progesterone, as a precursor hormone, is increased after the completion of marathon running in association with the increase of aldosterone and cortisol. These findings reveal a contribution of progesterone during the response to the psycho-physical stress of marathon running in males.

Authors+Show Affiliations

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Paul-List Strasse 13-15, 04103, Leipzig, Germany. Electronic address: yoonju.bae@medizin.uni-leipzig.de.Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Paul-List Strasse 13-15, 04103, Leipzig, Germany.Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Paul-List Strasse 13-15, 04103, Leipzig, Germany.Department of Cardiology, Universitätsklinikum Leipzig, Liebigstraβe20, 04103, Leipzig, Germany.Department for Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University, Homburg, Saar, Germany.Department of Neurology, Charité - Universitätsmedizin Berlin, Germany.Department of Neurology, JüdischesKrankenhaus Berlin, Germany.Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE) & German Center for Cardiovascular Diseases (DZHK), Partner Site, Berlin, Germany.Department of Neurology, UniversitätsklinikumWürzburg, Germany.Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Paul-List Strasse 13-15, 04103, Leipzig, Germany.Department of Cardiology, Universitätsklinikum Leipzig, Liebigstraβe20, 04103, Leipzig, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31541731

Citation

Bae, Yoon Ju, et al. "Unraveling the Steroid Hormone Response in Male Marathon Runners: Correlation of Running Time With Aldosterone and Progesterone." The Journal of Steroid Biochemistry and Molecular Biology, vol. 195, 2019, p. 105473.
Bae YJ, Kratzsch J, Zeidler R, et al. Unraveling the steroid hormone response in male marathon runners: Correlation of running time with aldosterone and progesterone. J Steroid Biochem Mol Biol. 2019;195:105473.
Bae, Y. J., Kratzsch, J., Zeidler, R., Fikenzer, S., Werner, C., Herm, J., ... Laufs, U. (2019). Unraveling the steroid hormone response in male marathon runners: Correlation of running time with aldosterone and progesterone. The Journal of Steroid Biochemistry and Molecular Biology, 195, p. 105473. doi:10.1016/j.jsbmb.2019.105473.
Bae YJ, et al. Unraveling the Steroid Hormone Response in Male Marathon Runners: Correlation of Running Time With Aldosterone and Progesterone. J Steroid Biochem Mol Biol. 2019 Sep 18;195:105473. PubMed PMID: 31541731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unraveling the steroid hormone response in male marathon runners: Correlation of running time with aldosterone and progesterone. AU - Bae,Yoon Ju, AU - Kratzsch,Juergen, AU - Zeidler,Robert, AU - Fikenzer,Sven, AU - Werner,Christian, AU - Herm,Juliane, AU - Jungehülsing,Gerhard Jan, AU - Endres,Matthias, AU - Haeusler,Karl Georg, AU - Thiery,Joachim, AU - Laufs,Ulrich, Y1 - 2019/09/18/ PY - 2019/05/28/received PY - 2019/09/13/revised PY - 2019/09/17/accepted PY - 2019/9/22/pubmed PY - 2019/9/22/medline PY - 2019/9/22/entrez KW - Aldosterone KW - Male KW - Marathon KW - Progesterone KW - Steroid KW - Stress SP - 105473 EP - 105473 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 195 N2 - Marathon running is a physical and psychological stressor. We aimed to characterize the response of nine steroid hormones, which include estradiol, progesterone, testosterone, cortisol, aldosterone, 17-hydroxyprogesterone, cortisone, androstenedione, and dehydroepiandrosterone sulfate, to marathon running and their association with performance. Blood samples of sixty men (age: 49.3 ± 5.9 years) who participated in the Berlin marathon were collected within 3 days before, within 30 min and within 58 h after the end of the marathon. The nine steroid hormones in serum were quantified using liquid chromatography-tandem mass spectrometry. The responses of nine steroid hormones to marathon running were characterized. Aldosterone (fold change: 8.5), progesterone (fold change: 6.6), and cortisol (fold change: 3.7) showed significant increases within 30 min after the marathon (all p < 0.0001). Estradiol but not testosterone increased in the male runners. Marathon running time was significantly related to aldosterone increase (beta=-0.238, p = 0.008) and progesterone increase (beta=-0.192, p = 0.036) in addition to body mass index, self-reported training distance, and age. Serum progesterone correlated with aldosterone and cortisol (r = 0.81 and r = 0.92, respectively, p < 0.001). Progesterone, as a precursor hormone, is increased after the completion of marathon running in association with the increase of aldosterone and cortisol. These findings reveal a contribution of progesterone during the response to the psycho-physical stress of marathon running in males. SN - 1879-1220 UR - https://www.unboundmedicine.com/medline/citation/31541731/Unraveling_the_steroid_hormone_response_in_male_marathon_runners:_correlation_of_running_time_with_aldosterone_and_progesterone L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(19)30302-4 DB - PRIME DP - Unbound Medicine ER -