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Pulmonary involvement in primary Sjögren's syndrome, as measured by the ESSDAI.
Scand J Rheumatol. 2020 Jan; 49(1):38-46.SJ

Abstract

Objective:

Systemic features influence disease prognosis and choice of treatment in primary Sjögren's syndrome (pSS). Our aim was to investigate the prevalence of pulmonary involvement in pSS patients and to classify patients according to the pulmonary domain of the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI).

Methods:

This retrospective cohort study included consecutive pSS patients, fulfilling American-European Consensus Group/American College of Rheumatology classification criteria, who visited the Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, in 2015. Data on pulmonary complaints and pulmonary tests were obtained from electronic patient records. Pulmonary involvement was recorded if therapy was needed or follow-up was recommended, and when it was possibly or assumed to be related to pSS instead of coincidental factors.

Results:

Of the 262 included pSS patients, 88 (34%) had pulmonary complaints, mostly cough or dyspnoea on exertion. Pulmonary diagnostics were performed in 225 patients (86%). Pulmonary involvement was present and assumed to be related to pSS in 25 patients (10%) and possibly related to pSS in 14 (5%). Interstitial lung disease (ILD, n = 15), especially non-specific interstitial pneumonia (n = 7), was present most commonly. In total, 16 patients (6%) were scored as low (n = 4), moderate (n = 11), or high activity (n = 1) on the ESSDAI pulmonary domain.

Conclusion:

In this cross-sectional study in daily clinical practice, pulmonary involvement was present in 10-15% of pSS patients, of which ILD was most common. Of all pSS patients, 6% were scored as active on the pulmonary domain of the ESSDAI.

Authors+Show Affiliations

Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Department of Radiology, Medical Spectrum Twente, Enschede, The Netherlands.Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31556344

Citation

Heus, A, et al. "Pulmonary Involvement in Primary Sjögren's Syndrome, as Measured By the ESSDAI." Scandinavian Journal of Rheumatology, vol. 49, no. 1, 2020, pp. 38-46.
Heus A, Arends S, Van Nimwegen JF, et al. Pulmonary involvement in primary Sjögren's syndrome, as measured by the ESSDAI. Scand J Rheumatol. 2020;49(1):38-46.
Heus, A., Arends, S., Van Nimwegen, J. F., Stel, A. J., Nossent, G. D., & Bootsma, H. (2020). Pulmonary involvement in primary Sjögren's syndrome, as measured by the ESSDAI. Scandinavian Journal of Rheumatology, 49(1), 38-46. https://doi.org/10.1080/03009742.2019.1634221
Heus A, et al. Pulmonary Involvement in Primary Sjögren's Syndrome, as Measured By the ESSDAI. Scand J Rheumatol. 2020;49(1):38-46. PubMed PMID: 31556344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulmonary involvement in primary Sjögren's syndrome, as measured by the ESSDAI. AU - Heus,A, AU - Arends,S, AU - Van Nimwegen,J F, AU - Stel,A J, AU - Nossent,G D, AU - Bootsma,H, Y1 - 2019/09/26/ PY - 2019/9/27/pubmed PY - 2020/5/6/medline PY - 2019/9/27/entrez SP - 38 EP - 46 JF - Scandinavian journal of rheumatology JO - Scand J Rheumatol VL - 49 IS - 1 N2 - Objective: Systemic features influence disease prognosis and choice of treatment in primary Sjögren's syndrome (pSS). Our aim was to investigate the prevalence of pulmonary involvement in pSS patients and to classify patients according to the pulmonary domain of the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI).Methods: This retrospective cohort study included consecutive pSS patients, fulfilling American-European Consensus Group/American College of Rheumatology classification criteria, who visited the Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, in 2015. Data on pulmonary complaints and pulmonary tests were obtained from electronic patient records. Pulmonary involvement was recorded if therapy was needed or follow-up was recommended, and when it was possibly or assumed to be related to pSS instead of coincidental factors.Results: Of the 262 included pSS patients, 88 (34%) had pulmonary complaints, mostly cough or dyspnoea on exertion. Pulmonary diagnostics were performed in 225 patients (86%). Pulmonary involvement was present and assumed to be related to pSS in 25 patients (10%) and possibly related to pSS in 14 (5%). Interstitial lung disease (ILD, n = 15), especially non-specific interstitial pneumonia (n = 7), was present most commonly. In total, 16 patients (6%) were scored as low (n = 4), moderate (n = 11), or high activity (n = 1) on the ESSDAI pulmonary domain.Conclusion: In this cross-sectional study in daily clinical practice, pulmonary involvement was present in 10-15% of pSS patients, of which ILD was most common. Of all pSS patients, 6% were scored as active on the pulmonary domain of the ESSDAI. SN - 1502-7732 UR - https://www.unboundmedicine.com/medline/citation/31556344/Pulmonary_involvement_in_primary_Sj��gren's_syndrome_as_measured_by_the_ESSDAI_ L2 - https://www.tandfonline.com/doi/full/10.1080/03009742.2019.1634221 DB - PRIME DP - Unbound Medicine ER -