Tags

Type your tag names separated by a space and hit enter

MOG-Ab prevalence in optic neuritis and clinical predictive factors for diagnosis.

Abstract

OBJECTIVE

What is the proportion of antibodies to myelin oligodendrocyte glycoprotein (MOG-Ab) in optic neuritis (ON) in adults and what would be the ON presentation for which MOG-Ab should be tested?

METHODS

Multicentric prospective study conducted during 1 year on all patients diagnosed with acute ON in all ophthalmological units in hospitals in a region in western France.

RESULTS

Sixty-five patients were included. MOG-Ab prevalence was 14% (9/65) during an acute ON and 13% (7/55) after exclusion of patients already diagnosed with multiple sclerosis (MS) (8) or MOG+ON (2). Compared with MS and clinically isolated syndrome, MOG+ON had no female preponderance (67% of men in case of MOG+ON and 22% of men in case of MS and clinically isolated syndrome, p<0.05) were more often bilateral (44% vs 3%, p<0.005) and associated with optic disc swelling (ODS) (78% vs 14%, p<0.001). To predict MOG+ON, the positive predictive values (PPVs) of male sex, ODS and bilateral involvement were 29% (95% CI 9% to 48%), 41% (95% CI 18% to 65%) and 40% (95% CI 10% to 70%), respectively, while the negative predictive values (NPV) were 93% (95% CI 86% to 100%), 96% (95% CI 90% to 100%) and 91% (95% CI 83% to 99%), respectively. The combined factor 'ODS or bilateral or recurrent ON' was the best compromise between PPV (31% (95% CI 14% to 48%)) and NPV (100% (95% CI 100% to 100%)).

CONCLUSION

Among ON episodes, MOG-Ab were found in 14% of cases. MOG+ON occurred without female preponderance and was significantly associated with ODS and/or bilateral ON. Testing MOG-Ab only in patients presenting with ODS or bilateral or recurrent ON would limit MOG-Ab tests to fewer than half of all patients without the risk of missing any MOG+ON cases.

Authors+Show Affiliations

Ophtalmologie, Centre Hospitalier Universitaire de Nantes, Nantes, France jeanbaptiste.ducloyer@chu-nantes.fr.Ophtalmologie, Centre Hospitalier Universitaire d'Angers, Angers, France.Ophtalmologie, Centre Hospitalier de Mans, Le Mans, France.Neurologie, Centre Hospitalier de Mans, Le Mans, France.Ophtalmologie, Centre Hospitalier Universitaire d'Angers, Angers, France.Ophtalmologie, Centre Hospitalier Départemental la Roche-sur-Yon Luçon Montaigu, La Roche-sur-Yon, France.Ophtalmologie, Centre Hospitalier de Saint Nazaire, Saint Nazaire, France.Ophtalmologie, Centre Hospitalier de Cholet, Cholet, France.Ophtalmologie, Centre Hospitalier de Laval, Laval, France.Ophtalmologie, Centre Hospitalier de Challans, Challans, France.Neurologie, Centre Hospitalier Universitaire de Lyon, Lyon, France.Neuroradiologie diagnostique et interventionnelle, Centre Hospitalier Universitaire de Nantes, Nantes, France.Radiologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.Ophtalmologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.Ophtalmologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.Neurologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.Ophtalmologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31582363

Citation

Ducloyer, Jean-Baptiste, et al. "MOG-Ab Prevalence in Optic Neuritis and Clinical Predictive Factors for Diagnosis." The British Journal of Ophthalmology, 2019.
Ducloyer JB, Caignard A, Aidaoui R, et al. MOG-Ab prevalence in optic neuritis and clinical predictive factors for diagnosis. Br J Ophthalmol. 2019.
Ducloyer, J. B., Caignard, A., Aidaoui, R., Ollivier, Y., Plubeau, G., Santos-Moskalyk, S., ... Lebranchu, P. (2019). MOG-Ab prevalence in optic neuritis and clinical predictive factors for diagnosis. The British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2019-314845.
Ducloyer JB, et al. MOG-Ab Prevalence in Optic Neuritis and Clinical Predictive Factors for Diagnosis. Br J Ophthalmol. 2019 Oct 3; PubMed PMID: 31582363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MOG-Ab prevalence in optic neuritis and clinical predictive factors for diagnosis. AU - Ducloyer,Jean-Baptiste, AU - Caignard,Angelique, AU - Aidaoui,Ramzi, AU - Ollivier,Yolaine, AU - Plubeau,Guillaume, AU - Santos-Moskalyk,Sonia, AU - Porphyre,Lindsay, AU - Le Jeune,Caroline, AU - Bihl,Lionel, AU - Alamine,Samy, AU - Marignier,Romain, AU - Bourcier,Romain, AU - Ducloyer,Mathilde, AU - Weber,Michel, AU - Le Meur,Guylène, AU - Wiertlewski,Sandrine, AU - Lebranchu,Pierre, Y1 - 2019/10/03/ PY - 2019/07/02/received PY - 2019/09/03/revised PY - 2019/09/06/accepted PY - 2019/10/5/entrez KW - Aquaporin-4 KW - Multiple sclerosis KW - Myelin oligodendrocyte glycoprotein KW - Neuromyelitis optica KW - Neuromyelitis optica spectrum disorders KW - Optic neuritis KW - Prevalence JF - The British journal of ophthalmology JO - Br J Ophthalmol N2 - OBJECTIVE: What is the proportion of antibodies to myelin oligodendrocyte glycoprotein (MOG-Ab) in optic neuritis (ON) in adults and what would be the ON presentation for which MOG-Ab should be tested? METHODS: Multicentric prospective study conducted during 1 year on all patients diagnosed with acute ON in all ophthalmological units in hospitals in a region in western France. RESULTS: Sixty-five patients were included. MOG-Ab prevalence was 14% (9/65) during an acute ON and 13% (7/55) after exclusion of patients already diagnosed with multiple sclerosis (MS) (8) or MOG+ON (2). Compared with MS and clinically isolated syndrome, MOG+ON had no female preponderance (67% of men in case of MOG+ON and 22% of men in case of MS and clinically isolated syndrome, p<0.05) were more often bilateral (44% vs 3%, p<0.005) and associated with optic disc swelling (ODS) (78% vs 14%, p<0.001). To predict MOG+ON, the positive predictive values (PPVs) of male sex, ODS and bilateral involvement were 29% (95% CI 9% to 48%), 41% (95% CI 18% to 65%) and 40% (95% CI 10% to 70%), respectively, while the negative predictive values (NPV) were 93% (95% CI 86% to 100%), 96% (95% CI 90% to 100%) and 91% (95% CI 83% to 99%), respectively. The combined factor 'ODS or bilateral or recurrent ON' was the best compromise between PPV (31% (95% CI 14% to 48%)) and NPV (100% (95% CI 100% to 100%)). CONCLUSION: Among ON episodes, MOG-Ab were found in 14% of cases. MOG+ON occurred without female preponderance and was significantly associated with ODS and/or bilateral ON. Testing MOG-Ab only in patients presenting with ODS or bilateral or recurrent ON would limit MOG-Ab tests to fewer than half of all patients without the risk of missing any MOG+ON cases. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/31582363/MOG-Ab_prevalence_in_optic_neuritis_and_clinical_predictive_factors_for_diagnosis L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=31582363 DB - PRIME DP - Unbound Medicine ER -