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Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features.
Ocul Oncol Pathol. 2019 Aug; 5(5):312-318.OO

Abstract

Large cell acanthoma (LCA) was first described as a lesion on sun-exposed skin. All LCAs feature keratinocytes twice the size of normal cells (cytomegaly). Although infrequently diagnosed in the skin, it has been even more rarely described by ophthalmic pathologists in the eyelid skin and the conjunctiva. This report describes the third case of a conjunctival epithelial LCA, with the first published clinical photograph highlighting its leukoplakic and well-circumscribed character, as well as the most thorough analysis of the immunohistochemical features of this lesion. It is contrasted with squamous dysplasias and papillomas of the conjunctiva. A review of previous conjunctival LCA lesions discloses frequent recurrences after initial surgery and the remote but real potential for squamous dysplastic transformation. Immunohistochemical stains for certain cytokeratins, p53, and Ki-67 (proliferation index) will in the future be particularly helpful in establishing an early and accurate diagnosis of conjunctival LCA.

Authors+Show Affiliations

David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston, Massachusetts, USA.David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston, Massachusetts, USA.David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston, Massachusetts, USA.Eye Health Services, Quincy, Massachusetts, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31559241

Citation

Jakobiec, Frederick A., et al. "Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features." Ocular Oncology and Pathology, vol. 5, no. 5, 2019, pp. 312-318.
Jakobiec FA, Cortes Barrantes P, Ma L, et al. Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. Ocul Oncol Pathol. 2019;5(5):312-318.
Jakobiec, F. A., Cortes Barrantes, P., Ma, L., & Mandeville, J. (2019). Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. Ocular Oncology and Pathology, 5(5), 312-318. https://doi.org/10.1159/000495250
Jakobiec FA, et al. Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. Ocul Oncol Pathol. 2019;5(5):312-318. PubMed PMID: 31559241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. AU - Jakobiec,Frederick A, AU - Cortes Barrantes,Paula, AU - Ma,Lina, AU - Mandeville,John, Y1 - 2019/01/16/ PY - 2018/10/08/received PY - 2018/11/08/revised PY - 2019/9/28/entrez PY - 2019/9/29/pubmed PY - 2019/9/29/medline KW - Conjunctiva KW - Cytokeratins KW - Ki-67 KW - Large cell acanthoma KW - Mucous membranes KW - Skin KW - p53 SP - 312 EP - 318 JF - Ocular oncology and pathology JO - Ocul Oncol Pathol VL - 5 IS - 5 N2 - Large cell acanthoma (LCA) was first described as a lesion on sun-exposed skin. All LCAs feature keratinocytes twice the size of normal cells (cytomegaly). Although infrequently diagnosed in the skin, it has been even more rarely described by ophthalmic pathologists in the eyelid skin and the conjunctiva. This report describes the third case of a conjunctival epithelial LCA, with the first published clinical photograph highlighting its leukoplakic and well-circumscribed character, as well as the most thorough analysis of the immunohistochemical features of this lesion. It is contrasted with squamous dysplasias and papillomas of the conjunctiva. A review of previous conjunctival LCA lesions discloses frequent recurrences after initial surgery and the remote but real potential for squamous dysplastic transformation. Immunohistochemical stains for certain cytokeratins, p53, and Ki-67 (proliferation index) will in the future be particularly helpful in establishing an early and accurate diagnosis of conjunctival LCA. SN - 2296-4681 UR - https://www.unboundmedicine.com/medline/citation/31559241/Large_Cell_Acanthoma_of_the_Conjunctiva:_Clinicopathologic_and_Immunohistochemical_Features L2 - https://www.karger.com?DOI=10.1159/000495250 DB - PRIME DP - Unbound Medicine ER -
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