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A novel method to trigger the reconsolidation of fear memory.
Behav Res Ther. 2019 11; 122:103461.BR

Abstract

The procedure of memory reconsolidation provides an opportunity to improve some mental disorders caused by maladaptive memories, such as Posttraumatic Stress Disorder. Prediction error was considered a necessary condition for triggering memory reconsolidation. However, it is difficult to create a satisfying prediction error to successfully open memory reconsolidation in a clinical context. The purpose of this study was to explore a more practicable method to trigger memory reconsolidation. We used a successive 4-day fear-potentiated startle paradigm to compare the effect of uncertainty with prediction error during retrieval on preventing the return of fear. Bayes factor, combined with p value and effect size, was used as the main indicator of statistical inference. The results indicated that spontaneous recovery and reinstatement of fear were not observed in the uncertainty group, whereas return of fear was observed for the prediction error group. However, the direct comparison between the two groups did not yield statistically significant results, potentially reflecting a lack of statistical power. Nonetheless, these results suggest that uncertainty retrieval could be a better means to trigger memory reconsolidation than prediction error, making uncertainty a worthwhile factor to consider in future research on memory reconsolidation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yang Y
School of Psychology, South China Normal University, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.
Jie J
School of Psychology, South China Normal University, Guangzhou, China; Center for Mental Health Education, Hainan University, Haikou, China.
Li J
School of Psychology, South China Normal University, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.
Chen W
School of Psychology, South China Normal University, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China.
Zheng X
School of Psychology, South China Normal University, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China. Electronic address: zhengxf@scnu.edu.cn.

MeSH

AdolescentAdultConditioning, ClassicalExtinction, PsychologicalFearFemaleHumansMaleMemory ConsolidationReflex, StartleYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31585344

Citation

Yang, Yong, et al. "A Novel Method to Trigger the Reconsolidation of Fear Memory." Behaviour Research and Therapy, vol. 122, 2019, p. 103461.
Yang Y, Jie J, Li J, et al. A novel method to trigger the reconsolidation of fear memory. Behav Res Ther. 2019;122:103461.
Yang, Y., Jie, J., Li, J., Chen, W., & Zheng, X. (2019). A novel method to trigger the reconsolidation of fear memory. Behaviour Research and Therapy, 122, 103461. https://doi.org/10.1016/j.brat.2019.103461
Yang Y, et al. A Novel Method to Trigger the Reconsolidation of Fear Memory. Behav Res Ther. 2019;122:103461. PubMed PMID: 31585344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel method to trigger the reconsolidation of fear memory. AU - Yang,Yong, AU - Jie,Jing, AU - Li,Junjiao, AU - Chen,Wei, AU - Zheng,Xifu, Y1 - 2019/08/21/ PY - 2018/08/25/received PY - 2019/08/04/revised PY - 2019/08/19/accepted PY - 2019/10/5/pubmed PY - 2020/9/2/medline PY - 2019/10/5/entrez KW - Boundary condition KW - Fear memory KW - Memory reconsolidation KW - Prediction error KW - Uncertainty SP - 103461 EP - 103461 JF - Behaviour research and therapy JO - Behav Res Ther VL - 122 N2 - The procedure of memory reconsolidation provides an opportunity to improve some mental disorders caused by maladaptive memories, such as Posttraumatic Stress Disorder. Prediction error was considered a necessary condition for triggering memory reconsolidation. However, it is difficult to create a satisfying prediction error to successfully open memory reconsolidation in a clinical context. The purpose of this study was to explore a more practicable method to trigger memory reconsolidation. We used a successive 4-day fear-potentiated startle paradigm to compare the effect of uncertainty with prediction error during retrieval on preventing the return of fear. Bayes factor, combined with p value and effect size, was used as the main indicator of statistical inference. The results indicated that spontaneous recovery and reinstatement of fear were not observed in the uncertainty group, whereas return of fear was observed for the prediction error group. However, the direct comparison between the two groups did not yield statistically significant results, potentially reflecting a lack of statistical power. Nonetheless, these results suggest that uncertainty retrieval could be a better means to trigger memory reconsolidation than prediction error, making uncertainty a worthwhile factor to consider in future research on memory reconsolidation. SN - 1873-622X UR - https://www.unboundmedicine.com/medline/citation/31585344/A_novel_method_to_trigger_the_reconsolidation_of_fear_memory_ DB - PRIME DP - Unbound Medicine ER -