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[Effect on follicular development and pregnancy outcome treated with acupuncture and moxibustion therapy of Tiaochongren Gushenyuan in patients with luteal phase defect].
Zhongguo Zhen Jiu. 2019 Sep 12; 39(9):927-31.ZZ

Abstract

OBJECTIVE

To observe the effect of acupuncture and moxibustion therapy of Tiaochongren Gushenyuan on ovulation and embryo implantation in luteal phase defect patients with spleen-kidney yang deficiency.

METHODS

A total of 80 patients were randomly divided into an observation group and a control group, 40 cases in each one.In the observation group,acupuncture was applied at Shenting (GV 24), Shenque (CV 8), Guanyuan (CV 4), Qixue (KI 13), Lieque (LU 7), Gongsun (SP 4), Taixi (KI 3), Zusanli (ST 36) and Taichong (LR 3). And moxibustion was given at Taixi (KI 3) using moxibustion box during follicular phase, the stimulation of Taichong (LR 3) was strengthened during ovulatory phase, moxibustion was adopted at Shenque (CV 8) to Guanyuan (CV 4), Zusanli (ST 36) and Taixi (KI 3) during luteal phase. In the control group, acupuncture was applied at Guanyuan (CV 4), Dahe (KI 12), Sanyinjiao (SP 6), Ciliao (BL 32), Zhibian (BL 54) and Shenque (CV 8). Moxibustion was given at Sanyinjiao (SP 6) using moxibustion box during follicular phase, and moxibustion was adopted at Shenque (CV 8) to Guanyuan (CV 4) during luteal phase. The treatment were given every Monday, Wednesday and Friday, and the treatment were stoped during menstrual period in the two groups. Totally 3 menstrual cycle treatment were required, and 3 menstrual cycles were followed up. The pregnancy rate was observed after treatment, the ovulation rate, maximum folliclular diameter and difference of maximum folliclular diameters in ovulatory phase, serum progesterone (P) and basal body temperature (BBT) were compared before and after treatment in the two groups.

RESULTS

In the observation group, 6 cases of successful pregnancy during treatment,10 cases in follow-up, the clinical pregnancy rate was 40.0% (16/40). In the control group, 1 case of successful pregnancy during treatment, 5 cases in follow-up, the clinical pregnancy rate was 15.0% (6/40). The clinical pregnancy rate in the observation group was higher than the control group (P<0.05). The ovulation rate after treatment in the observation group was 90.0% (36/40), and the control group was 70.0% (28/40), compared before treatment, the ovulation rates were increased after treatment in the two groups (P<0.05). The observation group was higher than the control group, but there was no significant difference between the two groups (P>0.05). Compared before treatment, the maximum folliclular diameter and difference of maximum folliclular diameters in ovulatory phase, serum P after treatment were improved in the two groups (P<0.05), and the improvements of the observation group were significant compared with the control group (P<0.05). The BBT after treatment were superior to before treatment in the two groups (P<0.05). After treatment, the normal BBT in the observation group was 33 cases, while the control group was 22 cases (P<0.05).

CONCLUSION

Acupuncture and moxibustion therapy of Tiaochongren Gushenyuan can promote folliclar development, improve dominant follicle morphology, increase the level of serum P. The therapeutic effect is superior to routine acupuncture in increasing ovulation rate and improving pregnancy outcome.

Authors+Show Affiliations

Center for Disease Prevention, Affiliated Hospital of Chengdu University of TCM, Chengdu 610072, Sichun Province, China.Center for Disease Prevention, Affiliated Hospital of Chengdu University of TCM, Chengdu 610072, Sichun Province, China.Chengdu University of TCM.Chengdu University of TCM.Center for Disease Prevention, Affiliated Hospital of Chengdu University of TCM, Chengdu 610072, Sichun Province, China.Center for Disease Prevention, Affiliated Hospital of Chengdu University of TCM, Chengdu 610072, Sichun Province, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

31544378

Citation

Yang, Li-Jie, et al. "[Effect On Follicular Development and Pregnancy Outcome Treated With Acupuncture and Moxibustion Therapy of Tiaochongren Gushenyuan in Patients With Luteal Phase Defect]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 39, no. 9, 2019, pp. 927-31.
Yang LJ, Wu J, Yang L, et al. [Effect on follicular development and pregnancy outcome treated with acupuncture and moxibustion therapy of Tiaochongren Gushenyuan in patients with luteal phase defect]. Zhongguo Zhen Jiu. 2019;39(9):927-31.
Yang, L. J., Wu, J., Yang, L., Zhou, T., Li, H. R., & Miao, R. Q. (2019). [Effect on follicular development and pregnancy outcome treated with acupuncture and moxibustion therapy of Tiaochongren Gushenyuan in patients with luteal phase defect]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 39(9), 927-31. https://doi.org/10.13703/j.0255-2930.2019.09.004
Yang LJ, et al. [Effect On Follicular Development and Pregnancy Outcome Treated With Acupuncture and Moxibustion Therapy of Tiaochongren Gushenyuan in Patients With Luteal Phase Defect]. Zhongguo Zhen Jiu. 2019 Sep 12;39(9):927-31. PubMed PMID: 31544378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect on follicular development and pregnancy outcome treated with acupuncture and moxibustion therapy of Tiaochongren Gushenyuan in patients with luteal phase defect]. AU - Yang,Li-Jie, AU - Wu,Jie, AU - Yang,Lin, AU - Zhou,Te, AU - Li,Hong-Ru, AU - Miao,Run-Qing, PY - 2019/9/24/entrez PY - 2019/9/24/pubmed PY - 2019/11/8/medline KW - acupuncture and moxibustion therapy of Tiaochongren Gushenyuan KW - follicular development KW - luteal phase defect KW - pregnancy outcome SP - 927 EP - 31 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 39 IS - 9 N2 - OBJECTIVE: To observe the effect of acupuncture and moxibustion therapy of Tiaochongren Gushenyuan on ovulation and embryo implantation in luteal phase defect patients with spleen-kidney yang deficiency. METHODS: A total of 80 patients were randomly divided into an observation group and a control group, 40 cases in each one.In the observation group,acupuncture was applied at Shenting (GV 24), Shenque (CV 8), Guanyuan (CV 4), Qixue (KI 13), Lieque (LU 7), Gongsun (SP 4), Taixi (KI 3), Zusanli (ST 36) and Taichong (LR 3). And moxibustion was given at Taixi (KI 3) using moxibustion box during follicular phase, the stimulation of Taichong (LR 3) was strengthened during ovulatory phase, moxibustion was adopted at Shenque (CV 8) to Guanyuan (CV 4), Zusanli (ST 36) and Taixi (KI 3) during luteal phase. In the control group, acupuncture was applied at Guanyuan (CV 4), Dahe (KI 12), Sanyinjiao (SP 6), Ciliao (BL 32), Zhibian (BL 54) and Shenque (CV 8). Moxibustion was given at Sanyinjiao (SP 6) using moxibustion box during follicular phase, and moxibustion was adopted at Shenque (CV 8) to Guanyuan (CV 4) during luteal phase. The treatment were given every Monday, Wednesday and Friday, and the treatment were stoped during menstrual period in the two groups. Totally 3 menstrual cycle treatment were required, and 3 menstrual cycles were followed up. The pregnancy rate was observed after treatment, the ovulation rate, maximum folliclular diameter and difference of maximum folliclular diameters in ovulatory phase, serum progesterone (P) and basal body temperature (BBT) were compared before and after treatment in the two groups. RESULTS: In the observation group, 6 cases of successful pregnancy during treatment,10 cases in follow-up, the clinical pregnancy rate was 40.0% (16/40). In the control group, 1 case of successful pregnancy during treatment, 5 cases in follow-up, the clinical pregnancy rate was 15.0% (6/40). The clinical pregnancy rate in the observation group was higher than the control group (P<0.05). The ovulation rate after treatment in the observation group was 90.0% (36/40), and the control group was 70.0% (28/40), compared before treatment, the ovulation rates were increased after treatment in the two groups (P<0.05). The observation group was higher than the control group, but there was no significant difference between the two groups (P>0.05). Compared before treatment, the maximum folliclular diameter and difference of maximum folliclular diameters in ovulatory phase, serum P after treatment were improved in the two groups (P<0.05), and the improvements of the observation group were significant compared with the control group (P<0.05). The BBT after treatment were superior to before treatment in the two groups (P<0.05). After treatment, the normal BBT in the observation group was 33 cases, while the control group was 22 cases (P<0.05). CONCLUSION: Acupuncture and moxibustion therapy of Tiaochongren Gushenyuan can promote folliclar development, improve dominant follicle morphology, increase the level of serum P. The therapeutic effect is superior to routine acupuncture in increasing ovulation rate and improving pregnancy outcome. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/31544378/[Effect_on_follicular_development_and_pregnancy_outcome_treated_with_acupuncture_and_moxibustion_therapy_of_Tiaochongren_Gushenyuan_in_patients_with_luteal_phase_defect]_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -