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Investigation on the effect of roller compaction on paracetamol.
Pharm Dev Technol. 2020 Jan; 25(1):100-106.PD

Abstract

Roller compaction is a popular dry granulation method that has been associated with loss of tabletability. In this study, the effect of roller compaction on a model brittle elastic material, paracetamol, was examined. Roller compaction of paracetamol was carried out at three roll force to examine the effects of roll force on the tablet compaction properties. Paracetamol granules consisting of small fragmented crystals were created through the process of roller compaction. A compaction simulator was used to produce tablets from a sieved fraction of roller compacted paracetamol and non-roller compacted paracetamol. Despite the higher elastic energy to plastic energy ratio observed with tablets produced from roller compacted granules of higher forces, the table tensile strength obtained was higher with a lower capping coefficient. At the same time, tablet elastic recovery was found to be lower for tablets produced using roller compacted paracetamol granules. Prefragmentation during roller compaction process helped to reduce the energy required for fragmentation during tablet compaction, increasing the energy available for bond formation. Roller compaction of brittle elastic materials may be a viable option for improving tablet tensile strength and reducing tablet capping.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tay JYS
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore.
Han QE
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore.
Liew CV
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore.
Sia Heng PW
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore, Singapore.

MeSH

AcetaminophenDrug CompoundingExcipientsParticle SizeTabletsTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31583937

Citation

Tay, Justin Yong Soon, et al. "Investigation On the Effect of Roller Compaction On Paracetamol." Pharmaceutical Development and Technology, vol. 25, no. 1, 2020, pp. 100-106.
Tay JYS, Han QE, Liew CV, et al. Investigation on the effect of roller compaction on paracetamol. Pharm Dev Technol. 2020;25(1):100-106.
Tay, J. Y. S., Han, Q. E., Liew, C. V., & Sia Heng, P. W. (2020). Investigation on the effect of roller compaction on paracetamol. Pharmaceutical Development and Technology, 25(1), 100-106. https://doi.org/10.1080/10837450.2019.1676783
Tay JYS, et al. Investigation On the Effect of Roller Compaction On Paracetamol. Pharm Dev Technol. 2020;25(1):100-106. PubMed PMID: 31583937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation on the effect of roller compaction on paracetamol. AU - Tay,Justin Yong Soon, AU - Han,Qi En, AU - Liew,Celine Valeria, AU - Sia Heng,Paul Wan, Y1 - 2019/10/24/ PY - 2019/10/5/pubmed PY - 2020/6/5/medline PY - 2019/10/5/entrez KW - Roller compaction KW - deformation properties KW - elastic deformation KW - paracetamol KW - tableting SP - 100 EP - 106 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 25 IS - 1 N2 - Roller compaction is a popular dry granulation method that has been associated with loss of tabletability. In this study, the effect of roller compaction on a model brittle elastic material, paracetamol, was examined. Roller compaction of paracetamol was carried out at three roll force to examine the effects of roll force on the tablet compaction properties. Paracetamol granules consisting of small fragmented crystals were created through the process of roller compaction. A compaction simulator was used to produce tablets from a sieved fraction of roller compacted paracetamol and non-roller compacted paracetamol. Despite the higher elastic energy to plastic energy ratio observed with tablets produced from roller compacted granules of higher forces, the table tensile strength obtained was higher with a lower capping coefficient. At the same time, tablet elastic recovery was found to be lower for tablets produced using roller compacted paracetamol granules. Prefragmentation during roller compaction process helped to reduce the energy required for fragmentation during tablet compaction, increasing the energy available for bond formation. Roller compaction of brittle elastic materials may be a viable option for improving tablet tensile strength and reducing tablet capping. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/31583937/Investigation_on_the_effect_of_roller_compaction_on_paracetamol_ DB - PRIME DP - Unbound Medicine ER -