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Clinical features of vitamin D deficiency in children: A retrospective analysis.
J Steroid Biochem Mol Biol 2019; 196:105491JS

Abstract

Vitamin D is very important for children's health. Previous studies have shown that vitamin D deficiency leads to a series of diseases in adults. However, pediatricians are mostly aware of rickets caused by vitamin D deficiency in children and poorly aware of other symptoms. This study aimed to retrospectively analyze the different clinical features of vitamin D deficiency to enhance identification by pediatricians, thus minimizing misdiagnosis. In this study, we retrospectively analyzed the clinical features of vitamin D deficiency in 268 children aged 0-14 years from June 2016 to May 2018 in the Third Affiliated Hospital of Zhengzhou University. Serum 25-hydroxy vitamin D [25(OH)D] levels were determined using the chemiluminescence method. Of the 268 cases, 101 cases showed movement disorder (37.7%) and 167 nervous system abnormalities (62.3%). Among all cases, 6 were misdiagnosed as febrile seizures (2.23%), 5 as epilepsy (1.86%), 2 as Tourette syndrome (0.74%), and 2 as developmental retardation (0.74%). There were significant differences in patients with clinical characteristics of movement disorder and nervous system abnormalities partly between Pre-and post-vitamin D treatment. This analysis revealed that vitamin D deficiency occurs not only in children but also in adolescents, with diverse clinical features. Therefore, pediatricians should pay more attention to clinical different signs and symptoms, and future studies should be conducted to confirm the mechanisms of these processes.

Authors+Show Affiliations

The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: Xiangmin0812@163.com.The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: liuzongyuan0315@163.com.The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: Jnxialei2007@163.com.The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: kettis198724@163.com.The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: Xufalin72@126.com.The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: Chenhao226@163.com.The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: 3416858001@qq.com.The Third Affiliated Hospital of Zhengzhou University, China. Electronic address: 592452376@qq.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31586638

Citation

Zhang, Xiangmin, et al. "Clinical Features of Vitamin D Deficiency in Children: a Retrospective Analysis." The Journal of Steroid Biochemistry and Molecular Biology, vol. 196, 2019, p. 105491.
Zhang X, Liu Z, Xia L, et al. Clinical features of vitamin D deficiency in children: A retrospective analysis. J Steroid Biochem Mol Biol. 2019;196:105491.
Zhang, X., Liu, Z., Xia, L., Gao, J., Xu, F., Chen, H., ... Wang, W. (2019). Clinical features of vitamin D deficiency in children: A retrospective analysis. The Journal of Steroid Biochemistry and Molecular Biology, 196, p. 105491. doi:10.1016/j.jsbmb.2019.105491.
Zhang X, et al. Clinical Features of Vitamin D Deficiency in Children: a Retrospective Analysis. J Steroid Biochem Mol Biol. 2019 Oct 3;196:105491. PubMed PMID: 31586638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of vitamin D deficiency in children: A retrospective analysis. AU - Zhang,Xiangmin, AU - Liu,Zongyuan, AU - Xia,Lei, AU - Gao,Junjun, AU - Xu,Falin, AU - Chen,Hao, AU - Du,Yanhua, AU - Wang,Weiwei, Y1 - 2019/10/03/ PY - 2019/04/24/received PY - 2019/09/04/revised PY - 2019/10/01/accepted PY - 2019/10/7/pubmed PY - 2019/10/7/medline PY - 2019/10/7/entrez KW - 25(OH)D KW - Clinical features KW - Movement disorders KW - Nervous system abnormalities KW - Vitamin D deficiency SP - 105491 EP - 105491 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 196 N2 - Vitamin D is very important for children's health. Previous studies have shown that vitamin D deficiency leads to a series of diseases in adults. However, pediatricians are mostly aware of rickets caused by vitamin D deficiency in children and poorly aware of other symptoms. This study aimed to retrospectively analyze the different clinical features of vitamin D deficiency to enhance identification by pediatricians, thus minimizing misdiagnosis. In this study, we retrospectively analyzed the clinical features of vitamin D deficiency in 268 children aged 0-14 years from June 2016 to May 2018 in the Third Affiliated Hospital of Zhengzhou University. Serum 25-hydroxy vitamin D [25(OH)D] levels were determined using the chemiluminescence method. Of the 268 cases, 101 cases showed movement disorder (37.7%) and 167 nervous system abnormalities (62.3%). Among all cases, 6 were misdiagnosed as febrile seizures (2.23%), 5 as epilepsy (1.86%), 2 as Tourette syndrome (0.74%), and 2 as developmental retardation (0.74%). There were significant differences in patients with clinical characteristics of movement disorder and nervous system abnormalities partly between Pre-and post-vitamin D treatment. This analysis revealed that vitamin D deficiency occurs not only in children but also in adolescents, with diverse clinical features. Therefore, pediatricians should pay more attention to clinical different signs and symptoms, and future studies should be conducted to confirm the mechanisms of these processes. SN - 1879-1220 UR - https://www.unboundmedicine.com/medline/citation/31586638/Clinical_features_of_vitamin_D_deficiency_in_children:_A_retrospective_analysis L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(19)30231-6 DB - PRIME DP - Unbound Medicine ER -