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Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature.
J Clin Exp Dent 2019; 11(8):e721-e731JC

Abstract

Background

Oral neural tumors (ONTs) are rare lesions and represent reactive or neoplastic proliferations of nerve sheath cells. The purpose of the present study is to report the clinical, demographic and histopathologic features of 157 ONTs diagnosed in a single Oral Pathology Department and review the pertinent literature.

Material and Methods

157 cases of ONTs diagnosed during a 44-year period were retrospectively collected and the diagnosis was reconfirmed by studying representative haematoxylin and eosin stained tissue sections. The patients' gender and age, as well as the main clinical features of the lesions, were retrieved from the biopsy submission forms.

Results

The 157 ONTs represented approximately 0.4% of 35,590 biopsies accessioned during the study period. They affected 71 male and 86 female patients with a mean age of 38.4±18.8 years. They mainly appeared as asymptomatic nodules of normal or white colour on the tongue, lip mucosa and hard palate. The most common ONT was granular cell tumour (38.9%) followed by neurofibroma (19.7%), schwannoma (15.9%), traumatic neuroma (15.9%), palisaded encapsulated neuroma (8.3%) and nerve sheath myxoma (1.3%).

Conclusions

This study confirmed the rarity of ONTs. Their clinical characteristics mimic other oral lesions; thus, microscopic examination is the only mean to arrive at a definitive diagnosis. Key words:Oral neural tumors; oral neural neoplasms; neurofibroma; oral neurofibroma; schwannoma; oral schwannoma; neurilemmoma; oral neurilemmoma; granular cell tumor; oral granular cell tumor; traumatic neuroma; oral traumatic neuroma; palisaded encapsulated neuroma; oral palisaded encapsulated neuroma.

Authors+Show Affiliations

DDS, MSc, Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, Greece.DDS, PhD, Associate Professor, Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, Greece.DDS, MSc, PhD, Professor, Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, Greece.MD, DDS, PhD, Professor, Head of Department of Oral Medicine and Pathology, Department of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31598201

Citation

Tamiolakis, Paris, et al. "Oral Neural Tumors: Clinicopathologic Analysis of 157 Cases and Review of the Literature." Journal of Clinical and Experimental Dentistry, vol. 11, no. 8, 2019, pp. e721-e731.
Tamiolakis P, Chrysomali E, Sklavounou-Andrikopoulou A, et al. Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature. J Clin Exp Dent. 2019;11(8):e721-e731.
Tamiolakis, P., Chrysomali, E., Sklavounou-Andrikopoulou, A., & Nikitakis, N. G. (2019). Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature. Journal of Clinical and Experimental Dentistry, 11(8), pp. e721-e731. doi:10.4317/jced.55944.
Tamiolakis P, et al. Oral Neural Tumors: Clinicopathologic Analysis of 157 Cases and Review of the Literature. J Clin Exp Dent. 2019;11(8):e721-e731. PubMed PMID: 31598201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature. AU - Tamiolakis,Paris, AU - Chrysomali,Evanthia, AU - Sklavounou-Andrikopoulou,Alexandra, AU - Nikitakis,Nikolaos G, Y1 - 2019/08/01/ PY - 2019/05/29/received PY - 2019/07/04/accepted PY - 2019/10/11/entrez PY - 2019/10/11/pubmed PY - 2019/10/11/medline SP - e721 EP - e731 JF - Journal of clinical and experimental dentistry JO - J Clin Exp Dent VL - 11 IS - 8 N2 - Background: Oral neural tumors (ONTs) are rare lesions and represent reactive or neoplastic proliferations of nerve sheath cells. The purpose of the present study is to report the clinical, demographic and histopathologic features of 157 ONTs diagnosed in a single Oral Pathology Department and review the pertinent literature. Material and Methods: 157 cases of ONTs diagnosed during a 44-year period were retrospectively collected and the diagnosis was reconfirmed by studying representative haematoxylin and eosin stained tissue sections. The patients' gender and age, as well as the main clinical features of the lesions, were retrieved from the biopsy submission forms. Results: The 157 ONTs represented approximately 0.4% of 35,590 biopsies accessioned during the study period. They affected 71 male and 86 female patients with a mean age of 38.4±18.8 years. They mainly appeared as asymptomatic nodules of normal or white colour on the tongue, lip mucosa and hard palate. The most common ONT was granular cell tumour (38.9%) followed by neurofibroma (19.7%), schwannoma (15.9%), traumatic neuroma (15.9%), palisaded encapsulated neuroma (8.3%) and nerve sheath myxoma (1.3%). Conclusions: This study confirmed the rarity of ONTs. Their clinical characteristics mimic other oral lesions; thus, microscopic examination is the only mean to arrive at a definitive diagnosis. Key words:Oral neural tumors; oral neural neoplasms; neurofibroma; oral neurofibroma; schwannoma; oral schwannoma; neurilemmoma; oral neurilemmoma; granular cell tumor; oral granular cell tumor; traumatic neuroma; oral traumatic neuroma; palisaded encapsulated neuroma; oral palisaded encapsulated neuroma. SN - 1989-5488 UR - https://www.unboundmedicine.com/medline/citation/31598201/Oral_neural_tumors:_Clinicopathologic_analysis_of_157_cases_and_review_of_the_literature L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31598201/ DB - PRIME DP - Unbound Medicine ER -