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Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations.
Nutrients. 2019 Oct 02; 11(10)N

Abstract

The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.

Authors+Show Affiliations

Institute of Food Science and Human Nutrition, Leibniz University Hannover, 30177 Hannover, Germany. greupner@nutrition.uni-hannover.de.Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, 42119 Wuppertal, Germany. elisabeth.koch@schebb-web.de.Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, 42119 Wuppertal, Germany.Institute of Food Science and Human Nutrition, Leibniz University Hannover, 30177 Hannover, Germany. hahn@nutrition.uni-hannover.de.Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, 42119 Wuppertal, Germany. schebb@uni-wuppertal.de.Institute of Food Science and Human Nutrition, Leibniz University Hannover, 30177 Hannover, Germany. schuchardt@nutrition.uni-hannover.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31581725

Citation

Greupner, Theresa, et al. "Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations." Nutrients, vol. 11, no. 10, 2019.
Greupner T, Koch E, Kutzner L, et al. Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations. Nutrients. 2019;11(10).
Greupner, T., Koch, E., Kutzner, L., Hahn, A., Schebb, N. H., & Schuchardt, J. P. (2019). Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations. Nutrients, 11(10). https://doi.org/10.3390/nu11102346
Greupner T, et al. Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations. Nutrients. 2019 Oct 2;11(10) PubMed PMID: 31581725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations. AU - Greupner,Theresa, AU - Koch,Elisabeth, AU - Kutzner,Laura, AU - Hahn,Andreas, AU - Schebb,Nils Helge, AU - Schuchardt,Jan Philipp, Y1 - 2019/10/02/ PY - 2019/09/12/received PY - 2019/09/26/revised PY - 2019/09/28/accepted PY - 2019/10/5/entrez PY - 2019/10/5/pubmed PY - 2020/3/4/medline KW - conversion KW - polyunsaturated fatty acid metabolism KW - stearidonic acid JF - Nutrients JO - Nutrients VL - 11 IS - 10 N2 - The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)-which is naturally contained in echium oil (EO)-may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31581725/Single_Dose_SDA_Rich_Echium_Oil_Increases_Plasma_EPA_DPAn3_and_DHA_Concentrations_ L2 - https://www.mdpi.com/resolver?pii=nu11102346 DB - PRIME DP - Unbound Medicine ER -