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Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food.

Abstract

Compulsive eating characterizes many binge-related eating disorders, yet its neurobiological basis is poorly understood. The insular cortex subserves visceral-emotional functions, including taste processing, and is implicated in drug craving and relapse. Here, via optoinhibition, we implicate projections from the anterior insular cortex to the nucleus accumbens as modulating highly compulsive-like food self-administration behaviors that result from intermittent access to a palatable, high-sucrose diet. We identified compulsive-like eating behavior in female rats through progressive ratio schedule self-administration and punishment-resistant responding, food reward tolerance and escalation of intake through 24-h energy intake and fixed-ratio operant self-administration sessions, and withdrawal-like irritability through the bottle brush test. We also identified an endocrine profile of heightened GLP-1 and PP but lower ghrelin that differentiated rats with the most compulsive-like eating behavior. Measures of compulsive eating severity also directly correlated to leptin, body weight and adiposity. Collectively, this novel model of compulsive-like eating symptoms demonstrates adaptations in insula-ventral striatal circuitry and metabolic regulatory hormones that warrant further study.

Authors+Show Affiliations

Department of Neuroscience, The Scripps Research Institute, The Scripps Research Institute, 10550N. Torrey Pines Rd., La Jolla, CA, 92037, USA. samspier@scripps.edu.Department of Neuroscience, The Scripps Research Institute, The Scripps Research Institute, 10550N. Torrey Pines Rd., La Jolla, CA, 92037, USA.Department of Neuroscience, The Scripps Research Institute, The Scripps Research Institute, 10550N. Torrey Pines Rd., La Jolla, CA, 92037, USA.Department of Neuroscience, The Scripps Research Institute, The Scripps Research Institute, 10550N. Torrey Pines Rd., La Jolla, CA, 92037, USA.Department of Neuroscience, The Scripps Research Institute, The Scripps Research Institute, 10550N. Torrey Pines Rd., La Jolla, CA, 92037, USA.Department of Neuroscience, The Scripps Research Institute, The Scripps Research Institute, 10550N. Torrey Pines Rd., La Jolla, CA, 92037, USA.Department of Neuroscience, The Scripps Research Institute, The Scripps Research Institute, 10550N. Torrey Pines Rd., La Jolla, CA, 92037, USA. ezorrill@scripps.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31593982

Citation

Spierling, Samantha, et al. "Insula to Ventral Striatal Projections Mediate Compulsive Eating Produced By Intermittent Access to Palatable Food." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2019.
Spierling S, de Guglielmo G, Kirson D, et al. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology. 2019.
Spierling, S., de Guglielmo, G., Kirson, D., Kreisler, A., Roberto, M., George, O., & Zorrilla, E. P. (2019). Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, doi:10.1038/s41386-019-0538-x.
Spierling S, et al. Insula to Ventral Striatal Projections Mediate Compulsive Eating Produced By Intermittent Access to Palatable Food. Neuropsychopharmacology. 2019 Oct 8; PubMed PMID: 31593982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. AU - Spierling,Samantha, AU - de Guglielmo,Giordano, AU - Kirson,Dean, AU - Kreisler,Alison, AU - Roberto,Marisa, AU - George,Olivier, AU - Zorrilla,Eric P, Y1 - 2019/10/08/ PY - 2019/03/04/received PY - 2019/09/29/accepted PY - 2019/09/26/revised PY - 2019/10/9/pubmed PY - 2019/10/9/medline PY - 2019/10/9/entrez JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology N2 - Compulsive eating characterizes many binge-related eating disorders, yet its neurobiological basis is poorly understood. The insular cortex subserves visceral-emotional functions, including taste processing, and is implicated in drug craving and relapse. Here, via optoinhibition, we implicate projections from the anterior insular cortex to the nucleus accumbens as modulating highly compulsive-like food self-administration behaviors that result from intermittent access to a palatable, high-sucrose diet. We identified compulsive-like eating behavior in female rats through progressive ratio schedule self-administration and punishment-resistant responding, food reward tolerance and escalation of intake through 24-h energy intake and fixed-ratio operant self-administration sessions, and withdrawal-like irritability through the bottle brush test. We also identified an endocrine profile of heightened GLP-1 and PP but lower ghrelin that differentiated rats with the most compulsive-like eating behavior. Measures of compulsive eating severity also directly correlated to leptin, body weight and adiposity. Collectively, this novel model of compulsive-like eating symptoms demonstrates adaptations in insula-ventral striatal circuitry and metabolic regulatory hormones that warrant further study. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/31593982/Insula_to_ventral_striatal_projections_mediate_compulsive_eating_produced_by_intermittent_access_to_palatable_food L2 - http://dx.doi.org/10.1038/s41386-019-0538-x DB - PRIME DP - Unbound Medicine ER -