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Aspects of Prostaglandin Glycerol Ester Biology.
Adv Exp Med Biol. 2019; 1161:77-88.AE

Abstract

The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins. However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG). The products of 2-AG oxygenation, prostaglandin glycerol esters (PG-Gs), are analogous to canonical prostaglandins. This chapter reviews the literature detailing the production, metabolism, and bioactivity of these compounds, as well as their detection in intact animals.

Authors+Show Affiliations

A. B. Hancock Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.A. B. Hancock Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.A. B. Hancock Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.Department of Psychiatry and Behavioral Sciences, Department of Molecular Physiology & Biophysics, and the Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.A. B. Hancock Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA. larry.marnett@Vanderbilt.Edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31562623

Citation

Kingsley, Philip J., et al. "Aspects of Prostaglandin Glycerol Ester Biology." Advances in Experimental Medicine and Biology, vol. 1161, 2019, pp. 77-88.
Kingsley PJ, Rouzer CA, Morgan AJ, et al. Aspects of Prostaglandin Glycerol Ester Biology. Adv Exp Med Biol. 2019;1161:77-88.
Kingsley, P. J., Rouzer, C. A., Morgan, A. J., Patel, S., & Marnett, L. J. (2019). Aspects of Prostaglandin Glycerol Ester Biology. Advances in Experimental Medicine and Biology, 1161, 77-88. https://doi.org/10.1007/978-3-030-21735-8_8
Kingsley PJ, et al. Aspects of Prostaglandin Glycerol Ester Biology. Adv Exp Med Biol. 2019;1161:77-88. PubMed PMID: 31562623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aspects of Prostaglandin Glycerol Ester Biology. AU - Kingsley,Philip J, AU - Rouzer,Carol A, AU - Morgan,Amanda J, AU - Patel,Sachin, AU - Marnett,Lawrence J, PY - 2019/9/29/entrez PY - 2019/9/29/pubmed PY - 2019/10/3/medline KW - 2-Arachidonoyl glycerol KW - Anandamide KW - COX-2 KW - Cannabinoid KW - Cyclooxygenase KW - Endocannabinoid KW - Inflammation KW - Prostaglandin KW - Prostaglandin glyceryl ester KW - Transgenic mouse SP - 77 EP - 88 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 1161 N2 - The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O2 into arachidonic acid (AA), resulting in an array of bioactive prostaglandins. However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG). The products of 2-AG oxygenation, prostaglandin glycerol esters (PG-Gs), are analogous to canonical prostaglandins. This chapter reviews the literature detailing the production, metabolism, and bioactivity of these compounds, as well as their detection in intact animals. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/31562623/Aspects_of_Prostaglandin_Glycerol_Ester_Biology_ L2 - https://dx.doi.org/10.1007/978-3-030-21735-8_8 DB - PRIME DP - Unbound Medicine ER -