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Advances in phototherapy for psoriasis and atopic dermatitis.
Expert Rev Clin Immunol. 2019 11; 15(11):1205-1214.ER

Abstract

Introduction: Phototherapy has long been used for the treatment of inflammatory skin diseases, such as psoriasis and atopic dermatitis. The most frequent treatment approach utilizes ultraviolet (UV) light, however, recently, different lasers and low-level light therapies (LLLT) emitting wavelengths in the spectrum of the visible light have also been tried for the treatment of inflammatory skin diseases with variable success.Areas covered: This review provides an update on the different forms of phototherapy used for the treatment of psoriasis and atopic dermatitis. The proposed mechanism of action of the different phototherapeutical approaches are covered, including the immunosuppressive effect of UV light, the anti-inflammatory effect of vascular lasers and the LLLT induced photobiomodulation. The clinical efficacy of the different treatment options is also discussed.Expert opinion: Based on the efficacy and safety, NB-UVB represents the gold standard for treating psoriasis and atopic dermatitis. The UVB excimer laser and excimer lamp might be the best option for clearing localized therapy-resistant lesions. Home UV phototherapy systems might promote treatment adherence and better compliance of the patients. Vascular lasers, IPLs and LLLT, however, can not currently be recommended for the treatment of inflammatory skin diseases because of the lack of well-controlled studies.

Authors+Show Affiliations

Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary. MTA-SZTE Dermatological Research Group, University of Szeged, Szeged, Hungary. HCEMM-USZ Skin Research Group, Szeged, Hungary.Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.Department of Gynaecology, National Insitute of Oncology, Budapest, Hungary.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Video-Audio Media

Language

eng

PubMed ID

31575297

Citation

Kemény, Lajos, et al. "Advances in Phototherapy for Psoriasis and Atopic Dermatitis." Expert Review of Clinical Immunology, vol. 15, no. 11, 2019, pp. 1205-1214.
Kemény L, Varga E, Novak Z. Advances in phototherapy for psoriasis and atopic dermatitis. Expert Rev Clin Immunol. 2019;15(11):1205-1214.
Kemény, L., Varga, E., & Novak, Z. (2019). Advances in phototherapy for psoriasis and atopic dermatitis. Expert Review of Clinical Immunology, 15(11), 1205-1214. https://doi.org/10.1080/1744666X.2020.1672537
Kemény L, Varga E, Novak Z. Advances in Phototherapy for Psoriasis and Atopic Dermatitis. Expert Rev Clin Immunol. 2019;15(11):1205-1214. PubMed PMID: 31575297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in phototherapy for psoriasis and atopic dermatitis. AU - Kemény,Lajos, AU - Varga,Emese, AU - Novak,Zoltan, Y1 - 2019/10/01/ PY - 2019/10/3/pubmed PY - 2020/7/9/medline PY - 2019/10/3/entrez KW - Phototherapy KW - apoptosis KW - atopic dermatitis KW - cytokines KW - immunosuppression KW - laser KW - psoriasis KW - ultraviolet SP - 1205 EP - 1214 JF - Expert review of clinical immunology JO - Expert Rev Clin Immunol VL - 15 IS - 11 N2 - Introduction: Phototherapy has long been used for the treatment of inflammatory skin diseases, such as psoriasis and atopic dermatitis. The most frequent treatment approach utilizes ultraviolet (UV) light, however, recently, different lasers and low-level light therapies (LLLT) emitting wavelengths in the spectrum of the visible light have also been tried for the treatment of inflammatory skin diseases with variable success.Areas covered: This review provides an update on the different forms of phototherapy used for the treatment of psoriasis and atopic dermatitis. The proposed mechanism of action of the different phototherapeutical approaches are covered, including the immunosuppressive effect of UV light, the anti-inflammatory effect of vascular lasers and the LLLT induced photobiomodulation. The clinical efficacy of the different treatment options is also discussed.Expert opinion: Based on the efficacy and safety, NB-UVB represents the gold standard for treating psoriasis and atopic dermatitis. The UVB excimer laser and excimer lamp might be the best option for clearing localized therapy-resistant lesions. Home UV phototherapy systems might promote treatment adherence and better compliance of the patients. Vascular lasers, IPLs and LLLT, however, can not currently be recommended for the treatment of inflammatory skin diseases because of the lack of well-controlled studies. SN - 1744-8409 UR - https://www.unboundmedicine.com/medline/citation/31575297/Advances_in_phototherapy_for_psoriasis_and_atopic_dermatitis_ L2 - http://www.tandfonline.com/doi/full/10.1080/1744666X.2020.1672537 DB - PRIME DP - Unbound Medicine ER -
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