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The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis.
J Diabetes Res. 2019; 2019:3705264.JD

Abstract

Background

The association between Helicobacter pylori infection and glycated hemoglobin A has been confirmed in many studies, but these conclusions are still contradictory and controversial. Therefore, we conducted a meta-analysis to resolve the problem of inconsistent results in diabetes.

Methods

A comprehensive search was conducted on related researches published in PubMed, Embase, and China Academic Journal Full-text Database (CNKI) from the inception of each database to April 2019. Fixed or random effects model was used to pool the weighted mean difference with 95% confidence interval from individual studies. Subgroup and sensitivity analyses were also performed. Publication bias was estimated by funnel plot, Egger's test, and fail-safe numbers.

Results

35 studies with 4,401 participants with diabetes were included in the meta-analysis. Glycated hemoglobin A levels were elevated in patients with Helicobacter pylori infection compared with patients without Helicobacter pylori infection (WMD = 0.50, 95% CI: 0.28-0.72, p < 0.001). In subgroup analysis by the subtype of diabetes, there was a correlation between Helicobacter pylori infection and elevated glycated hemoglobin A in type 1 diabetes (I 2 = 74%, p < 0.001, WMD = 0.46, 95% CI: 0.12-0.80), and in type 2 diabetes (I 2 = 90%, p < 0.001, WMD = 0.59, 95% CI: 0.28-0.90, p < 0.001). In subgroup analysis by the study design, there was a correlation in cross-sectional study (I 2 = 89%, p < 0.001, WMD = 0.42, 95% CI: 0.16-0.69, p ≤ 0.003) and in case-control study (I 2 = 83%, p < 0.001, WMD = 0.39, 95% CI: 0.14-0.64, p ≤ 0.003). By different methods for detecting Helicobacter pylori, there was a correlation in the biopsy group (I 2 = 83%, p < 0.001, WMD = 0.6, 95% CI: 0.11-1.09, p ≤ 0.03) and in other groups of test methods (I 2 = 87%, p < 0.001, WMD = 0.37, 95% CI: 0.17-0.56, p < 0.001). Sensitivity analysis showed that our results were reliable, and no evidence of substantial publication bias was detected.

Conclusion

The meta-analysis might indicate a correlation between Helicobacter pylori infection and glycated hemoglobin A levels in diabetes.

Authors+Show Affiliations

Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050017, China.Graduate School of Hebei Medical University, Shijiazhuang 050017, China.Graduate School of Hebei Medical University, Shijiazhuang 050017, China.Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050017, China. Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital Shijiazhuang, Hebei 050051, China. Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

31583248

Citation

Chen, Jinhu, et al. "The Association Between Helicobacter Pylori Infection and Glycated Hemoglobin a in Diabetes: a Meta-Analysis." Journal of Diabetes Research, vol. 2019, 2019, p. 3705264.
Chen J, Xing Y, Zhao L, et al. The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis. J Diabetes Res. 2019;2019:3705264.
Chen, J., Xing, Y., Zhao, L., & Ma, H. (2019). The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis. Journal of Diabetes Research, 2019, 3705264. https://doi.org/10.1155/2019/3705264
Chen J, et al. The Association Between Helicobacter Pylori Infection and Glycated Hemoglobin a in Diabetes: a Meta-Analysis. J Diabetes Res. 2019;2019:3705264. PubMed PMID: 31583248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis. AU - Chen,Jinhu, AU - Xing,Yuling, AU - Zhao,Liying, AU - Ma,Huijuan, Y1 - 2019/09/09/ PY - 2019/05/15/received PY - 2019/08/10/accepted PY - 2019/10/5/entrez PY - 2019/10/5/pubmed PY - 2020/2/28/medline SP - 3705264 EP - 3705264 JF - Journal of diabetes research JO - J Diabetes Res VL - 2019 N2 - Background: The association between Helicobacter pylori infection and glycated hemoglobin A has been confirmed in many studies, but these conclusions are still contradictory and controversial. Therefore, we conducted a meta-analysis to resolve the problem of inconsistent results in diabetes. Methods: A comprehensive search was conducted on related researches published in PubMed, Embase, and China Academic Journal Full-text Database (CNKI) from the inception of each database to April 2019. Fixed or random effects model was used to pool the weighted mean difference with 95% confidence interval from individual studies. Subgroup and sensitivity analyses were also performed. Publication bias was estimated by funnel plot, Egger's test, and fail-safe numbers. Results: 35 studies with 4,401 participants with diabetes were included in the meta-analysis. Glycated hemoglobin A levels were elevated in patients with Helicobacter pylori infection compared with patients without Helicobacter pylori infection (WMD = 0.50, 95% CI: 0.28-0.72, p < 0.001). In subgroup analysis by the subtype of diabetes, there was a correlation between Helicobacter pylori infection and elevated glycated hemoglobin A in type 1 diabetes (I 2 = 74%, p < 0.001, WMD = 0.46, 95% CI: 0.12-0.80), and in type 2 diabetes (I 2 = 90%, p < 0.001, WMD = 0.59, 95% CI: 0.28-0.90, p < 0.001). In subgroup analysis by the study design, there was a correlation in cross-sectional study (I 2 = 89%, p < 0.001, WMD = 0.42, 95% CI: 0.16-0.69, p ≤ 0.003) and in case-control study (I 2 = 83%, p < 0.001, WMD = 0.39, 95% CI: 0.14-0.64, p ≤ 0.003). By different methods for detecting Helicobacter pylori, there was a correlation in the biopsy group (I 2 = 83%, p < 0.001, WMD = 0.6, 95% CI: 0.11-1.09, p ≤ 0.03) and in other groups of test methods (I 2 = 87%, p < 0.001, WMD = 0.37, 95% CI: 0.17-0.56, p < 0.001). Sensitivity analysis showed that our results were reliable, and no evidence of substantial publication bias was detected. Conclusion: The meta-analysis might indicate a correlation between Helicobacter pylori infection and glycated hemoglobin A levels in diabetes. SN - 2314-6753 UR - https://www.unboundmedicine.com/medline/citation/31583248/The_Association_between_Helicobacter_pylori_Infection_and_Glycated_Hemoglobin_A_in_Diabetes:_A_Meta_Analysis_ L2 - https://doi.org/10.1155/2019/3705264 DB - PRIME DP - Unbound Medicine ER -