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Chronic nicotine exposure attenuates the effects of Δ9 -tetrahydrocannabinol on anxiety-related behavior and social interaction in adult male and female rats.
Brain Behav. 2019 11; 9(11):e01375.BB

Abstract

INTRODUCTION

Anxiogenic and anxiolytic effects of cannabinoids are mediated by different mechanisms, including neural signaling via cannabinoid receptors (CBRs) and nicotinic cholinergic receptors (nAChRs). This study examined the effects of prior nicotine (the psychoactive component in tobacco) exposure on behavioral sensitivity to delta-9-tetrahydrocannabinol (THC; the psychoactive component of cannabis) challenge in animals.

METHODS

Male and female adult Sprague-Dawley rats (N = 96) were injected daily with nicotine (1 mg/kg, i.p.) or vehicle for 14 days, followed by a 14-day drug-free period. On test day, rats were injected with THC (0.5, 2.0, or 5.0 mg/kg, i.p.) or vehicle and anxiety-related behavior was assessed in the emergence (EM), elevated plus maze (EPM), and social interaction (SI) tests.

RESULTS

Chronic nicotine pretreatment attenuated some of the anxiogenic effects induced by THC challenge which can be summarized as follows: (a) THC dose-dependently affected locomotor activity, exploratory behavior, and social interaction in the EM, EPM, and SI tests of unconditioned anxiety; (b) these effects of acute THC challenge were greater in females compared with males except for grooming a conspecific; (c) prior nicotine exposure attenuated the effects of acute THC challenge for locomotor activity in the EPM test; and (d) prior nicotine exposure attenuated the effects of THC challenge for direct but not indirect physical interaction in the SI tests.

CONCLUSIONS

The ability of nicotine prior exposure to produce long-lasting changes that alter the effects of acute THC administration suggests that chronic nicotine may induce neuroplastic changes that influence the subsequent response to novel THC exposure.

Authors+Show Affiliations

Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31583843

Citation

Manwell, Laurie A., et al. "Chronic Nicotine Exposure Attenuates the Effects of Δ9 -tetrahydrocannabinol On Anxiety-related Behavior and Social Interaction in Adult Male and Female Rats." Brain and Behavior, vol. 9, no. 11, 2019, pp. e01375.
Manwell LA, Miladinovic T, Raaphorst E, et al. Chronic nicotine exposure attenuates the effects of Δ9 -tetrahydrocannabinol on anxiety-related behavior and social interaction in adult male and female rats. Brain Behav. 2019;9(11):e01375.
Manwell, L. A., Miladinovic, T., Raaphorst, E., Rana, S., Malecki, S., & Mallet, P. E. (2019). Chronic nicotine exposure attenuates the effects of Δ9 -tetrahydrocannabinol on anxiety-related behavior and social interaction in adult male and female rats. Brain and Behavior, 9(11), e01375. https://doi.org/10.1002/brb3.1375
Manwell LA, et al. Chronic Nicotine Exposure Attenuates the Effects of Δ9 -tetrahydrocannabinol On Anxiety-related Behavior and Social Interaction in Adult Male and Female Rats. Brain Behav. 2019;9(11):e01375. PubMed PMID: 31583843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic nicotine exposure attenuates the effects of Δ9 -tetrahydrocannabinol on anxiety-related behavior and social interaction in adult male and female rats. AU - Manwell,Laurie A, AU - Miladinovic,Tanya, AU - Raaphorst,Elana, AU - Rana,Shadna, AU - Malecki,Sarah, AU - Mallet,Paul E, Y1 - 2019/10/03/ PY - 2018/09/28/received PY - 2019/06/19/revised PY - 2019/06/24/accepted PY - 2019/10/5/pubmed PY - 2020/7/2/medline PY - 2019/10/5/entrez KW - anxiety-related behavior KW - cross-sensitization KW - delta-9-tetrahydrocannabinol KW - drug abuse KW - nicotine KW - social interaction SP - e01375 EP - e01375 JF - Brain and behavior JO - Brain Behav VL - 9 IS - 11 N2 - INTRODUCTION: Anxiogenic and anxiolytic effects of cannabinoids are mediated by different mechanisms, including neural signaling via cannabinoid receptors (CBRs) and nicotinic cholinergic receptors (nAChRs). This study examined the effects of prior nicotine (the psychoactive component in tobacco) exposure on behavioral sensitivity to delta-9-tetrahydrocannabinol (THC; the psychoactive component of cannabis) challenge in animals. METHODS: Male and female adult Sprague-Dawley rats (N = 96) were injected daily with nicotine (1 mg/kg, i.p.) or vehicle for 14 days, followed by a 14-day drug-free period. On test day, rats were injected with THC (0.5, 2.0, or 5.0 mg/kg, i.p.) or vehicle and anxiety-related behavior was assessed in the emergence (EM), elevated plus maze (EPM), and social interaction (SI) tests. RESULTS: Chronic nicotine pretreatment attenuated some of the anxiogenic effects induced by THC challenge which can be summarized as follows: (a) THC dose-dependently affected locomotor activity, exploratory behavior, and social interaction in the EM, EPM, and SI tests of unconditioned anxiety; (b) these effects of acute THC challenge were greater in females compared with males except for grooming a conspecific; (c) prior nicotine exposure attenuated the effects of acute THC challenge for locomotor activity in the EPM test; and (d) prior nicotine exposure attenuated the effects of THC challenge for direct but not indirect physical interaction in the SI tests. CONCLUSIONS: The ability of nicotine prior exposure to produce long-lasting changes that alter the effects of acute THC administration suggests that chronic nicotine may induce neuroplastic changes that influence the subsequent response to novel THC exposure. SN - 2162-3279 UR - https://www.unboundmedicine.com/medline/citation/31583843/Chronic_nicotine_exposure_attenuates_the_effects_of_Δ9__tetrahydrocannabinol_on_anxiety_related_behavior_and_social_interaction_in_adult_male_and_female_rats_ L2 - https://doi.org/10.1002/brb3.1375 DB - PRIME DP - Unbound Medicine ER -