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Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013.
Influenza Other Respir Viruses. 2020 01; 14(1):67-71.IO

Abstract

To understand the genetic diversity and patterns of circulation of rhinoviruses (RV) and enteroviruses (EV) in Singapore, we retrospectively screened 2950 nasal swab samples collected from adults presenting to primary care services with signs of febrile illness in Singapore during 2007-2013 using sequencing and phylogenetic methods. Through sequencing and phylogenetic analysis, our results show the year-round circulation of the three rhinovirus species, A, B, and C. A diverse set of RV/EV serotypes were detected in Singapore with a predominance of RV-A in all years, whereas serotypes EV-C A21 and EV-D68 were only sporadically detected. This study highlights the previously unrecognized diversity and burden in the adult population in Singapore.

Authors+Show Affiliations

Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore. Duke Global Health Institute, Duke University, Durham, North Carolina.Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore. Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31568667

Citation

Linster, Martin, et al. "Genetic Diversity of Respiratory Enteroviruses and Rhinoviruses in Febrile Adults, Singapore, 2007-2013." Influenza and Other Respiratory Viruses, vol. 14, no. 1, 2020, pp. 67-71.
Linster M, Donato C, Mah MG, et al. Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013. Influenza Other Respir Viruses. 2020;14(1):67-71.
Linster, M., Donato, C., Mah, M. G., Grau, M. L., Low, J. G., Ooi, E. E., Su, Y. C. F., Smith, G. J. D., & Vijaykrishna, D. (2020). Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013. Influenza and Other Respiratory Viruses, 14(1), 67-71. https://doi.org/10.1111/irv.12662
Linster M, et al. Genetic Diversity of Respiratory Enteroviruses and Rhinoviruses in Febrile Adults, Singapore, 2007-2013. Influenza Other Respir Viruses. 2020;14(1):67-71. PubMed PMID: 31568667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013. AU - Linster,Martin, AU - Donato,Celeste, AU - Mah,Marcus G, AU - Grau,Miguel L, AU - Low,Jenny G, AU - Ooi,Eng Eong, AU - Su,Yvonne C F, AU - Smith,Gavin J D, AU - Vijaykrishna,Dhanasekaran, Y1 - 2019/09/30/ PY - 2019/01/14/received PY - 2019/03/31/revised PY - 2019/05/28/accepted PY - 2019/10/1/pubmed PY - 2020/5/29/medline PY - 2019/10/1/entrez KW - Singapore KW - enterovirus KW - febrile illness KW - phylogenetic analysis KW - rhinovirus KW - serotypes KW - virus diversity SP - 67 EP - 71 JF - Influenza and other respiratory viruses JO - Influenza Other Respir Viruses VL - 14 IS - 1 N2 - To understand the genetic diversity and patterns of circulation of rhinoviruses (RV) and enteroviruses (EV) in Singapore, we retrospectively screened 2950 nasal swab samples collected from adults presenting to primary care services with signs of febrile illness in Singapore during 2007-2013 using sequencing and phylogenetic methods. Through sequencing and phylogenetic analysis, our results show the year-round circulation of the three rhinovirus species, A, B, and C. A diverse set of RV/EV serotypes were detected in Singapore with a predominance of RV-A in all years, whereas serotypes EV-C A21 and EV-D68 were only sporadically detected. This study highlights the previously unrecognized diversity and burden in the adult population in Singapore. SN - 1750-2659 UR - https://www.unboundmedicine.com/medline/citation/31568667/Genetic_diversity_of_respiratory_enteroviruses_and_rhinoviruses_in_febrile_adults_Singapore_2007_2013_ DB - PRIME DP - Unbound Medicine ER -