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Urinary bisphenol A and thyroid function by BMI in the Korean National Environmental Health Survey (KoNEHS) 2012-2014.
Chemosphere. 2020 Feb; 240:124918.C

Abstract

Bisphenol A (BPA) is one of the largest amounts of chemicals in daily life and source of polycarbonate plastics, epoxy resins, medical equipment, plastic consumer products. Recent studies reported that the effects of BPA on human health in the thyroid hormone. Therefore, this study aimed to indicate the association between urinary BPA concentration and thyroid function in total triiodothyronine (T3), thyroxine (T4), thyroidal stimulating hormone (TSH) and stratified the population by body mass index (BMI). This study was performed on 6478 adults aged 19 years and older based on the Second Korean National Environmental Health Survey (KoNEHS, 2012-2014). We measured BPA in urine and total T3, T4 and TSH in serum from the 2nd KoNEHS study. The multiple regression analysis was performed to assess the association of urinary BPA concentrations with thyroid hormone after BMI stratification. Urinary BPA associated with thyroid hormone. Especially, BPA is related to T3 (-0.627) in all group, and T4 (-0.060, -0.098) in all group and the group of BMI 25.0kg/m2 or more negatively. When stratified by BPA, T3 and T4 were significantly decreased with the high BPA exposure compared with the low BPA exposure for BMI more than 25.0kg/m2 (adjusted β = -3.402, 95% CI: 4.942, -1.862, adjusted β = -0.209, 95% CI: 0.328, -0.090). However, no obvious associations were found between BPA concentration and TSH. The results of urinary BPA decrease with T3 and T4 levels increase in the higher BMI group is a new finding which does not exist in recent studies of Korea.

Authors+Show Affiliations

Graduate School of Public Health, Yonsei University, 03722, Seoul, Republic of Korea.Department of Occupational and Environmental Medicine, Ewha Medical Research Center, College of Medicine, Ewha Womans University, 07804, Seoul, Republic of Korea.Carcinogenic Hazards Branch, Division of Cancer Prevention, National Cancer Control Institute, National Cancer Center, 10408, Gyeonggi, Goyang, Republic of Korea. Electronic address: kbm5369@ncc.re.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31563717

Citation

Kwon, Jeoung A., et al. "Urinary Bisphenol a and Thyroid Function By BMI in the Korean National Environmental Health Survey (KoNEHS) 2012-2014." Chemosphere, vol. 240, 2020, p. 124918.
Kwon JA, Shin B, Kim B. Urinary bisphenol A and thyroid function by BMI in the Korean National Environmental Health Survey (KoNEHS) 2012-2014. Chemosphere. 2020;240:124918.
Kwon, J. A., Shin, B., & Kim, B. (2020). Urinary bisphenol A and thyroid function by BMI in the Korean National Environmental Health Survey (KoNEHS) 2012-2014. Chemosphere, 240, 124918. https://doi.org/10.1016/j.chemosphere.2019.124918
Kwon JA, Shin B, Kim B. Urinary Bisphenol a and Thyroid Function By BMI in the Korean National Environmental Health Survey (KoNEHS) 2012-2014. Chemosphere. 2020;240:124918. PubMed PMID: 31563717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary bisphenol A and thyroid function by BMI in the Korean National Environmental Health Survey (KoNEHS) 2012-2014. AU - Kwon,Jeoung A, AU - Shin,Bohye, AU - Kim,Byungmi, Y1 - 2019/09/19/ PY - 2019/07/11/received PY - 2019/09/09/revised PY - 2019/09/19/accepted PY - 2019/9/30/pubmed PY - 2020/1/21/medline PY - 2019/9/30/entrez KW - BMI KW - BPA KW - T3 KW - T4 KW - TSH SP - 124918 EP - 124918 JF - Chemosphere JO - Chemosphere VL - 240 N2 - Bisphenol A (BPA) is one of the largest amounts of chemicals in daily life and source of polycarbonate plastics, epoxy resins, medical equipment, plastic consumer products. Recent studies reported that the effects of BPA on human health in the thyroid hormone. Therefore, this study aimed to indicate the association between urinary BPA concentration and thyroid function in total triiodothyronine (T3), thyroxine (T4), thyroidal stimulating hormone (TSH) and stratified the population by body mass index (BMI). This study was performed on 6478 adults aged 19 years and older based on the Second Korean National Environmental Health Survey (KoNEHS, 2012-2014). We measured BPA in urine and total T3, T4 and TSH in serum from the 2nd KoNEHS study. The multiple regression analysis was performed to assess the association of urinary BPA concentrations with thyroid hormone after BMI stratification. Urinary BPA associated with thyroid hormone. Especially, BPA is related to T3 (-0.627) in all group, and T4 (-0.060, -0.098) in all group and the group of BMI 25.0kg/m2 or more negatively. When stratified by BPA, T3 and T4 were significantly decreased with the high BPA exposure compared with the low BPA exposure for BMI more than 25.0kg/m2 (adjusted β = -3.402, 95% CI: 4.942, -1.862, adjusted β = -0.209, 95% CI: 0.328, -0.090). However, no obvious associations were found between BPA concentration and TSH. The results of urinary BPA decrease with T3 and T4 levels increase in the higher BMI group is a new finding which does not exist in recent studies of Korea. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/31563717/Urinary_bisphenol_A_and_thyroid_function_by_BMI_in_the_Korean_National_Environmental_Health_Survey__KoNEHS__2012_2014_ DB - PRIME DP - Unbound Medicine ER -