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Insulin Resistance Among Pregnant Women in Urban Areas of Arusha Region, Tanzania.
Metab Syndr Relat Disord 2019; 17(10):512-517MS

Abstract

Aim:

To establish the prevalence of insulin resistance (IR) and its determinants among selected pregnant women in urban Arusha for taking preventive measures.

Methods:

A cross-sectional study was conducted between March and December 2018 at Ngarenaro and Kaloleni health facilities in Arusha District involving 230 randomly selected pregnant women who were not known to have diabetes before pregnancy. Blood glucose at fasting and 2 hr after consuming 75 grams of glucose dissolved in 300 mL of water was measured using Gluco-Plus™, serum insulin concentrations using ELISA machine (Synergy/HTX™; BioTek), and IR was calculated using the Homeostasis Model of Assessment formula. Body fat was measured using a bioelectric impedance analyzer, mid-upper arm circumference using a regular tape, weight using SECA™, blood pressure using GT-868UF Geratherm™ machine, and height by stadiometer. Maternal characteristics were collected through face to face interviews using a structured questionnaire. Data were analyzed using the Statistical Package for Social Science™ Version 20.

Results:

The prevalence of IR was 21% (n = 49) and significantly associated with increased body fat percentage (adjusted odds ratio [AOR]: 1.68, 95% confidence interval [CI]: 1.01-2.5), family history of Type 2 diabetes mellitus (T2DM; AOR: 2.77, 95% CI: 1.21-6.33), hypertension (AOR: 2.5, 95% CI: 1.12-5.6), edema (AOR: 3.01, 95% CI: 1.31-6.96), and proteinuria (AOR: 3.44, 95% CI: 1.11-10.69).

Conclusions:

IR was higher among pregnant women with increased body fat percentage, family history of T2DM, hypertension, edema, and proteinuria. These findings call for large-scale screening to further explore risk factors to prevent gestational diabetes mellitus.

Authors+Show Affiliations

School of Life Sciences, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania. Department of Food Technology, Nutrition and Consumer Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.School of Life Sciences, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.Department of Food Technology, Nutrition and Consumer Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.College of Nursing, University of Saskatchewan, Saskatoon, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31589553

Citation

Msollo, Safiness Simon, et al. "Insulin Resistance Among Pregnant Women in Urban Areas of Arusha Region, Tanzania." Metabolic Syndrome and Related Disorders, vol. 17, no. 10, 2019, pp. 512-517.
Msollo SS, Martin HD, Mwanri AW, et al. Insulin Resistance Among Pregnant Women in Urban Areas of Arusha Region, Tanzania. Metab Syndr Relat Disord. 2019;17(10):512-517.
Msollo, S. S., Martin, H. D., Mwanri, A. W., & Petrucka, P. (2019). Insulin Resistance Among Pregnant Women in Urban Areas of Arusha Region, Tanzania. Metabolic Syndrome and Related Disorders, 17(10), pp. 512-517. doi:10.1089/met.2019.0077.
Msollo SS, et al. Insulin Resistance Among Pregnant Women in Urban Areas of Arusha Region, Tanzania. Metab Syndr Relat Disord. 2019;17(10):512-517. PubMed PMID: 31589553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin Resistance Among Pregnant Women in Urban Areas of Arusha Region, Tanzania. AU - Msollo,Safiness Simon, AU - Martin,Haikael David, AU - Mwanri,Akwilina Wendelin, AU - Petrucka,Pammla, Y1 - 2019/10/07/ PY - 2019/10/8/pubmed PY - 2019/10/8/medline PY - 2019/10/8/entrez KW - Arusha-Tanzania KW - gestational diabetes KW - insulin resistance SP - 512 EP - 517 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 17 IS - 10 N2 - Aim: To establish the prevalence of insulin resistance (IR) and its determinants among selected pregnant women in urban Arusha for taking preventive measures. Methods: A cross-sectional study was conducted between March and December 2018 at Ngarenaro and Kaloleni health facilities in Arusha District involving 230 randomly selected pregnant women who were not known to have diabetes before pregnancy. Blood glucose at fasting and 2 hr after consuming 75 grams of glucose dissolved in 300 mL of water was measured using Gluco-Plus™, serum insulin concentrations using ELISA machine (Synergy/HTX™; BioTek), and IR was calculated using the Homeostasis Model of Assessment formula. Body fat was measured using a bioelectric impedance analyzer, mid-upper arm circumference using a regular tape, weight using SECA™, blood pressure using GT-868UF Geratherm™ machine, and height by stadiometer. Maternal characteristics were collected through face to face interviews using a structured questionnaire. Data were analyzed using the Statistical Package for Social Science™ Version 20. Results: The prevalence of IR was 21% (n = 49) and significantly associated with increased body fat percentage (adjusted odds ratio [AOR]: 1.68, 95% confidence interval [CI]: 1.01-2.5), family history of Type 2 diabetes mellitus (T2DM; AOR: 2.77, 95% CI: 1.21-6.33), hypertension (AOR: 2.5, 95% CI: 1.12-5.6), edema (AOR: 3.01, 95% CI: 1.31-6.96), and proteinuria (AOR: 3.44, 95% CI: 1.11-10.69). Conclusions: IR was higher among pregnant women with increased body fat percentage, family history of T2DM, hypertension, edema, and proteinuria. These findings call for large-scale screening to further explore risk factors to prevent gestational diabetes mellitus. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/31589553/Insulin_Resistance_Among_Pregnant_Women_in_Urban_Areas_of_Arusha_Region,_Tanzania L2 - https://www.liebertpub.com/doi/full/10.1089/met.2019.0077?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -