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The diagnostic role of the β-hCG discriminatory zone combined with the endometrial pattern for ectopic pregnancy in Chinese women.
Sci Rep 2019; 9(1):13781SR

Abstract

Previous studies have regarded the discriminatory serum β-hCG zone (DSZ) as a valuable tool for the diagnosis of ectopic pregnancy (EP). However, the wide range of the DSZ makes achieving a clinical diagnosis of EP difficult, and these reports do not indicate whether the DSZ is suitable for an EP diagnosis in Chinese women. Several studies have indicated that the endometrial pattern in patients with EPs is different from that in patients with intrauterine pregnancies (IUPs). The aims of this study were to define the DSZ cutoff value for Chinese women, test whether the endometrial pattern is a suitable predictor for EP, and assess the diagnostic value of these indicators. We enrolled participants with IUPs or EPs with abdominal pain and/or vaginal bleeding, and serum β-hCG level measurements and transvaginal ultrasound (TVS) were performed to assess the diagnostic value of the indicators for EP. The sensitivity and specificity for identifying an EP were improved by combining the DSZ, endometrial thickness and trilaminar pattern indexes. The results of this study might be helpful toward providing further options for the diagnosis of EP, especially for patients without hemoperitoneum or colporrhagia.

Authors+Show Affiliations

Department of Gynecology, Jinshan Hospital of Fudan University, 1508 Longhang Rd., Shanghai, 201508, China.Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Rd., Shanghai, 200030, China.Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Rd., Shanghai, 200030, China.Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Rd., Shanghai, 200030, China.Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Rd., Shanghai, 200030, China.Department of Ultrasound in Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Rd., Shanghai, 200030, China. yy_zhouyun@126.com.Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine, 910 Hengshan Rd., Shanghai, 200030, China. owangydong@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31551446

Citation

Lu, Qi, et al. "The Diagnostic Role of the β-hCG Discriminatory Zone Combined With the Endometrial Pattern for Ectopic Pregnancy in Chinese Women." Scientific Reports, vol. 9, no. 1, 2019, p. 13781.
Lu Q, Wang Y, Sun X, et al. The diagnostic role of the β-hCG discriminatory zone combined with the endometrial pattern for ectopic pregnancy in Chinese women. Sci Rep. 2019;9(1):13781.
Lu, Q., Wang, Y., Sun, X., Li, Y., Wang, J., Zhou, Y., & Wang, Y. (2019). The diagnostic role of the β-hCG discriminatory zone combined with the endometrial pattern for ectopic pregnancy in Chinese women. Scientific Reports, 9(1), p. 13781. doi:10.1038/s41598-019-50151-x.
Lu Q, et al. The Diagnostic Role of the β-hCG Discriminatory Zone Combined With the Endometrial Pattern for Ectopic Pregnancy in Chinese Women. Sci Rep. 2019 Sep 24;9(1):13781. PubMed PMID: 31551446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The diagnostic role of the β-hCG discriminatory zone combined with the endometrial pattern for ectopic pregnancy in Chinese women. AU - Lu,Qi, AU - Wang,Yiwei, AU - Sun,Xiao, AU - Li,Yuhong, AU - Wang,Jing, AU - Zhou,Yun, AU - Wang,Yudong, Y1 - 2019/09/24/ PY - 2019/04/10/received PY - 2019/09/06/accepted PY - 2019/9/26/entrez PY - 2019/9/26/pubmed PY - 2019/9/26/medline SP - 13781 EP - 13781 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - Previous studies have regarded the discriminatory serum β-hCG zone (DSZ) as a valuable tool for the diagnosis of ectopic pregnancy (EP). However, the wide range of the DSZ makes achieving a clinical diagnosis of EP difficult, and these reports do not indicate whether the DSZ is suitable for an EP diagnosis in Chinese women. Several studies have indicated that the endometrial pattern in patients with EPs is different from that in patients with intrauterine pregnancies (IUPs). The aims of this study were to define the DSZ cutoff value for Chinese women, test whether the endometrial pattern is a suitable predictor for EP, and assess the diagnostic value of these indicators. We enrolled participants with IUPs or EPs with abdominal pain and/or vaginal bleeding, and serum β-hCG level measurements and transvaginal ultrasound (TVS) were performed to assess the diagnostic value of the indicators for EP. The sensitivity and specificity for identifying an EP were improved by combining the DSZ, endometrial thickness and trilaminar pattern indexes. The results of this study might be helpful toward providing further options for the diagnosis of EP, especially for patients without hemoperitoneum or colporrhagia. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/31551446/The_diagnostic_role_of_the_β-hCG_discriminatory_zone_combined_with_the_endometrial_pattern_for_ectopic_pregnancy_in_Chinese_women L2 - http://dx.doi.org/10.1038/s41598-019-50151-x DB - PRIME DP - Unbound Medicine ER -