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Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update.
Polymers (Basel). 2019 Sep 25; 11(10)P

Abstract

The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxyl group lends itself to a variety of chemical derivatizations via simple reaction pathways which alter its physico-chemical properties with a possibility to generate an endless number of possible active macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature.

Authors+Show Affiliations

School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK. sadie.swainson@nottingham.ac.uk.School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK. i.d.styliari@herts.ac.uk.School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK. vincenzo.taresco@nottingham.ac.uk. School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK. vincenzo.taresco@nottingham.ac.uk.School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK. martin.garnett@nottingham.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31557875

Citation

Swainson, Sadie M E., et al. "Poly (glycerol Adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: a Literature Update." Polymers, vol. 11, no. 10, 2019.
Swainson SME, Styliari ID, Taresco V, et al. Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. Polymers (Basel). 2019;11(10).
Swainson, S. M. E., Styliari, I. D., Taresco, V., & Garnett, M. C. (2019). Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. Polymers, 11(10). https://doi.org/10.3390/polym11101561
Swainson SME, et al. Poly (glycerol Adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: a Literature Update. Polymers (Basel). 2019 Sep 25;11(10) PubMed PMID: 31557875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update. AU - Swainson,Sadie M E, AU - Styliari,Ioanna D, AU - Taresco,Vincenzo, AU - Garnett,Martin C, Y1 - 2019/09/25/ PY - 2019/07/29/received PY - 2019/09/09/revised PY - 2019/09/20/accepted PY - 2019/9/28/entrez PY - 2019/9/29/pubmed PY - 2019/9/29/medline KW - biodegradable KW - functionalization KW - lipase KW - poly(glycerol adipate) KW - polymeric platforms JF - Polymers JO - Polymers (Basel) VL - 11 IS - 10 N2 - The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug delivery. The step-growth polymerization pathway catalyzed by lipase generates a highly functionalizable platform while avoiding tedious steps of protection and deprotection. Synthesis requires only minor purification steps and uses cheap and readily available reagents. The final polymeric material is biodegradable, biocompatible and intrinsically amphiphilic, with a good propensity to self-assemble into nanoparticles (NPs). The free hydroxyl group lends itself to a variety of chemical derivatizations via simple reaction pathways which alter its physico-chemical properties with a possibility to generate an endless number of possible active macromolecules. The present work aims to summarize the available literature about PGA synthesis, architecture alterations, chemical modifications and its application in drug and gene delivery as a versatile carrier. Following on from this, the evolution of the concept of enzymatically-degradable PGA-drug conjugation has been explored, reporting recent examples in the literature. SN - 2073-4360 UR - https://www.unboundmedicine.com/medline/citation/31557875/Poly__glycerol_adipate___PGA__an_Enzymatically_Synthesized_Functionalizable_Polyester_and_Versatile_Drug_Delivery_Carrier:_A_Literature_Update_ L2 - http://www.mdpi.com/resolver?pii=polym11101561 DB - PRIME DP - Unbound Medicine ER -
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