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Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases.
Front Immunol 2019; 10:2113FI

Abstract

The intestine has a major role in the digestion and absorption of nutrients, and gut barrier is the first defense line against harmful pathogens. Alteration of the intestinal barrier is associated with enhanced intestinal permeability and development of numerous pathological diseases including gastrointestinal and cardiometabolic diseases. Among the metabolites that play an important role within intestinal health, L Tryptophan (Trp) is one of the nine essential amino acids supplied by diet, whose metabolism appears as a key modulator of gut microbiota, with major impacts on physiological, and pathological pathways. Recently, emerging evidence showed that the Trp catabolism through one major enzyme indoleamine 2,3-dioxygenase 1 (IDO1) expressed by the host affects Trp metabolism by gut microbiota to generate indole metabolites, thereby altering gut function and health in mice and humans. In this mini review, I summarize the most recent advances concerning the role of Trp metabolism in host-microbiota cross-talk in health, and metabolic diseases. This novel aspect of IDO1 function in intestine will better explain its complex roles in a broad range of disease states where the gut function affects local as well as systemic health, and will open new therapeutic strategies.

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale (INSERM), Unit 970, Paris Cardiovascular Research Center, and Université Paris-Descartes, Paris, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31552046

Citation

Taleb, Soraya. "Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases." Frontiers in Immunology, vol. 10, 2019, p. 2113.
Taleb S. Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases. Front Immunol. 2019;10:2113.
Taleb, S. (2019). Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases. Frontiers in Immunology, 10, p. 2113. doi:10.3389/fimmu.2019.02113.
Taleb S. Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases. Front Immunol. 2019;10:2113. PubMed PMID: 31552046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tryptophan Dietary Impacts Gut Barrier and Metabolic Diseases. A1 - Taleb,Soraya, Y1 - 2019/09/10/ PY - 2019/04/25/received PY - 2019/08/21/accepted PY - 2019/9/26/entrez PY - 2019/9/26/pubmed PY - 2019/9/26/medline KW - 3-dioxygenase KW - cardiovascular disease and cardiometabolic diseases KW - gut microbiota KW - indoleamine 2 KW - metabolic syndrome KW - tryptophan SP - 2113 EP - 2113 JF - Frontiers in immunology JO - Front Immunol VL - 10 N2 - The intestine has a major role in the digestion and absorption of nutrients, and gut barrier is the first defense line against harmful pathogens. Alteration of the intestinal barrier is associated with enhanced intestinal permeability and development of numerous pathological diseases including gastrointestinal and cardiometabolic diseases. Among the metabolites that play an important role within intestinal health, L Tryptophan (Trp) is one of the nine essential amino acids supplied by diet, whose metabolism appears as a key modulator of gut microbiota, with major impacts on physiological, and pathological pathways. Recently, emerging evidence showed that the Trp catabolism through one major enzyme indoleamine 2,3-dioxygenase 1 (IDO1) expressed by the host affects Trp metabolism by gut microbiota to generate indole metabolites, thereby altering gut function and health in mice and humans. In this mini review, I summarize the most recent advances concerning the role of Trp metabolism in host-microbiota cross-talk in health, and metabolic diseases. This novel aspect of IDO1 function in intestine will better explain its complex roles in a broad range of disease states where the gut function affects local as well as systemic health, and will open new therapeutic strategies. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/31552046/Tryptophan_Dietary_Impacts_Gut_Barrier_and_Metabolic_Diseases L2 - https://doi.org/10.3389/fimmu.2019.02113 DB - PRIME DP - Unbound Medicine ER -
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