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Immunity to influenza: Impact of obesity.
Obes Res Clin Pract. 2019 Sep - Oct; 13(5):419-429.OR

Abstract

Obesity is a health concern that is recognized as a critical factor for vulnerability to influenza A/pdmH1N1 virus infection, with epidemiological and clinical impacts. In humans, obesity induces disturbances in inflammatory and immune responses to the influenza virus and in some cases, this leads to severe complications, with fatal outcomes. Obesity impairs immunity by altering the response of cytokines, resulting in a decrease in the cytotoxic cell response of immunocompetent cells which have a key anti-viral role. Additionally, obesity seems to disturb the balance of endocrine hormones, such as leptin, that affect the interplay between metabolic and immune systems. This contribution focuses on reviewing the current epidemiologic data for the immune response to immunity in obese humans and animal models. In doing so, we aim to provide potential mechanisms to enhance immunity to influenza A/pdmH1N1 virus infection and protective factors in obese people.

Authors+Show Affiliations

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, CP 11340, CDMX, Mexico.Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, CP 11340, CDMX, Mexico.Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco. Calzada del Hueso No. 1100, CP 04960, CDMX, Mexico.Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, CP 11340, CDMX, Mexico. Electronic address: sandii38@yahoo.com.mx.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

31542241

Citation

Rojas-Osornio, Sandra Angélica, et al. "Immunity to Influenza: Impact of Obesity." Obesity Research & Clinical Practice, vol. 13, no. 5, 2019, pp. 419-429.
Rojas-Osornio SA, Cruz-Hernández TR, Drago-Serrano ME, et al. Immunity to influenza: Impact of obesity. Obes Res Clin Pract. 2019;13(5):419-429.
Rojas-Osornio, S. A., Cruz-Hernández, T. R., Drago-Serrano, M. E., & Campos-Rodríguez, R. (2019). Immunity to influenza: Impact of obesity. Obesity Research & Clinical Practice, 13(5), 419-429. https://doi.org/10.1016/j.orcp.2019.05.003
Rojas-Osornio SA, et al. Immunity to Influenza: Impact of Obesity. Obes Res Clin Pract. 2019 Sep - Oct;13(5):419-429. PubMed PMID: 31542241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunity to influenza: Impact of obesity. AU - Rojas-Osornio,Sandra Angélica, AU - Cruz-Hernández,Teresita Rocío, AU - Drago-Serrano,Maria Elisa, AU - Campos-Rodríguez,Rafael, Y1 - 2019/09/19/ PY - 2018/10/19/received PY - 2019/05/14/revised PY - 2019/05/19/accepted PY - 2019/9/23/pubmed PY - 2020/7/28/medline PY - 2019/9/23/entrez KW - Influenza A/pdmH1N1 virus KW - Leptin KW - Obesity KW - Vaccine SP - 419 EP - 429 JF - Obesity research & clinical practice JO - Obes Res Clin Pract VL - 13 IS - 5 N2 - Obesity is a health concern that is recognized as a critical factor for vulnerability to influenza A/pdmH1N1 virus infection, with epidemiological and clinical impacts. In humans, obesity induces disturbances in inflammatory and immune responses to the influenza virus and in some cases, this leads to severe complications, with fatal outcomes. Obesity impairs immunity by altering the response of cytokines, resulting in a decrease in the cytotoxic cell response of immunocompetent cells which have a key anti-viral role. Additionally, obesity seems to disturb the balance of endocrine hormones, such as leptin, that affect the interplay between metabolic and immune systems. This contribution focuses on reviewing the current epidemiologic data for the immune response to immunity in obese humans and animal models. In doing so, we aim to provide potential mechanisms to enhance immunity to influenza A/pdmH1N1 virus infection and protective factors in obese people. SN - 1871-403X UR - https://www.unboundmedicine.com/medline/citation/31542241/Immunity_to_influenza:_Impact_of_obesity_ DB - PRIME DP - Unbound Medicine ER -