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Pharmacological activities of dehydroepiandrosterone: A review.
Steroids 2019; 153:108507S

Abstract

Dehydroepiandrosterone (DHEA) is a steroidal hormone secreted by Zonareticularis of the adrenal cortex with a characteristic age related pattern of secretion. These hormones are inactive precursors that are transformed into active sex steroids in peripheral target tissues. These hormones are used for the energy, vitality and the natural support of most bodily functions that involve the endocrine system. DHEA is a 19 carbon steroid hormone, is lipophilic, and can be converted to DHEAs by activity of the enzyme sulphotransferasein the liver and adrenal glands. These are naturally synthesized in our body through cholesterol- pregnenolone pathway and can also be synthesized from various other sources like diosgenin, geniestein, wild yam, soy and cholesterol in laboratory. It serves as an indirect precursor to estrogen and testosterone and other steroid hormones. This hormone progressively declines at the rate of 2% per year. DHEA evidence a large variety of pharmacological activities like antidiabetic, anticancer, anti-allergic, obesity treatment and cardiovascular property. It is beneficial in autoimmune disorders like lupus erythematosus, immune modulation, muscle building and hormonal problems. DHEA is known as an anti-ageing hormone, in osteoporosis and in dementia. It can also be used as a supplement as directed by the physician in various condition.

Authors+Show Affiliations

Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, CG, India.Columbia Institute of Pharmacy, Raipur, CG, India.Laddhad College of Pharmacy, Yelgaon, Buldana, MS, India. Electronic address: hemantdhongade@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31586606

Citation

Sahu, Poonam, et al. "Pharmacological Activities of Dehydroepiandrosterone: a Review." Steroids, vol. 153, 2019, p. 108507.
Sahu P, Gidwani B, Dhongade HJ. Pharmacological activities of dehydroepiandrosterone: A review. Steroids. 2019;153:108507.
Sahu, P., Gidwani, B., & Dhongade, H. J. (2019). Pharmacological activities of dehydroepiandrosterone: A review. Steroids, 153, p. 108507. doi:10.1016/j.steroids.2019.108507.
Sahu P, Gidwani B, Dhongade HJ. Pharmacological Activities of Dehydroepiandrosterone: a Review. Steroids. 2019 Oct 3;153:108507. PubMed PMID: 31586606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological activities of dehydroepiandrosterone: A review. AU - Sahu,Poonam, AU - Gidwani,Bina, AU - Dhongade,H J, Y1 - 2019/10/03/ PY - 2019/05/28/received PY - 2019/09/21/revised PY - 2019/09/30/accepted PY - 2019/10/7/pubmed PY - 2019/10/7/medline PY - 2019/10/7/entrez KW - Anticancer KW - Dehyroepiandrosterone KW - Lupus erythematosus KW - Pharmacological activities KW - Steroids SP - 108507 EP - 108507 JF - Steroids JO - Steroids VL - 153 N2 - Dehydroepiandrosterone (DHEA) is a steroidal hormone secreted by Zonareticularis of the adrenal cortex with a characteristic age related pattern of secretion. These hormones are inactive precursors that are transformed into active sex steroids in peripheral target tissues. These hormones are used for the energy, vitality and the natural support of most bodily functions that involve the endocrine system. DHEA is a 19 carbon steroid hormone, is lipophilic, and can be converted to DHEAs by activity of the enzyme sulphotransferasein the liver and adrenal glands. These are naturally synthesized in our body through cholesterol- pregnenolone pathway and can also be synthesized from various other sources like diosgenin, geniestein, wild yam, soy and cholesterol in laboratory. It serves as an indirect precursor to estrogen and testosterone and other steroid hormones. This hormone progressively declines at the rate of 2% per year. DHEA evidence a large variety of pharmacological activities like antidiabetic, anticancer, anti-allergic, obesity treatment and cardiovascular property. It is beneficial in autoimmune disorders like lupus erythematosus, immune modulation, muscle building and hormonal problems. DHEA is known as an anti-ageing hormone, in osteoporosis and in dementia. It can also be used as a supplement as directed by the physician in various condition. SN - 1878-5867 UR - https://www.unboundmedicine.com/medline/citation/31586606/Pharmacological_Activities_of_Dehydroepiandrosterone:_A_Review L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-128X(19)30197-7 DB - PRIME DP - Unbound Medicine ER -