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What are the respiratory effects of e-cigarettes?
BMJ. 2019 09 30; 366:l5275.BMJ

Abstract

Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. Vaping is now a multibillion dollar industry that appeals to current smokers, former smokers, and young people who have never smoked. E-cigarettes reached the market without either extensive preclinical toxicology testing or long term safety trials that would be required of conventional therapeutics or medical devices. Their effectiveness as a smoking cessation intervention, their impact at a population level, and whether they are less harmful than combustible tobacco products are highly controversial. Here, we review the evidence on the effects of e-cigarettes on respiratory health. Studies show measurable adverse biologic effects on organ and cellular health in humans, in animals, and in vitro. The effects of e-cigarettes have similarities to and important differences from those of cigarettes. Decades of chronic smoking are needed for development of lung diseases such as lung cancer or chronic obstructive pulmonary disease, so the population effects of e-cigarette use may not be apparent until the middle of this century. We conclude that current knowledge of these effects is insufficient to determine whether the respiratory health effects of e-cigarette are less than those of combustible tobacco products.

Authors+Show Affiliations

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.Department of Anesthesiology, Duke University, Durham, NC, USA. Yale Center for the Study of Tobacco Products and Addiction, Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.Department of Preventive Medicine, University of Southern California, CA, USA.Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA robert_tarran@med.unc.edu. Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

31570493

Citation

Gotts, Jeffrey E., et al. "What Are the Respiratory Effects of E-cigarettes?" BMJ (Clinical Research Ed.), vol. 366, 2019, p. l5275.
Gotts JE, Jordt SE, McConnell R, et al. What are the respiratory effects of e-cigarettes? BMJ. 2019;366:l5275.
Gotts, J. E., Jordt, S. E., McConnell, R., & Tarran, R. (2019). What are the respiratory effects of e-cigarettes? BMJ (Clinical Research Ed.), 366, l5275. https://doi.org/10.1136/bmj.l5275
Gotts JE, et al. What Are the Respiratory Effects of E-cigarettes. BMJ. 2019 09 30;366:l5275. PubMed PMID: 31570493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What are the respiratory effects of e-cigarettes? AU - Gotts,Jeffrey E, AU - Jordt,Sven-Eric, AU - McConnell,Rob, AU - Tarran,Robert, Y1 - 2019/09/30/ PY - 2019/10/2/entrez PY - 2019/10/2/pubmed PY - 2019/10/8/medline SP - l5275 EP - l5275 JF - BMJ (Clinical research ed.) JO - BMJ VL - 366 N2 - Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. Vaping is now a multibillion dollar industry that appeals to current smokers, former smokers, and young people who have never smoked. E-cigarettes reached the market without either extensive preclinical toxicology testing or long term safety trials that would be required of conventional therapeutics or medical devices. Their effectiveness as a smoking cessation intervention, their impact at a population level, and whether they are less harmful than combustible tobacco products are highly controversial. Here, we review the evidence on the effects of e-cigarettes on respiratory health. Studies show measurable adverse biologic effects on organ and cellular health in humans, in animals, and in vitro. The effects of e-cigarettes have similarities to and important differences from those of cigarettes. Decades of chronic smoking are needed for development of lung diseases such as lung cancer or chronic obstructive pulmonary disease, so the population effects of e-cigarette use may not be apparent until the middle of this century. We conclude that current knowledge of these effects is insufficient to determine whether the respiratory health effects of e-cigarette are less than those of combustible tobacco products. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/31570493/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=31570493 DB - PRIME DP - Unbound Medicine ER -