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A peridomestic Aedes malayensis population in Singapore can transmit yellow fever virus.
PLoS Negl Trop Dis. 2019 10; 13(10):e0007783.PN

Abstract

The case-fatality rate of yellow fever virus (YFV) is one of the highest among arthropod-borne viruses (arboviruses). Although historically, the Asia-Pacific region has remained free of YFV, the risk of introduction has never been higher due to the increasing influx of people from endemic regions and the recent outbreaks in Africa and South America. Singapore is a global hub for trade and tourism and therefore at high risk for YFV introduction. Effective control of the main domestic mosquito vector Aedes aegypti in Singapore has failed to prevent re-emergence of dengue, chikungunya and Zika viruses in the last two decades, raising suspicions that peridomestic mosquito species untargeted by domestic vector control measures may contribute to arbovirus transmission. Here, we provide empirical evidence that the peridomestic mosquito Aedes malayensis found in Singapore can transmit YFV. Our laboratory mosquito colony recently derived from wild Ae. malayensis in Singapore was experimentally competent for YFV to a similar level as Ae. aegypti controls. In addition, we captured Ae. malayensis females in one human-baited trap during three days of collection, providing preliminary evidence that host-vector contact may occur in field conditions. Finally, we detected Ae. malayensis eggs in traps deployed in high-rise building areas of Singapore. We conclude that Ae. malayensis is a competent vector of YFV and re-emphasize that vector control methods should be extended to target peridomestic vector species.

Authors+Show Affiliations

Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France. Sorbonne Université, Collège doctoral, Paris, France. Medical Entomology and Vector-Borne Disease Unit, Institut Pasteur du Laos, Vientiane, Lao PDR.Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.Program in Emerging Infectious Disease, Duke-NUS Medical School, Singapore.Medical Entomology and Vector-Borne Disease Unit, Institut Pasteur du Laos, Vientiane, Lao PDR.Environmental Health Institute, National Environment Agency, Singapore.Environmental Health Institute, National Environment Agency, Singapore.Arboviruses and Insect Vectors Unit, Institut Pasteur, Paris, France.Program in Emerging Infectious Disease, Duke-NUS Medical School, Singapore. MIVEGEC, IRD, CNRS, Univ. Montpellier, Montpellier, France.Medical Entomology and Vector-Borne Disease Unit, Institut Pasteur du Laos, Vientiane, Lao PDR.Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31589616

Citation

Miot, Elliott F., et al. "A Peridomestic Aedes Malayensis Population in Singapore Can Transmit Yellow Fever Virus." PLoS Neglected Tropical Diseases, vol. 13, no. 10, 2019, pp. e0007783.
Miot EF, Aubry F, Dabo S, et al. A peridomestic Aedes malayensis population in Singapore can transmit yellow fever virus. PLoS Negl Trop Dis. 2019;13(10):e0007783.
Miot, E. F., Aubry, F., Dabo, S., Mendenhall, I. H., Marcombe, S., Tan, C. H., Ng, L. C., Failloux, A. B., Pompon, J., Brey, P. T., & Lambrechts, L. (2019). A peridomestic Aedes malayensis population in Singapore can transmit yellow fever virus. PLoS Neglected Tropical Diseases, 13(10), e0007783. https://doi.org/10.1371/journal.pntd.0007783
Miot EF, et al. A Peridomestic Aedes Malayensis Population in Singapore Can Transmit Yellow Fever Virus. PLoS Negl Trop Dis. 2019;13(10):e0007783. PubMed PMID: 31589616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A peridomestic Aedes malayensis population in Singapore can transmit yellow fever virus. AU - Miot,Elliott F, AU - Aubry,Fabien, AU - Dabo,Stéphanie, AU - Mendenhall,Ian H, AU - Marcombe,Sébastien, AU - Tan,Cheong H, AU - Ng,Lee C, AU - Failloux,Anna-Bella, AU - Pompon,Julien, AU - Brey,Paul T, AU - Lambrechts,Louis, Y1 - 2019/10/07/ PY - 2019/07/10/received PY - 2019/09/15/accepted PY - 2019/10/17/revised PY - 2019/10/8/pubmed PY - 2020/2/6/medline PY - 2019/10/8/entrez SP - e0007783 EP - e0007783 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 13 IS - 10 N2 - The case-fatality rate of yellow fever virus (YFV) is one of the highest among arthropod-borne viruses (arboviruses). Although historically, the Asia-Pacific region has remained free of YFV, the risk of introduction has never been higher due to the increasing influx of people from endemic regions and the recent outbreaks in Africa and South America. Singapore is a global hub for trade and tourism and therefore at high risk for YFV introduction. Effective control of the main domestic mosquito vector Aedes aegypti in Singapore has failed to prevent re-emergence of dengue, chikungunya and Zika viruses in the last two decades, raising suspicions that peridomestic mosquito species untargeted by domestic vector control measures may contribute to arbovirus transmission. Here, we provide empirical evidence that the peridomestic mosquito Aedes malayensis found in Singapore can transmit YFV. Our laboratory mosquito colony recently derived from wild Ae. malayensis in Singapore was experimentally competent for YFV to a similar level as Ae. aegypti controls. In addition, we captured Ae. malayensis females in one human-baited trap during three days of collection, providing preliminary evidence that host-vector contact may occur in field conditions. Finally, we detected Ae. malayensis eggs in traps deployed in high-rise building areas of Singapore. We conclude that Ae. malayensis is a competent vector of YFV and re-emphasize that vector control methods should be extended to target peridomestic vector species. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/31589616/A_peridomestic_Aedes_malayensis_population_in_Singapore_can_transmit_yellow_fever_virus_ L2 - https://dx.plos.org/10.1371/journal.pntd.0007783 DB - PRIME DP - Unbound Medicine ER -