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Laparoscopic Ovarian Drilling Reduces Testosterone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio and Improves Clinical Outcome in Women with Polycystic Ovary Syndrome.
J Hum Reprod Sci. 2019 Jul-Sep; 12(3):224-228.JH

Abstract

Background

Laparoscopic ovarian drilling (LOD) is one of the common modes of treatment for women with polycystic ovary syndrome (PCOS) who are resistant to clomiphene citrate. The data related to the effect of LOD on sex hormones are limited.

Aim

The objective of the study was to investigate the effect of LOD on hormonal parameters and clinical outcomes in women with PCOS.

Settings and Design

This study was conducted in a tertiary care hospital.

Materials and Methods

Fifty PCOS patients who were admitted for LOD were enrolled in the study. Serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels were estimated in all the patients before and after LOD.

Statistical Analysis

Paired t-test was used to assess the differences in hormonal parameters before and after LOD.

Results

LOD reduces testosterone (P < 0.001), LH (P < 0.001), and LH/FSH ratio (P < 0.001), increases FSH (P < 0.001) levels, and improves the rate of ovulation (38/50) and clinical pregnancy (21/50) in PCOS. When subgroup analysis was done, LOD significantly reduced testosterone and LH/FSH ratio in ovulatory and conceived groups. Furthermore, the menstrual cycle became regular, and hirsutism and acne were reduced after LOD in women with PCOS.

Conclusions

LOD reduces testosterone and LH/FSH ratio and improves clinical outcome in PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31576080

Citation

Sinha, Priyanka, et al. "Laparoscopic Ovarian Drilling Reduces Testosterone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio and Improves Clinical Outcome in Women With Polycystic Ovary Syndrome." Journal of Human Reproductive Sciences, vol. 12, no. 3, 2019, pp. 224-228.
Sinha P, Chitra T, Papa D, et al. Laparoscopic Ovarian Drilling Reduces Testosterone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio and Improves Clinical Outcome in Women with Polycystic Ovary Syndrome. J Hum Reprod Sci. 2019;12(3):224-228.
Sinha, P., Chitra, T., Papa, D., & Nandeesha, H. (2019). Laparoscopic Ovarian Drilling Reduces Testosterone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio and Improves Clinical Outcome in Women with Polycystic Ovary Syndrome. Journal of Human Reproductive Sciences, 12(3), 224-228. https://doi.org/10.4103/jhrs.JHRS_161_18
Sinha P, et al. Laparoscopic Ovarian Drilling Reduces Testosterone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio and Improves Clinical Outcome in Women With Polycystic Ovary Syndrome. J Hum Reprod Sci. 2019 Jul-Sep;12(3):224-228. PubMed PMID: 31576080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laparoscopic Ovarian Drilling Reduces Testosterone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio and Improves Clinical Outcome in Women with Polycystic Ovary Syndrome. AU - Sinha,Priyanka, AU - Chitra,Thyagaraju, AU - Papa,Dasari, AU - Nandeesha,Hanumanthappa, PY - 2019/10/3/entrez PY - 2019/10/3/pubmed PY - 2019/10/3/medline KW - Follicle-stimulating hormone KW - laparoscopic ovarian drilling KW - luteinizing hormone KW - polycystic ovary syndrome KW - testosterone SP - 224 EP - 228 JF - Journal of human reproductive sciences JO - J Hum Reprod Sci VL - 12 IS - 3 N2 - Background: Laparoscopic ovarian drilling (LOD) is one of the common modes of treatment for women with polycystic ovary syndrome (PCOS) who are resistant to clomiphene citrate. The data related to the effect of LOD on sex hormones are limited. Aim: The objective of the study was to investigate the effect of LOD on hormonal parameters and clinical outcomes in women with PCOS. Settings and Design: This study was conducted in a tertiary care hospital. Materials and Methods: Fifty PCOS patients who were admitted for LOD were enrolled in the study. Serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels were estimated in all the patients before and after LOD. Statistical Analysis: Paired t-test was used to assess the differences in hormonal parameters before and after LOD. Results: LOD reduces testosterone (P < 0.001), LH (P < 0.001), and LH/FSH ratio (P < 0.001), increases FSH (P < 0.001) levels, and improves the rate of ovulation (38/50) and clinical pregnancy (21/50) in PCOS. When subgroup analysis was done, LOD significantly reduced testosterone and LH/FSH ratio in ovulatory and conceived groups. Furthermore, the menstrual cycle became regular, and hirsutism and acne were reduced after LOD in women with PCOS. Conclusions: LOD reduces testosterone and LH/FSH ratio and improves clinical outcome in PCOS. SN - 0974-1208 UR - https://www.unboundmedicine.com/medline/citation/31576080/Laparoscopic_Ovarian_Drilling_Reduces_Testosterone_and_Luteinizing_Hormone/Follicle-Stimulating_Hormone_Ratio_and_Improves_Clinical_Outcome_in_Women_with_Polycystic_Ovary_Syndrome L2 - http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2019;volume=12;issue=3;spage=224;epage=228;aulast=Sinha DB - PRIME DP - Unbound Medicine ER -
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