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Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia.
Cureus 2019; 11(8):e5320C

Abstract

Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials to elucidate the role of naltrexone in human psychogenic drinking behavior.

Authors+Show Affiliations

Psychiatry, Manhattan Psychiatric Center, Manhattan, USA.Psychiatric, Manhattan Psychiatric Center, Manhattan, USA.Psychiatry, University of Texas Rio Grande Valley, Harlingen, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31598428

Citation

Rizvi, Sukaina, et al. "Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia." Cureus, vol. 11, no. 8, 2019, pp. e5320.
Rizvi S, Gold J, Khan AM. Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia. Cureus. 2019;11(8):e5320.
Rizvi, S., Gold, J., & Khan, A. M. (2019). Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia. Cureus, 11(8), pp. e5320. doi:10.7759/cureus.5320.
Rizvi S, Gold J, Khan AM. Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia. Cureus. 2019 Aug 5;11(8):e5320. PubMed PMID: 31598428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Naltrexone in Improving Compulsive Drinking in Psychogenic Polydipsia. AU - Rizvi,Sukaina, AU - Gold,Jeffrey, AU - Khan,Ali M, Y1 - 2019/08/05/ PY - 2019/10/11/entrez PY - 2019/10/11/pubmed PY - 2019/10/11/medline KW - compulsive drinking KW - naltrexone KW - opioid receptor KW - psychogenic polydipsia KW - schizophrenia SP - e5320 EP - e5320 JF - Cureus JO - Cureus VL - 11 IS - 8 N2 - Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials to elucidate the role of naltrexone in human psychogenic drinking behavior. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/31598428/Role_of_Naltrexone_in_Improving_Compulsive_Drinking_in_Psychogenic_Polydipsia L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31598428/ DB - PRIME DP - Unbound Medicine ER -