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Relationship between corneal deformation amplitude and optic nerve head structure in primary open-angle glaucoma.
Medicine (Baltimore) 2019; 98(38):e17223M

Abstract

The purpose of the study was to investigate the relationship between corneal deformation amplitude (DA), which is the amount of corneal displacement at highest degree of concavity measured by Corvis Scheimpflug Technology (ST), and various optic nerve head parameters in patients with primary open-angle glaucoma (POAG).Fifty-eight POAG patients were included in this observational study. For each patient, DA with Corvis ST, color optic disc photography, and optic nerve head imaging by enhanced depth imaging with a Heidelberg spectralis optical coherence tomography (OCT), Cirrus OCT, and Heidelberg retina tomograph (HRT) were obtained. Pearson correlation was used to analyze the relationship between DA and optic nerve head parameters before and after adjusting for age, intraocular pressure, central corneal thickness, and axial length.Corneal DA was negatively associated with lamina cribrosa (LC) depth (r = -0.390, P = .003) after adjusting for confounders. It showed positive relationship with parapapillary atrophy (PPA) area (r = 0.321, P = .046). In addition, the corneal DA was negatively correlated with cup volume (r = -0.351, P = .017) and mean cup depth (r = -0.409, P = .005) measured by HRT.Corneal DA is related with optic nerve head parameters in patients with POAG. Patients with lower corneal DA showed greater LC depth, greater cup area, deeper cup, and smaller PPA than those with higher corneal DA.

Authors+Show Affiliations

Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine.Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31567980

Citation

Jung, Younhea, et al. "Relationship Between Corneal Deformation Amplitude and Optic Nerve Head Structure in Primary Open-angle Glaucoma." Medicine, vol. 98, no. 38, 2019, pp. e17223.
Jung Y, Park HL, Park CK. Relationship between corneal deformation amplitude and optic nerve head structure in primary open-angle glaucoma. Medicine (Baltimore). 2019;98(38):e17223.
Jung, Y., Park, H. L., & Park, C. K. (2019). Relationship between corneal deformation amplitude and optic nerve head structure in primary open-angle glaucoma. Medicine, 98(38), pp. e17223. doi:10.1097/MD.0000000000017223.
Jung Y, Park HL, Park CK. Relationship Between Corneal Deformation Amplitude and Optic Nerve Head Structure in Primary Open-angle Glaucoma. Medicine (Baltimore). 2019;98(38):e17223. PubMed PMID: 31567980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between corneal deformation amplitude and optic nerve head structure in primary open-angle glaucoma. AU - Jung,Younhea, AU - Park,Hae-Young Lopilly, AU - Park,Chan Kee, PY - 2019/10/1/entrez PY - 2019/10/1/pubmed PY - 2019/10/11/medline SP - e17223 EP - e17223 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 38 N2 - The purpose of the study was to investigate the relationship between corneal deformation amplitude (DA), which is the amount of corneal displacement at highest degree of concavity measured by Corvis Scheimpflug Technology (ST), and various optic nerve head parameters in patients with primary open-angle glaucoma (POAG).Fifty-eight POAG patients were included in this observational study. For each patient, DA with Corvis ST, color optic disc photography, and optic nerve head imaging by enhanced depth imaging with a Heidelberg spectralis optical coherence tomography (OCT), Cirrus OCT, and Heidelberg retina tomograph (HRT) were obtained. Pearson correlation was used to analyze the relationship between DA and optic nerve head parameters before and after adjusting for age, intraocular pressure, central corneal thickness, and axial length.Corneal DA was negatively associated with lamina cribrosa (LC) depth (r = -0.390, P = .003) after adjusting for confounders. It showed positive relationship with parapapillary atrophy (PPA) area (r = 0.321, P = .046). In addition, the corneal DA was negatively correlated with cup volume (r = -0.351, P = .017) and mean cup depth (r = -0.409, P = .005) measured by HRT.Corneal DA is related with optic nerve head parameters in patients with POAG. Patients with lower corneal DA showed greater LC depth, greater cup area, deeper cup, and smaller PPA than those with higher corneal DA. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31567980/Relationship_between_corneal_deformation_amplitude_and_optic_nerve_head_structure_in_primary_open-angle_glaucoma L2 - http://dx.doi.org/10.1097/MD.0000000000017223 DB - PRIME DP - Unbound Medicine ER -